Slc39a3
Gene Detail

Symbol Name ID

Slc39a3 solute carrier family 39 (zinc transporter), member 3 MGI:2147269

Synonyms

MGC:7461, zip3

Feature Type

protein coding gene

Genetic Map

Chromosome 10

39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:81028538-81037426 bp, - strand From VEGA annotation of GRCm38   8889 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:44230  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Gene Tree: Slc39a3

Human homologs

Human Homolog		SLC39A3, solute carrier family 39 (zinc transporter), member 3
NCBI Gene ID		29985
neXtProt AC		NX_Q9BRY0
Human Synonyms		ZIP3
Human Chr (Location)		19p13.3; chr19:2732522-2740074 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Homozygous null mice stressed with a zinc-deficient diet during pregnancy or at weaning exhibit a subtle increase in the sensitivity to abnormal morphogenesis of the embryo and to depletion of thymic pre-T cells, respectively.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	ion transport, metal ion transport, ...
Component	integral to membrane, membrane
Function	metal ion transmembrane transporter activity, zinc ion transmembrane transporter activity

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (211)    Tissues (127)    Images (37)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	194
In situ reporter (knock in)	11
Northern blot	6

cDNA source data(54)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(55) cDNA(55)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000030300 (Evidence)
Ensembl Gene Model	ENSMUSG00000046822 (Evidence)
Entrez Gene	106947 (Evidence)
UniGene	5353
DFCI	TC1577373
DoTS	DT.529201
NIA Mouse Gene Index	U032031
Consensus CDS Project	CCDS24041.1
International Mouse Knockout Project Status	Slc39a3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030300	VEGA Gene Model | MGI Sequence Detail	8889	C57BL/6J
transcript	OTTMUST00000075012	VEGA | MGI Sequence Detail	3796	Not Applicable
polypeptide	OTTMUSP00000039253	VEGA | MGI Sequence Detail	317	Not Applicable

All sequences(33) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(29 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003689	Zinc/iron permease
Protein Ontology	PR:000015130	zinc transporter ZIP3

References

(Earliest) J:87178 Dufner-Beattie J, et al., Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J Biol Chem. 2003 Dec 12;278(50):50142-50
(Latest) J:167854 Qian J, et al., Knockout of Zn transporters Zip-1 and Zip-3 attenuates seizure-induced CA1 neurodegeneration. J Neurosci. 2011 Jan 5;31(1):97-104
All references(38)