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Dhx57 Gene Detail
Summary
  • Symbol
    Dhx57
  • Name
    DExH-box helicase 57
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147067
    NCBI Gene: 106794
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:80545733-80597620 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 50.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2836 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147067
 protein coding gene Chr17:80545733-80597905 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024060
 protein coding gene Chr17:83148666-83202111 (-)
A/J MGP_AJ_G0024017
 protein coding gene Chr17:80595749-80660143 (-)
AKR/J MGP_AKRJ_G0023986
 protein coding gene Chr17:81854268-81912816 (-)
BALB/cJ MGP_BALBcJ_G0024019
 protein coding gene Chr17:80470709-80522300 (-)
C3H/HeJ MGP_C3HHeJ_G0023783
 protein coding gene Chr17:82733430-82785667 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024463
 protein coding gene Chr17:86183915-86239525 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021904
 protein coding gene Chr17:75968426-76017698 (-)
CAST/EiJ MGP_CASTEiJ_G0023263
 protein coding gene Chr17:83412009-83462936 (-)
CBA/J MGP_CBAJ_G0023757
 protein coding gene Chr17:89769788-89829364 (-)
DBA/2J MGP_DBA2J_G0023886
 protein coding gene Chr17:79101894-79154657 (-)
FVB/NJ MGP_FVBNJ_G0023852
 protein coding gene Chr17:78601814-78653566 (-)
LP/J MGP_LPJ_G0023969
 protein coding gene Chr17:83991084-84041553 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023880
 protein coding gene Chr17:89819018-89873308 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024508
 protein coding gene Chr17:82330742-82393327 (-)
PWK/PhJ MGP_PWKPhJ_G0023009
 protein coding gene Chr17:78638316-78692029 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022820
 protein coding gene Chr17:79113931-79168704 (-)
WSB/EiJ MGP_WSBEiJ_G0023330
 protein coding gene Chr17:83160927-83214833 (-)



Homology
more
  • Human Ortholog
    DHX57, DExH-box helicase 57
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DHX57, DExH-box helicase 57
  • Synonyms
    DDX57
  • Links
    NCBI Gene ID: 90957
    UniProt: Q6P158

  • Chr Location
    2p22.1; chr2:38797729-38875934 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    28
  • cDNA Data
    98
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 106794 NCBI Gene Model | MGI Sequence Detail 51888 C57BL/6J ±  kb
    transcript NM_001410326 RefSeq | MGI Sequence Detail 5099 C57BL/6  
    polypeptide Q6P5D3 UniProt | EBI | MGI Sequence Detail 1388 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 98
      cDNA 98

      Microarray probesets 3
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/18/2025
    MGI 6.24     		The Jackson Laboratory