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Me2
Gene Detail
Symbol

Name
ID
Me2
malic enzyme 2, NAD(+)-dependent, mitochondrial
MGI:2147351
Synonyms
D030040L20Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 18
49.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:73770040-73815392 bp, - strand
From NCBI annotation of GRCm38

  45353 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37615  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: malic enzyme
Gene Tree: Me2

Human
homologs
Human Homolog ME2, malic enzyme 2, NAD(+)-dependent, mitochondrial
NCBI Gene ID 4200
neXtProt AC  NX_P23368
Human Synonyms  ODS1
Human Chr (Location)  18q21; chr18:50879062-50949795 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human ME2
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(6) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Me2 interacts with 108 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (190)    Tissues (145)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 190
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000024556 (Evidence)
Entrez Gene107029 (Evidence)
DFCITC1576519, TC1605490, TC1611961, TC1614144, TC1621796, TC1634609, TC1770934
DoTSDT.101184097, DT.40134245, DT.492025, DT.55233201, DT.91327657, DT.94151056
NIA Mouse Gene IndexU038553, U038554
EC1.1.1.38
Consensus CDS ProjectCCDS29339.1
International Mouse Knockout Project StatusMe2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 107029 NCBI Gene Model | MGI Sequence Detail 45353 C57BL/6J ±  kb
transcript NM_145494 RefSeq | MGI Sequence Detail 2455 C57BL/6 
polypeptide Q99KE1 UniProt | EBI | MGI Sequence Detail 589 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(557 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015884 Malic enzyme, conserved site
InterPro IPR012302 Malic enzyme, NAD-binding
InterPro IPR012301 Malic enzyme, N-terminal
InterPro IPR001891 Malic oxidoreductase
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000010274 NAD-dependent malic enzyme, mitochondrial
Graphical View of Protein Domain Structure
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:194552 Jiang P, et al., Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature. 2013 Jan 31;493(7434):689-93
All references(38)
Other
accession IDs
MGI:2442685

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory