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Me2 Gene Detail
Summary
  • Symbol
    Me2
  • Name
    malic enzyme 2, NAD(+)-dependent, mitochondrial
  • Synonyms
    D030040L20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147351
    NCBI Gene: 107029
  • Gene Overview
    MyGene.info: ME2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:73770040-73815392 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 49.95 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    577 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147351
protein coding gene Chr18:73764956-73815591 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024550
protein coding gene Chr18:74364603-74413914 (-)
A/J MGP_AJ_G0024517
protein coding gene Chr18:71123269-71168935 (-)
AKR/J MGP_AKRJ_G0024488
protein coding gene Chr18:73236276-73282672 (-)
BALB/cJ MGP_BALBcJ_G0024517
protein coding gene Chr18:71298650-71344143 (-)
C3H/HeJ MGP_C3HHeJ_G0024285
protein coding gene Chr18:73319556-73365022 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024963
protein coding gene Chr18:76316969-76365693 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022394
protein coding gene Chr18:70225238-70269744 (-)
CAST/EiJ MGP_CASTEiJ_G0023758
protein coding gene Chr18:73492971-73542922 (-)
CBA/J MGP_CBAJ_G0024254
protein coding gene Chr18:78917636-78967386 (-)
DBA/2J MGP_DBA2J_G0024384
protein coding gene Chr18:70722189-70766785 (-)
FVB/NJ MGP_FVBNJ_G0024350
protein coding gene Chr18:70059625-70104483 (-)
LP/J MGP_LPJ_G0024468
protein coding gene Chr18:74237990-74285851 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024380
protein coding gene Chr18:80399740-80448835 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025011
protein coding gene Chr18:73358031-73406248 (-)
PWK/PhJ MGP_PWKPhJ_G0023502
protein coding gene Chr18:71082858-71127124 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023307
protein coding gene Chr18:73509810-73555821 (-)
WSB/EiJ MGP_WSBEiJ_G0023821
protein coding gene Chr18:73319896-73365356 (-)



Homology
more
  • Human Ortholog
    ME2, malic enzyme 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ME2, malic enzyme 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ODS1
  • Links
    NCBI Gene ID: 4200
    neXtProt AC: NX_P23368
    UniProt: P23368

  • Chr Location
    18q21.2; chr18:50878604-50949795 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024556 Ensembl Gene Model | MGI Sequence Detail 45353 C57BL/6J ±  kb
transcript ENSMUST00000025439 Ensembl | MGI Sequence Detail 2455 Not Applicable  
polypeptide ENSMUSP00000025439 Ensembl | MGI Sequence Detail 589 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 20
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2442685
References
more
  • Summaries
    All 39
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:194552 Jiang P, et al., Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature. 2013 Jan 31;493(7434):689-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory