Dhx57
Gene Detail

Symbol Name ID

Dhx57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 MGI:2147067

Feature Type

protein coding gene

Genetic Map

Chromosome 17

50.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr17:80238304-80290476 bp, - strand From NCBI annotation of GRCm38   52173 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56267  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dhx57

Human homologs

Human Homolog		DHX57, DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
NCBI Gene ID		90957
neXtProt AC		NX_Q6P158
Human Synonyms		DDX57
Human Chr (Location)		2p22.1; chr2:38797729-38875879 (-)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(25) : Gene trapped(25)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Dhx57 interacts with 119 markers (Mir17, Mir19a, Mir19b-1, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	biological_process
Component	cellular_component
Function	ATP binding, helicase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)

Data Summary: Results (40)    Tissues (27)    Images (13)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	40

cDNA source data(97)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular reagents

All nucleic(97) cDNA(97)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000035051 (Evidence)
Entrez Gene	106794 (Evidence)
UniGene	12412
DFCI	TC1577617, TC1592991, TC1593241, TC1603836, TC1652379
DoTS	DT.101142181, DT.523895, DT.91306145, DT.91355173, DT.94122023, DT.99852772
NIA Mouse Gene Index	U038082
EC	3.6.4.13
Consensus CDS Project	CCDS28990.1, CCDS50188.1
International Mouse Knockout Project Status	Dhx57

Sequences

Length	Strain/Species
genomic	106794	NCBI Gene Model | MGI Sequence Detail	52173	C57BL/6J
transcript	NM_001163759	RefSeq | MGI Sequence Detail	5094	C57BL/6
polypeptide	Q6P5D3	UniProt | EBI | MGI Sequence Detail	1388	Not Applicable

All sequences(51) RefSeq(17) UniProt(1)

Polymorphisms

SNPs within 2kb(329 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR011545	DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro	IPR011709	Domain of unknown function DUF1605
InterPro	IPR007502	Helicase-associated domain
InterPro	IPR001650	Helicase, C-terminal
InterPro	IPR014001	Helicase, superfamily 1/2, ATP-binding domain
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR006575	RWD domain
InterPro	IPR009060	UBA-like
InterPro	IPR015940	Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
InterPro	IPR000571	Zinc finger, CCCH-type
Protein Ontology	PR:000029415	ATP-dependent RNA helicase DHX57

Graphical View of Protein Domain Structure

References

(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(30)