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Btaf1 Gene Detail
Summary
  • Symbol
    Btaf1
  • Name
    B-TFIID TATA-box binding protein associated factor 1
  • Synonyms
    E430027O22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147538
    NCBI Gene: 107182
  • Gene Overview
    MyGene.info: BTAF1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:36926079-37012752 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 32.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    363 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147538
protein coding gene Chr19:36926079-37014057 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025076
protein coding gene Chr19:35842689-35940566 (+)
A/J MGP_AJ_G0025052
protein coding gene Chr19:34122844-34212709 (+)
AKR/J MGP_AKRJ_G0025020
protein coding gene Chr19:35279543-35377900 (+)
BALB/cJ MGP_BALBcJ_G0025050
protein coding gene Chr19:34207487-34297508 (+)
C3H/HeJ MGP_C3HHeJ_G0024809
protein coding gene Chr19:35337779-35431195 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025491
protein coding gene Chr19:36875069-36975164 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022909
protein coding gene Chr19:33486431-33573659 (+)
CAST/EiJ MGP_CASTEiJ_G0024276
protein coding gene Chr19:35171094-35267078 (+)
CBA/J MGP_CBAJ_G0024786
protein coding gene Chr19:38626784-38722956 (+)
DBA/2J MGP_DBA2J_G0024918
protein coding gene Chr19:33981611-34068858 (+)
FVB/NJ MGP_FVBNJ_G0024879
protein coding gene Chr19:33790342-33880721 (+)
LP/J MGP_LPJ_G0025004
protein coding gene Chr19:35938675-36045127 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024910
protein coding gene Chr19:38450309-38547753 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025549
protein coding gene Chr19:35370919-35464698 (+)
PWK/PhJ MGP_PWKPhJ_G0024028
protein coding gene Chr19:33811996-33903428 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023828
protein coding gene Chr19:34195095-34287601 (+)
WSB/EiJ MGP_WSBEiJ_G0024343
protein coding gene Chr19:35463584-35553592 (+)



Homology
more
  • Human Ortholog
    BTAF1, B-TFIID TATA-box binding protein associated factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BTAF1, B-TFIID TATA-box binding protein associated factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MOT1, TAF172, TAFII170, TAF(II)170
  • Links
    NCBI Gene ID: 9044
    neXtProt AC: NX_O14981
    UniProt: O14981

  • Chr Location
    10q23.32; chr10:91923769-92030998 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31978
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BTAF1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a gene-trapped allele display growth retardation. Embryos homozygous for an ENU-induced allele show growth retardation, edema, abnormal blood circulation, myocardial trabeculae hypoplasia, and delayed head and brain development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040565 Ensembl Gene Model | MGI Sequence Detail 86674 C57BL/6J ±  kb
    transcript ENSMUST00000099494 Ensembl | MGI Sequence Detail 7204 Not Applicable  
    polypeptide ENSMUSP00000097093 Ensembl | MGI Sequence Detail 1848 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR022707 Domain of unknown function DUF3535
      IPR001650 Helicase, C-terminal
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR038718 SNF2-like, N-terminal domain superfamily
      IPR000330 SNF2-related, N-terminal domain
    Molecular
    Reagents
    less
    • All nucleic 126
      cDNA 124
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2147520
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 8
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:173663 Wansleeben C, et al., An ENU-induced point mutation in the mouse Btaf1 gene causes post-gastrulation embryonic lethality and protein instability. Mech Dev. 2011 May-Jun;128(5-6):279-88

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory