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Dhx57
Gene Detail
Symbol

Name
ID
Dhx57
DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
MGI:2147067
Feature Type
protein coding gene
Genetic Map
Chromosome 17
50.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:80238304-80290476 bp, - strand
From NCBI annotation of GRCm38

  52173 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56267  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dhx57

Human
homologs
Human Homolog DHX57, DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
NCBI Gene ID 90957
neXtProt AC  NX_Q6P158
Human Synonyms  DDX57
Human Chr (Location)  2p22.1; chr2:38797729-38875879 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(25)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Dhx57 interacts with 119 markers (Mir17, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process RNA processing
Component mitochondrion
Function ATP binding, ATP-dependent RNA helicase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (40)    Tissues (27)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 40
cDNA source data(97)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(97) cDNA(97)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000035051 (Evidence)
Entrez Gene106794 (Evidence)
UniGene12412
DFCITC1593241, TC1603836, TC1592991, TC1652379, TC1577617
DoTSDT.101142181, DT.523895, DT.91306145, DT.91355173, DT.94122023, DT.99852772
NIA Mouse Gene IndexU038082
EC3.6.4.13
Consensus CDS ProjectCCDS28990.1, CCDS50188.1
International Mouse Knockout Project StatusDhx57
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 106794 NCBI Gene Model | MGI Sequence Detail 52173 C57BL/6J ±  kb
transcript NM_001163759 RefSeq | MGI Sequence Detail 5094 C57BL/6 
polypeptide Q6P5D3 UniProt | EBI | MGI Sequence Detail 1388 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(17) UniProt(1)
Polymorphisms
SNPs within 2kb(329 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro IPR011709 Domain of unknown function DUF1605
InterPro IPR007502 Helicase-associated domain
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR006575 RWD domain
InterPro IPR009060 UBA-like
InterPro IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
InterPro IPR000571 Zinc finger, CCCH-type
Protein Ontology PR:000029415 ATP-dependent RNA helicase DHX57
Graphical View of Protein Domain Structure
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory