Me2
Gene Detail

Symbol Name ID

Me2 malic enzyme 2, NAD(+)-dependent, mitochondrial MGI:2147351

Synonyms

D030040L20Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 18

49.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr18:73770040-73815392 bp, - strand From NCBI annotation of GRCm38   45353 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37615  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: malic enzyme
Gene Tree: Me2

Human homologs

Human Homolog		ME2, malic enzyme 2, NAD(+)-dependent, mitochondrial
NCBI Gene ID		4200
neXtProt AC		NX_P23368
Human Synonyms		ODS1
Human Chr (Location)		18q21; chr18:48405432-48476165 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human ME2

Alleles and phenotypes

All alleles(8) : Targeted(2) Gene trapped(6)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	malate metabolic process, metabolic process, ...
Component	intracellular membrane-bounded organelle, mitochondrion
Function	catalytic activity, malate dehydrogenase (oxaloacetate-decarboxylating) activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (190)    Tissues (145)    Images (32)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	190

cDNA source data(76)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(77) cDNA(76) Primer pair(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000024556 (Evidence)
Entrez Gene	107029 (Evidence)
UniGene	36817
DFCI	TC1576519, TC1605490, TC1611961, TC1614144, TC1621796, TC1634609
DoTS	DT.101184097, DT.40134245, DT.492025, DT.91327657, DT.94151056
NIA Mouse Gene Index	U038554
EC	1.1.1.38
Consensus CDS Project	CCDS29339.1
International Mouse Knockout Project Status	Me2

Sequences

Length	Strain/Species
genomic	107029	NCBI Gene Model | MGI Sequence Detail	45353	C57BL/6J
transcript	NM_145494	RefSeq | MGI Sequence Detail	2455	C57BL/6
polypeptide	Q99KE1	UniProt | EBI | MGI Sequence Detail	589	Not Applicable

All sequences(37) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(280 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015884	Malic enzyme, conserved site
InterPro	IPR012302	Malic enzyme, NAD-binding
InterPro	IPR012301	Malic enzyme, N-terminal
InterPro	IPR001891	Malic oxidoreductase
InterPro	IPR016040	NAD(P)-binding domain
Protein Ontology	PR:000010274	NAD-dependent malic enzyme, mitochondrial

Graphical View of Protein Domain Structure

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:194552 Jiang P, et al., Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature. 2013 Jan 31;493(7434):689-93
All references(38)

Other accession IDs

MGI:2442685