Yars
Gene Detail

Symbol Name ID

Yars tyrosyl-tRNA synthetase MGI:2147627

Feature Type

protein coding gene

Genetic Map

Chromosome 4

63.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:129189760-129219607 bp, + strand From VEGA annotation of GRCm38   29848 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2730  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine tRNA ligase, archaeal/eukaryotic types
Gene Tree: Yars

Human homologs

Human Homolog		YARS, tyrosyl-tRNA synthetase
NCBI Gene ID		8565
neXtProt AC		NX_P54577
Human Synonyms		CMTDIC, TYRRS, YRS, YTS
Human Chr (Location)		1p35.1; chr1:33240840-33283633 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human YARS

Alleles and phenotypes

All alleles(71) : Targeted(1) Gene trapped(70)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	translation, tRNA aminoacylation for protein translation, ...
Component	cytoplasm, nucleus
Function	aminoacyl-tRNA ligase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (117)    Tissues (108)    Images (20)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	117

cDNA source data(153)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(154) cDNA(153) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000009617 (Evidence)
Ensembl Gene Model	ENSMUSG00000028811 (Evidence)
Entrez Gene	107271 (Evidence)
UniGene	145488
DFCI	TC1573480, TC1605193, TC1772859
NIA Mouse Gene Index	U004860
EC	6.1.1.1
Consensus CDS Project	CCDS18685.1
International Mouse Knockout Project Status	Yars

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009617	VEGA Gene Model | MGI Sequence Detail	29848	C57BL/6J
transcript	OTTMUST00000022122	VEGA | MGI Sequence Detail	2909	Not Applicable
polypeptide	OTTMUSP00000010084	VEGA | MGI Sequence Detail	564	Not Applicable

All sequences(65) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(165 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002305	Aminoacyl-tRNA synthetase, class Ic
InterPro	IPR012340	Nucleic acid-binding, OB-fold
InterPro	IPR016027	Nucleic acid-binding, OB-fold-like
InterPro	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
InterPro	IPR002547	tRNA-binding domain
InterPro	IPR002307	Tyrosine-tRNA ligase
InterPro	IPR023617	Tyrosine-tRNA ligase, archaeal/eukaryotic-type
Protein Ontology	PR:000017523	tyrosyl-tRNA synthetase, cytoplasmic

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)

Other accession IDs

MGI:2140444