About   Help   FAQ
Otub1
Gene Detail
Symbol

Name
ID
Otub1
OTU domain, ubiquitin aldehyde binding 1
MGI:2147616
Feature Type
protein coding gene
Genetic Map
Chromosome 19
5.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:7198202-7206316 bp, - strand
From VEGA annotation of GRCm38

  8115 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9772  Vertebrate Homology Class
1 mouse; 1 rat; 1 dog; 2 zebrafish

HCOP human homology predictions: OTUB1
Protein SuperFamily: ubiquitin thioesterase Otubain
Gene Tree: Otub1

Human
homologs
OTUB1, OTU deubiquitinase, ubiquitin aldehyde binding 1
Orthology source: HGNC

IDs:
NCBI Gene ID: 55611
neXtProt AC: NX_Q96FW1

Human Synonyms: HSPC263, OTB1, OTU1

Human Chr (Location): 11q13.1; chr11:63985853-63998420 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(14) Targeted(2)
Incidental mutations (data from APF )
Interactions
Otub1 interacts with 151 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process adaptive immune response, cellular response to DNA damage stimulus, ...
Component cytoplasm, nucleus
Function cysteine-type peptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (51)    Tissues (51)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 51
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase otub1 ; ZFIN otub1a, otub1b    NEW 
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000033932 (Evidence)
Ensembl Gene Model ENSMUSG00000024767 (Evidence)
Entrez Gene 107260 (Evidence)
DFCI TC1575326
DoTS DT.87068763, DT.94345001
NIA Mouse Gene Index U038676
EC 3.4.19.12
Consensus CDS Project CCDS29520.1
International Mouse Phenotyping Consortium Status Otub1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033932 VEGA Gene Model | MGI Sequence Detail 8115 C57BL/6J ±  kb
transcript OTTMUST00000085597 VEGA | MGI Sequence Detail 1713 Not Applicable 
polypeptide OTTMUSP00000046263 VEGA | MGI Sequence Detail 271 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(2 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003323 OTU domain
InterPro IPR019400 Peptidase C65, otubain
InterPro IPR030298 Ubiquitin thioesterase OTUB1
InterPro IPR016615 Ubiquitin thioesterase Otubain
Protein Ontology PR:000012080 ubiquitin thioesterase OTUB1
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:182258 Taher L, et al., Global gene expression analysis of murine limb development. PLoS One. 2011;6(12):e28358
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory