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Arap3
Gene Detail
 Symbol
Name
ID
Arap3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
MGI:2147274
Synonyms Centd3, DRAG1, E030006K04Rik
Feature Type protein coding gene
Genetic Map
Chromosome 18
19.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:37972624-37997574 bp, - strand
From Ensembl annotation of GRCm38

  24951 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11199  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Arap3

Human
homologs
Human Homolog ARAP3, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
NCBI Gene ID 64411
neXtProt AC  NX_Q8WWN8
Human Synonyms  CENTD3, DRAG1
Human Chr (Location)  5q31.3; chr5:141653401-141682233 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele die around E11 exhibiting pallor, embryonic growth arrest, yolk sac and placental abnormalities, and an endothelial cell-autonomous defect in sprouting angiogenesis. Knock-in mice homozygous for a point mutation display similar angiogenesis defects.
 
Interactions
Arap3 interacts with 85 markers (Mir16-2, Mir18, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process negative regulation of cell migration, negative regulation of Rac protein signal transduction, ...
Component cell projection, cytoplasm, ...
Function ARF GTPase activator activity, GTPase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (24)    Tissues (2)    Images (24)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 24
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(26)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000024451 (Evidence)
Entrez Gene106952 (Evidence)
UniGene247642
DFCITC1582122, TC1592283, TC1596873, TC1601393, TC1602827, TC1672382
DoTSDT.101724602, DT.110777471, DT.110777473, DT.526564, DT.91423791, DT.91559406, DT.91578112
NIA Mouse Gene IndexU038356
Consensus CDS ProjectCCDS29196.1
International Mouse Knockout Project StatusArap3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024451 Ensembl Gene Model | MGI Sequence Detail 24951 C57BL/6J ±  kb
transcript ENSMUST00000042944 Ensembl | MGI Sequence Detail 5224 Not Applicable 
polypeptide ENSMUSP00000035662 Ensembl | MGI Sequence Detail 1538 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(18) UniProt(3)
Polymorphisms SNPs within 2kb(120 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001164 Arf GTPase activating protein
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000159 Ras-association
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011510 Sterile alpha motif, type 2
Protein Ontology PR:000004195 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:206218 Kartopawiro J, et al., Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Hum Mol Genet. 2014 Mar 1;23(5):1286-97
All references(36)
Other
accession IDs
MGI:2444395

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory