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Arap3 Gene Detail
Summary
  • Symbol
    Arap3
  • Name
    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
  • Synonyms
    Centd3, DRAG1, E030006K04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147274
    NCBI Gene: 106952
  • Gene Overview
    MyGene.info: ARAP3
Location & Maps
more
  • Sequence Map
    Chr18:37972624-37997574 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24951 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 19.85 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ARAP3, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARAP3, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CENTD3, DRAG1
  • Links
    NCBI Gene ID: 64411
    neXtProt AC: NX_Q8WWN8

  • Chr Location
    5q31.3; chr5:141653401-141682233 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 11199
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ARAP3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Endonuclease-mediated
    1
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for a knock-out allele die around E11 exhibiting pallor, embryonic growth arrest, yolk sac and placental abnormalities, and an endothelial cell-autonomous defect in sprouting angiogenesis. Knock-in mice homozygous for a point mutation display similar angiogenesis defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024451 Ensembl Gene Model | MGI Sequence Detail 24951 C57BL/6J ±  kb
transcript ENSMUST00000042944 Ensembl | MGI Sequence Detail 5224 Not Applicable  
polypeptide ENSMUSP00000035662 Ensembl | MGI Sequence Detail 1538 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    121 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004195 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
  • InterPro Domains
    IPR001164 Arf GTPase activating protein
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
    IPR000159 Ras-associating (RA) domain
    IPR000198 Rho GTPase-activating protein domain
    IPR008936 Rho GTPase activation protein
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain
    IPR029071 Ubiquitin-related domain
Molecular
Reagents
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  • All nucleic 26
    cDNA 26

    Microarray probesets 5
Other
Accession IDs
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MGI:2444395
References
more
  • Summaries
    All 32
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:206218 Kartopawiro J, et al., Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Hum Mol Genet. 2014 Mar 1;23(5):1286-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory