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Ffar4
Gene Detail
 Symbol
Name
ID
Ffar4
free fatty acid receptor 4
MGI:2147577
Synonyms Gpr120, Gpr129, O3far1, Pgr4
Feature Type protein coding gene
Genetic Map
Chromosome 19
32.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:38097079-38114263 bp, + strand
From NCBI annotation of GRCm38

  17185 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18769  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: G protein-coupled receptor 120
Gene Tree: Ffar4

Human
homologs
Human Homolog FFAR4, free fatty acid receptor 4
NCBI Gene ID 338557
neXtProt AC  NX_Q5NUL3
Human Synonyms  BMIQ10, GPR120, GPR129, GT01, O3FAR1, PGR4
Human Chr (Location)  10q23.33; chr10:93566665-93590072 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(4) Targeted(9)
Incidental mutations (data from APF )
 
Mice homozygous for a null mutation display diminished preference for and taste nerve response to fatty acids. Mice homozygous for a different knock-out allele exhibit increased susceptibility to diet-induced obesity.
 
Interactions
Ffar4 interacts with 42 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process detection of chemical stimulus involved in sensory perception of taste, G-protein coupled receptor signaling pathway, ...
Component endocytic vesicle, integral component of membrane, ...
Function fatty acid binding, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000054200 (Evidence)
Entrez Gene107221 (Evidence)
UniGene35288
DFCITC1584303
DoTSDT.480882
NIA Mouse Gene IndexU100866
Consensus CDS ProjectCCDS29783.1
International Mouse Knockout Project StatusFfar4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 107221 NCBI Gene Model | MGI Sequence Detail 17185 C57BL/6J ±  kb
transcript NM_181748 RefSeq | MGI Sequence Detail 1393 C57BL/6 
polypeptide Q7TMA4 UniProt | EBI | MGI Sequence Detail 361 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001417 free fatty acid receptor 4
Graphical View of Protein Domain Structure
References (Earliest) J:83410 Vassilatis DK, et al., The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4903-8
(Latest) J:211675 Stone VM, et al., GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans. Diabetologia. 2014 Jun;57(6):1182-91
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory