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Tnfaip8 Gene Detail
Summary
  • Symbol
    Tnfaip8
  • Name
    tumor necrosis factor, alpha-induced protein 8
  • Synonyms
    E130304C20Rik, Gg2-1, Gm10539, Nded, Ssc-2, Tipe
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147191
    NCBI Gene: 106869
  • Gene Overview
    MyGene.info: TNFAIP8
  • Alliance
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:49979427-50093229 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 27.18 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1090 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147191
protein coding gene Chr18:49979427-50107173 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024420
protein coding gene Chr18:48992608-49127569 (+)
A/J MGP_AJ_G0024386
protein coding gene Chr18:47139833-47271792 (+)
AKR/J MGP_AKRJ_G0024356
protein coding gene Chr18:48448034-48583689 (+)
BALB/cJ MGP_BALBcJ_G0024386
protein coding gene Chr18:47269090-47400443 (+)
C3H/HeJ MGP_C3HHeJ_G0024153
protein coding gene Chr18:48578480-48712370 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024832
protein coding gene Chr18:50635539-50769806 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022265
protein coding gene Chr18:46844780-46958335 (+)
CAST/EiJ MGP_CASTEiJ_G0023628
protein coding gene Chr18:48555797-48688864 (+)
CBA/J MGP_CBAJ_G0024123
protein coding gene Chr18:52108732-52255409 (+)
DBA/2J MGP_DBA2J_G0024253
protein coding gene Chr18:46782372-46911522 (+)
FVB/NJ MGP_FVBNJ_G0024220
protein coding gene Chr18:46333332-46462780 (+)
LP/J MGP_LPJ_G0024338
protein coding gene Chr18:49012311-49147567 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024250
protein coding gene Chr18:53642059-53774439 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024879
protein coding gene Chr18:48413868-48546590 (+)
PWK/PhJ MGP_PWKPhJ_G0023371
protein coding gene Chr18:46908443-47040566 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023177
protein coding gene Chr18:48627676-48779105 (+)
WSB/EiJ MGP_WSBEiJ_G0023691
protein coding gene Chr18:48302972-48437131 (+)



Homology
more
  • Human Ortholog
    TNFAIP8, TNF alpha induced protein 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TNFAIP8, TNF alpha induced protein 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GG2-1, MDC-3.13, NDED, SCCS2, SCC-S2
  • Links
    NCBI Gene ID: 25816
    neXtProt AC: NX_O95379
    UniProt: O95379

  • Chr Location
    5q23.1; chr5:119268692-119394604 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to induced colitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 106869 NCBI Gene Model | MGI Sequence Detail 113803 C57BL/6J ±  kb
    transcript NM_001360935 RefSeq | MGI Sequence Detail 3410 C57BL/6  
    polypeptide Q921Z5 UniProt | EBI | MGI Sequence Detail 198 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • PDB
    • InterPro Domains
      IPR038355 TNFAIP8 superfamily
      IPR008477 Tumor necrosis factor alpha-induced protein 8-like
    Molecular
    Reagents
    less
    • All nucleic 88
      cDNA 88

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:3642692
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:223320 Sun H, et al., Exacerbated experimental colitis in TNFAIP8-deficient mice. J Immunol. 2015 Jun 15;194(12):5736-42

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory