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Otub1
Gene Detail
 Symbol
Name
ID
Otub1
OTU domain, ubiquitin aldehyde binding 1
MGI:2147616
Feature Type protein coding gene
Genetic Map
Chromosome 19
5.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:7198202-7206316 bp, - strand
From VEGA annotation of GRCm38

  8115 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9772  Vertebrate Homology Class
1 mouse; 1 rat; 1 dog; 2 zebrafish

Protein SuperFamily: ubiquitin thioesterase Otubain
Gene Tree: Otub1

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(14) Targeted(2)
Incidental mutations (data from APF )
Interactions
Otub1 interacts with 152 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component cytoplasm, nucleus
Function cysteine-type peptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (51)    Tissues (51)    Images (7)
Theiler Stages: 11, 13, 17, 21, 23, 27, 28
Assay TypeResults
RNA in situ 51
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000033932 (Evidence)
Ensembl Gene ModelENSMUSG00000024767 (Evidence)
Entrez Gene107260 (Evidence)
DFCITC1575326
DoTSDT.87068763, DT.94345001
NIA Mouse Gene IndexU038676
EC3.4.19.12
Consensus CDS ProjectCCDS29520.1
International Mouse Knockout Project StatusOtub1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033932 VEGA Gene Model | MGI Sequence Detail 8115 C57BL/6J ±  kb
transcript OTTMUST00000085597 VEGA | MGI Sequence Detail 1713 Not Applicable 
polypeptide OTTMUSP00000046263 VEGA | MGI Sequence Detail 271 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(2 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003323 Ovarian tumour, otubain
InterPro IPR019400 Peptidase C65, otubain
InterPro IPR016615 Ubiquitin thioesterase Otubain
Protein Ontology PR:000012080 ubiquitin thioesterase OTUB1
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:182258 Taher L, et al., Global gene expression analysis of murine limb development. PLoS One. 2011;6(12):e28358
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory