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Arap3 Gene Detail
Summary
  • Symbol
    Arap3
  • Name
    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
  • Synonyms
    Centd3, DRAG1, E030006K04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147274
    NCBI Gene: 106952
  • Gene Overview
    MyGene.info: ARAP3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:37972624-37997574 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24951 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 19.85 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ARAP3, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ARAP3, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CENTD3, DRAG1
  • Links
    NCBI Gene ID: 64411
    neXtProt AC: NX_Q8WWN8
    UniProt: Q8WWN8

  • Chr Location
    5q31.3; chr5:141653401-141682233 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die around E11 exhibiting pallor, embryonic growth arrest, yolk sac and placental abnormalities, and an endothelial cell-autonomous defect in sprouting angiogenesis. Knock-in mice homozygous for a point mutation display similar angiogenesis defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024451 Ensembl Gene Model | MGI Sequence Detail 24951 C57BL/6J ±  kb
    transcript ENSMUST00000042944 Ensembl | MGI Sequence Detail 5224 Not Applicable  
    polypeptide ENSMUSP00000035662 Ensembl | MGI Sequence Detail 1538 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      121 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 27

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2444395
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:237548 Song Y, et al., ARAP3 functions in hematopoietic stem cells. PLoS One. 2014;9(12):e116107

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory