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Patl1 Gene Detail
Summary
  • Symbol
    Patl1
  • Name
    protein associated with topoisomerase II homolog 1 (yeast)
  • Synonyms
    Pat1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147679
    NCBI Gene: 225929
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:11889763-11922455 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 19, 8.57 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    257 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147679
protein coding gene Chr19:11889728-11922462 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024889
protein coding gene Chr19:9311256-9344989 (+)
A/J MGP_AJ_G0024865
protein coding gene Chr19:8791755-8824250 (+)
AKR/J MGP_AKRJ_G0024838
protein coding gene Chr19:9130383-9162795 (+)
BALB/cJ MGP_BALBcJ_G0024865
protein coding gene Chr19:8798815-8831384 (+)
C3H/HeJ MGP_C3HHeJ_G0024629
protein coding gene Chr19:9022255-9055946 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025313
protein coding gene Chr19:9767585-9814596 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022739
protein coding gene Chr19:9374902-9407795 (+)
CAST/EiJ MGP_CASTEiJ_G0024102
protein coding gene Chr19:8631347-8665276 (+)
CBA/J MGP_CBAJ_G0024604
protein coding gene Chr19:9844779-9883674 (+)
DBA/2J MGP_DBA2J_G0024732
protein coding gene Chr19:8756458-8788745 (+)
FVB/NJ MGP_FVBNJ_G0024697
protein coding gene Chr19:8787200-8819703 (+)
LP/J MGP_LPJ_G0024819
protein coding gene Chr19:9318999-9351842 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024724
protein coding gene Chr19:9754849-9789401 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025361
protein coding gene Chr19:9111012-9145865 (+)
PWK/PhJ MGP_PWKPhJ_G0023847
protein coding gene Chr19:8229400-8261521 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023652
protein coding gene Chr19:8284083-8318477 (+)
WSB/EiJ MGP_WSBEiJ_G0024164
protein coding gene Chr19:8968235-9005638 (+)



Homology
more
  • Human Ortholog
    PATL1, PAT1 homolog 1, processing body mRNA decay factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PATL1, PAT1 homolog 1, processing body mRNA decay factor
  • Synonyms
    hPat1b, Pat1b
  • Links
    NCBI Gene ID: 219988
    neXtProt AC: NX_Q86TB9
    UniProt: Q86TB9

  • Chr Location
    11q12.1; chr11:59636716-59669037 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046139 Ensembl Gene Model | MGI Sequence Detail 32693 C57BL/6J ±  kb
transcript ENSMUST00000061618 Ensembl | MGI Sequence Detail 4216 Not Applicable  
polypeptide ENSMUSP00000060398 Ensembl | MGI Sequence Detail 770 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 5
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory