Me2 MGI Mouse Gene Detail - MGI:2147351 - malic enzyme 2, NAD(+)-dependent, mitochondrial

Symbol

Me2
Name

malic enzyme 2, NAD(+)-dependent, mitochondrial
Synonyms

D030040L20Rik

Feature Type

protein coding gene
IDs

MGI:2147351
NCBI Gene: 107029
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr18:73902974-73948520 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 49.95 cM
Mapping Data

2 experiments

SNPs within 2kb

1571 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2147351	protein coding gene	Chr18:73898025-73949326 (-)
129S1/SvImJ	ENSMUSG00200026940	protein coding gene	Chr18:71122408-71167813 (-)
A/J	ENSMUSG00195004781	protein coding gene	Chr18:71168417-71214000 (-)
AKR/J	ENSMUSG00220016740	protein coding gene	Chr18:71115814-71161323 (-)
BALB/cJ	ENSMUSG00180013168	protein coding gene	Chr18:71747117-71792705 (-)
C3H/HeJ	ENSMUSG00175011648	protein coding gene	Chr18:71314793-71359956 (-)
C57BL/6NJ	ENSMUSG00215009992	protein coding gene	Chr18:70665552-70711096 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022394	protein coding gene	Chr18:70225238-70269744 (-)
CAST/EiJ	ENSTCUG00005014771	protein coding gene	Chr18:70248487-70293477 (-)
CBA/J	ENSMUSG00210031787	protein coding gene	Chr18:71272378-71317543 (-)
DBA/2J	ENSMUSG00185010673	protein coding gene	Chr18:71178484-71223645 (-)
FVB/NJ	ENSMUSG00205012517	protein coding gene	Chr18:70632194-70677579 (-)
JF1/MsJ	ENSUMUG00000017486	protein coding gene	Chr18:71082133-71127278 (-)
LP/J	ENSMUSG00230011086	protein coding gene	Chr18:73246609-73292011 (-)
NOD/ShiLtJ	ENSMUSG00190022227	protein coding gene	Chr18:70914042-70959625 (-)
NZO/HlLtJ	ENSMUSG00225033051	protein coding gene	Chr18:73096416-73141973 (-)
PWK/PhJ	ENSLUMG00010006260	protein coding gene	Chr18:71511281-71555567 (-)
SPRET/EiJ	ENSMSPG00010007884	protein coding gene	Chr18:71735097-71780021 (-)
WSB/EiJ	ENSIUOG00005005919	protein coding gene	Chr18:70721483-70767028 (-)

Human Ortholog

ME2, malic enzyme 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ME2, malic enzyme 2
Synonyms

ODS1
Links

HGNC:6984

NCBI Gene ID: 4200

UniProt: P23368
Chr Location

18q21.2; chr18:50878819-50954257 (+) GRCh38

MGI Vertebrate Homology

Me2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ME2
Protein SuperFamily

ME
Gene Tree

Me2

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (ENU)

1
Endonuclease-mediated

3
Gene trapped

6
Targeted

4
Transposon induced

1
Genomic Mutations

1 involving Me2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

25
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

788
Tissues

145
cDNA Data

20
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase me2

ZFIN me2

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All Sequences

54
RefSeq

7
UniProt

3
CCDS

CCDS29339.1

Ensembl

ENSMUSG00000024556 (Evidence)
NCBI Gene

107029

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024556	Ensembl Gene Model \| MGI Sequence Detail	45547	C57BL/6J	± kb
transcript	ENSMUST00000025439	Ensembl \| MGI Sequence Detail	2638	Not Applicable
polypeptide	ENSMUSP00000025439	Ensembl \| MGI Sequence Detail	589	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010274 NAD-dependent malic enzyme, mitochondrial

(term hierarchy)
EC

1.1.1.38
InterPro Domains

IPR046346 Aminoacid dehydrogenase-like, N-terminal domain superfamily

IPR015884 Malic enzyme, conserved site

IPR012302 Malic enzyme, NAD-binding

IPR012301 Malic enzyme, N-terminal domain

IPR037062 Malic enzyme, N-terminal domain superfamily

IPR001891 Malic oxidoreductase

IPR036291 NAD(P)-binding domain superfamily
GlyGen

Q99KE1 1 site, 1 O-linked glycan (1 site)

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All nucleic 21

cDNA 20

Primer pair 1

Microarray probesets 5

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MGI:2442685

Summaries

All 48

Developmental Gene Expression 5

Gene Ontology 12

Phenotypes 11
Earliest

J:330451 Moreadith RW, et al., Purification, kinetic behavior, and regulation of NAD(P)+ malic enzyme of tumor mitochondria. J Biol Chem. 1984 May 25;259(10):6222-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Me2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr153888	Chr18:73948826-73948865 (-)	-326 bp
Tssr153887	Chr18:73948774-73948785 (-)	-260 bp
Tssr153886	Chr18:73948541-73948557 (-)	-29 bp
Tssr153885	Chr18:73948501-73948524 (-)	7 bp
Tssr153884	Chr18:73903578-73903581 (-)	44,940 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24