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Dhx57 Gene Detail
Summary
  • Symbol
    Dhx57
  • Name
    DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147067
    NCBI Gene: 106794
  • Gene Overview
    MyGene.info: DHX57
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:80238304-80290476 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 50.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    328 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147067
 protein coding gene Chr17:80238304-80290476 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024060
 protein coding gene Chr17:83148666-83202111 (-)
A/J MGP_AJ_G0024017
 protein coding gene Chr17:80595749-80660143 (-)
AKR/J MGP_AKRJ_G0023986
 protein coding gene Chr17:81854268-81912816 (-)
BALB/cJ MGP_BALBcJ_G0024019
 protein coding gene Chr17:80470709-80522300 (-)
C3H/HeJ MGP_C3HHeJ_G0023783
 protein coding gene Chr17:82733430-82785667 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024463
 protein coding gene Chr17:86183915-86239525 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021904
 protein coding gene Chr17:75968426-76017698 (-)
CAST/EiJ MGP_CASTEiJ_G0023263
 protein coding gene Chr17:83412009-83462936 (-)
CBA/J MGP_CBAJ_G0023757
 protein coding gene Chr17:89769788-89829364 (-)
DBA/2J MGP_DBA2J_G0023886
 protein coding gene Chr17:79101894-79154657 (-)
FVB/NJ MGP_FVBNJ_G0023852
 protein coding gene Chr17:78601814-78653566 (-)
LP/J MGP_LPJ_G0023969
 protein coding gene Chr17:83991084-84041553 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023880
 protein coding gene Chr17:89819018-89873308 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024508
 protein coding gene Chr17:82330742-82393327 (-)
PWK/PhJ MGP_PWKPhJ_G0023009
 protein coding gene Chr17:78638316-78692029 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022820
 protein coding gene Chr17:79113931-79168704 (-)
WSB/EiJ MGP_WSBEiJ_G0023330
 protein coding gene Chr17:83160927-83214833 (-)



Homology
more
  • Human Ortholog
    DHX57, DExH-box helicase 57
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DHX57, DExH-box helicase 57
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DDX57
  • Links
    NCBI Gene ID: 90957
    neXtProt AC: NX_Q6P158
    UniProt: Q6P158

  • Chr Location
    2p22.1; chr2:38797729-38875883 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 56267
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DHX57
  • Gene Tree
    Dhx57
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    40
  • Tissues
    27
  • cDNA Data
    98
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 106794 NCBI Gene Model | MGI Sequence Detail 52173 C57BL/6J ±  kb
transcript NM_001163759 RefSeq | MGI Sequence Detail 5094 C57BL/6  
polypeptide Q6P5D3 UniProt | EBI | MGI Sequence Detail 1388 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 98
    cDNA 98

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
01/15/2019
MGI 6.13 		The Jackson Laboratory