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Svil Gene Detail
Summary
  • Symbol
    Svil
  • Name
    supervillin
  • Synonyms
    B430302E16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147319
    NCBI Gene: 225115
  • Gene Overview
    MyGene.info: SVIL
Location & Maps
more
  • Sequence Map
    Chr18:4920540-5119299 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      198760 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SVIL, supervillin
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SVIL, supervillin
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 6840
    neXtProt AC: NX_O95425

  • Chr Location
    10p11.2; chr10:29457338-29736935 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 25090
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: SVIL
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit enhanched adhesion and thrombus formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033148 VEGA Gene Model | MGI Sequence Detail 198760 C57BL/6J ±  kb
transcript OTTMUST00000082891 VEGA | MGI Sequence Detail 7907 Not Applicable  
polypeptide OTTMUSP00000044479 VEGA | MGI Sequence Detail 2170 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1065 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 105
    cDNA 104
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:1925796
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:198612 Edelstein LC, et al., Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress. Circulation. 2012 Jun 5;125(22):2762-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory