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Wdr74 Gene Detail
Summary
  • Symbol
    Wdr74
  • Name
    WD repeat domain 74
  • Synonyms
    5730436H21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147427
    NCBI Gene: 107071
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:8735827-8740624 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 5.44 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    23 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147427
protein coding gene Chr19:8735795-8740624 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024804
protein coding gene Chr19:6007841-6012623 (+)
A/J MGP_AJ_G0024772
protein coding gene Chr19:5687402-5692601 (+)
AKR/J MGP_AKRJ_G0024747
protein coding gene Chr19:5776212-5780932 (+)
BALB/cJ MGP_BALBcJ_G0024772
protein coding gene Chr19:5790359-5795371 (+)
C3H/HeJ MGP_C3HHeJ_G0024538
protein coding gene Chr19:5856927-5861743 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025219
protein coding gene Chr19:6126850-6132139 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022648
protein coding gene Chr19:5929271-5933882 (+)
CAST/EiJ MGP_CASTEiJ_G0024011
protein coding gene Chr19:5504420-5508989 (+)
CBA/J MGP_CBAJ_G0024512
protein coding gene Chr19:6242861-6247438 (+)
DBA/2J MGP_DBA2J_G0024639
protein coding gene Chr19:5518261-5522838 (+)
FVB/NJ MGP_FVBNJ_G0024606
protein coding gene Chr19:5593765-5598484 (+)
LP/J MGP_LPJ_G0024726
protein coding gene Chr19:5896297-5901016 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024633
protein coding gene Chr19:6112866-6117588 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025268
protein coding gene Chr19:5820511-5825742 (+)
PWK/PhJ MGP_PWKPhJ_G0023756
protein coding gene Chr19:5183562-5188147 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023561
protein coding gene Chr19:5418156-5422741 (+)
WSB/EiJ MGP_WSBEiJ_G0024073
protein coding gene Chr19:5784367-5790066 (+)



Homology
more
  • Human Ortholog
    WDR74, WD repeat domain 74
  • Vertebrate Orthologs
    9
  • Human Ortholog
    WDR74, WD repeat domain 74
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Nsa1
  • Links
    NCBI Gene ID: 54663
    neXtProt AC: NX_Q6RFH5
    UniProt: Q6RFH5

  • Chr Location
    11q12.3; chr11:62832905-62841809 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042729 Ensembl Gene Model | MGI Sequence Detail 4798 C57BL/6J ±  kb
transcript ENSMUST00000049424 Ensembl | MGI Sequence Detail 1204 Not Applicable  
polypeptide ENSMUSP00000043315 Ensembl | MGI Sequence Detail 384 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR001680 WD40 repeat
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    IPR037379 WDR74/Nsa1
Molecular
Reagents
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  • All nucleic 65
    cDNA 63
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:244597 Cui W, et al., Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Sci Rep. 2016 Nov 21;6:37396

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory