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Svil
Gene Detail
 Symbol
Name
ID
Svil
supervillin
MGI:2147319
Synonyms B430302E16Rik
Feature Type protein coding gene
Genetic Map
Chromosome 18
3.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:4920540-5119299 bp, + strand
From VEGA annotation of GRCm38

  198760 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:25090  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Svil

Human
homologs
Human Homolog SVIL, supervillin
NCBI Gene ID 6840
neXtProt AC  NX_O95425
Human Chr (Location)  10p11.2; chr10:29457338-29736935 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(53) : Gene trapped(50) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit enhanched adhesion and thrombus formation.
 
Interactions
Svil interacts with 307 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cytoskeleton organization, skeletal muscle tissue development
Component actin cytoskeleton, cell junction, ...
Function actin binding, actin filament binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (171)    Tissues (16)    Images (25)
Theiler Stages: 22, 23, 26, 28
Assay TypeResults
RNA in situ 166
RT-PCR 5
cDNA source data(102)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(104) cDNA(103) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000033148 (Evidence)
Ensembl Gene ModelENSMUSG00000024236 (Evidence)
Entrez Gene225115 (Evidence)
UniGene136791
DFCITC1575971, TC1591591, TC1636129, TC1679201
DoTSDT.101342655, DT.101735222, DT.493365, DT.91334693, DT.91364623
NIA Mouse Gene IndexU018366
Consensus CDS ProjectCCDS29038.1, CCDS37720.1
International Mouse Knockout Project StatusSvil
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033148 VEGA Gene Model | MGI Sequence Detail 198760 C57BL/6J ±  kb
transcript OTTMUST00000082891 VEGA | MGI Sequence Detail 7907 Not Applicable 
polypeptide OTTMUSP00000044479 VEGA | MGI Sequence Detail 2170 Not Applicable 

For the selected sequences
All sequences(142) RefSeq(48) UniProt(14)
Polymorphisms SNPs within 2kb(1070 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007123 Gelsolin domain
InterPro IPR015628 Supervillin
InterPro IPR007122 Villin/Gelsolin
InterPro IPR003128 Villin headpiece
Protein Ontology PR:000015853 supervillin
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:198612 Edelstein LC, et al., Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress. Circulation. 2012 Jun 5;125(22):2762-71
All references(42)
Other
accession IDs
MGI:1925796

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory