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Slc6a7 Gene Detail
Summary
  • Symbol
    Slc6a7
  • Name
    solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
  • Synonyms
    MGC:61029, MGC:67444, Prot
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147363
    NCBI Gene: 240332
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:61128452-61147294 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 34.41 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    142 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147363
 protein coding gene Chr18:61128448-61147484 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024472
 protein coding gene Chr18:60850376-60869220 (-)
A/J MGP_AJ_G0024439
 protein coding gene Chr18:58241223-58260433 (-)
AKR/J MGP_AKRJ_G0024409
 protein coding gene Chr18:59847677-59866545 (-)
BALB/cJ MGP_BALBcJ_G0024438
 protein coding gene Chr18:58365951-58386509 (-)
C3H/HeJ MGP_C3HHeJ_G0024206
 protein coding gene Chr18:60073727-60092546 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024885
 protein coding gene Chr18:62504421-62523230 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022316
 protein coding gene Chr18:57783868-57802965 (-)
CAST/EiJ MGP_CASTEiJ_G0023679
 protein coding gene Chr18:59943009-59963751 (-)
CBA/J MGP_CBAJ_G0024176
 protein coding gene Chr18:64512722-64531649 (-)
DBA/2J MGP_DBA2J_G0024306
 protein coding gene Chr18:57911265-57930069 (-)
FVB/NJ MGP_FVBNJ_G0024272
 protein coding gene Chr18:57319376-57338199 (-)
LP/J MGP_LPJ_G0024389
 protein coding gene Chr18:60698177-60717043 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024301
 protein coding gene Chr18:66139151-66159344 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024932
 protein coding gene Chr18:60039657-60060108 (-)
PWK/PhJ MGP_PWKPhJ_G0023422
 protein coding gene Chr18:58137547-58157017 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023228
 protein coding gene Chr18:60267690-60286701 (-)
WSB/EiJ MGP_WSBEiJ_G0023743
 protein coding gene Chr18:59894929-59913765 (-)



Homology
more
  • Human Ortholog
    SLC6A7, solute carrier family 6 member 7
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC6A7, solute carrier family 6 member 7
  • Synonyms
    PROT
  • Links
    NCBI Gene ID: 6534
    neXtProt AC: NX_Q99884
    UniProt: Q99884

  • Chr Location
    5q32; chr5:150189861-150211072 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele display reduced uptake of L-proline in the brain, reduced responses to novelty, and impaired extinction of spatial memory. Mice homozygous for a second null allele display partial preweaning lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    17
  • cDNA Data
    11
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052026 Ensembl Gene Model | MGI Sequence Detail 18843 C57BL/6J ±  kb
    transcript ENSMUST00000025520 Ensembl | MGI Sequence Detail 3366 Not Applicable  
    polypeptide ENSMUSP00000025520 Ensembl | MGI Sequence Detail 637 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 2

      Microarray probesets 1
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:288931 Schulz D, et al., Inactivation of the Mouse L-Proline Transporter PROT Alters Glutamatergic Synapse Biochemistry and Perturbs Behaviors Required to Respond to Environmental Changes. Front Mol Neurosci. 2018;11:279
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/28/2022
    MGI 6.20     		The Jackson Laboratory