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Ffar4 Gene Detail
Summary
  • Symbol
    Ffar4
  • Name
    free fatty acid receptor 4
  • Synonyms
    Ffa4, Gpr120, Gpr129, O3far1, Pgr4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147577
    NCBI Gene: 107221
  • Gene Overview
    MyGene.info: FFAR4
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:38097079-38114263 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 32.73 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    137 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147577
protein coding gene Chr19:38097079-38114263 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025087
protein coding gene Chr19:37115084-37134834 (+)
A/J MGP_AJ_G0025063
protein coding gene Chr19:35314909-35332509 (+)
AKR/J MGP_AKRJ_G0025031
protein coding gene Chr19:36516379-36534005 (+)
BALB/cJ MGP_BALBcJ_G0025061
protein coding gene Chr19:35420795-35441120 (+)
C3H/HeJ MGP_C3HHeJ_G0024820
protein coding gene Chr19:36587030-36606523 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025502
protein coding gene Chr19:38181981-38198995 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022921
protein coding gene Chr19:34669815-34688042 (+)
CAST/EiJ MGP_CASTEiJ_G0024287
protein coding gene Chr19:36458150-36475213 (+)
CBA/J MGP_CBAJ_G0024797
protein coding gene Chr19:39961070-39980235 (+)
DBA/2J MGP_DBA2J_G0024929
protein coding gene Chr19:35168174-35186323 (+)
FVB/NJ MGP_FVBNJ_G0024890
protein coding gene Chr19:34977221-34999065 (+)
LP/J MGP_LPJ_G0025015
protein coding gene Chr19:37213696-37232474 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024921
protein coding gene Chr19:39739249-39760934 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025560
protein coding gene Chr19:36615141-36632794 (+)
PWK/PhJ MGP_PWKPhJ_G0024039
protein coding gene Chr19:35033967-35052075 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023839
protein coding gene Chr19:35452968-35469828 (+)
WSB/EiJ MGP_WSBEiJ_G0024354
protein coding gene Chr19:36694969-36715444 (+)



Homology
more
  • Human Ortholog
    FFAR4, free fatty acid receptor 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FFAR4, free fatty acid receptor 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BMIQ10, GPR120, GPR129, GT01, O3FAR1, PGR4
  • Links
    NCBI Gene ID: 338557
    neXtProt AC: NX_Q5NUL3
    UniProt: Q5NUL3

  • Chr Location
    10q23.33; chr10:93566179-93590072 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 5 alleles in 5 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show altered taste responses to fatty acids. Homozygotes for another null allele develop obesity, liver steatosis, and impaired glucose metabolism, adipogenesis and lipogenesis on a high-fat diet. Homozygotes for a third allele show altered islet somatostatin secretion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 107221 NCBI Gene Model | MGI Sequence Detail 17185 C57BL/6J ±  kb
transcript NM_181748 RefSeq | MGI Sequence Detail 1393 C57BL/6  
polypeptide Q7TMA4 UniProt | EBI | MGI Sequence Detail 361 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 3
References
more
  • Summaries
    All 71
    Gene Ontology 11
    Phenotypes 27
  • Earliest
    J:83410 Vassilatis DK, et al., The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4903-8
  • Latest
    J:265430 Ho JD, et al., Structural basis for GPR40 allosteric agonism and incretin stimulation. Nat Commun. 2018 Apr 25;9(1):1645

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory