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Uqcc3 Gene Detail
Summary
  • Symbol
    Uqcc3
  • Name
    ubiquinol-cytochrome c reductase complex assembly factor 3
  • Synonyms
    AI462493, Cbp4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147553
    NCBI Gene: 107197
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:8857378-8858287 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.90 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147553
 protein coding gene Chr19:8857378-8858297 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024817
 protein coding gene Chr19:6164289-6165206 (-)
A/J MGP_AJ_G0024785
 protein coding gene Chr19:5831927-5832844 (-)
AKR/J MGP_AKRJ_G0024760
 protein coding gene Chr19:5927884-5928801 (-)
BALB/cJ MGP_BALBcJ_G0024785
 protein coding gene Chr19:5938953-5939870 (-)
C3H/HeJ MGP_C3HHeJ_G0024551
 protein coding gene Chr19:6013856-6014773 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025232
 protein coding gene Chr19:6300694-6301611 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022661
 protein coding gene Chr19:6085683-6086581 (-)
CAST/EiJ MGP_CASTEiJ_G0024024
 protein coding gene Chr19:5664686-5665604 (-)
CBA/J MGP_CBAJ_G0024525
 protein coding gene Chr19:6410288-6411205 (-)
DBA/2J MGP_DBA2J_G0024652
 protein coding gene Chr19:5664579-5665496 (-)
FVB/NJ MGP_FVBNJ_G0024619
 protein coding gene Chr19:5737054-5737971 (-)
LP/J MGP_LPJ_G0024739
 protein coding gene Chr19:6059321-6060238 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024646
 protein coding gene Chr19:6274441-6275358 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025281
 protein coding gene Chr19:5972590-5973507 (-)
PWK/PhJ MGP_PWKPhJ_G0023769
 protein coding gene Chr19:5338641-5339559 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023574
 protein coding gene Chr19:5581378-5582306 (-)
WSB/EiJ MGP_WSBEiJ_G0024086
 protein coding gene Chr19:5945166-5946083 (-)



Homology
more
  • Human Ortholog
    UQCC3, ubiquinol-cytochrome c reductase complex assembly factor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UQCC3, ubiquinol-cytochrome c reductase complex assembly factor 3
  • Synonyms
    C11orf83, CCDS41658.1, MC3DN9, UNQ655
  • Links
    NCBI Gene ID: 790955
    neXtProt AC: NX_Q6UW78
    UniProt: Q6UW78

  • Chr Location
    11q12.3; chr11:62670273-62673686 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human UQCC3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    63
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071654 Ensembl Gene Model | MGI Sequence Detail 910 C57BL/6J ±  kb
    transcript ENSMUST00000096253 Ensembl | MGI Sequence Detail 821 Not Applicable  
    polypeptide ENSMUSP00000093972 Ensembl | MGI Sequence Detail 89 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000059871 ubiquinol-cytochrome-c reductase complex assembly factor 3
      (term hierarchy)
    • InterPro Domains
      IPR027896 Ubiquinol-cytochrome-c reductase complex assembly factor 3
    Molecular
    Reagents
    less
    • All nucleic 63
      cDNA 63

      Microarray probesets 3
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:338877 Zhang G, et al., Mitochondrial UQCC3 controls embryonic and tumor angiogenesis by regulating VEGF expression. iScience. 2023 Aug 18;26(8):107370
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory