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Stap2 Gene Detail
Summary
  • Symbol
    Stap2
  • Name
    signal transducing adaptor family member 2
  • Synonyms
    STAP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147039
    NCBI Gene: 106766
  • Gene Overview
    MyGene.info: STAP2
Location & Maps
more
  • Sequence Map
    Chr17:55997081-56005570 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8490 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.10 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    STAP2, signal transducing adaptor family member 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    STAP2, signal transducing adaptor family member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BKS
  • Links
    NCBI Gene ID: 55620
    neXtProt AC: NX_Q9UGK3

  • Chr Location
    19p13.3; chr19:4324043-4338877 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
  • All Mutations and Alleles
    6
  • Gene trapped
    2
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for a knock-out allele are viable and fertile and display no apparent abnormalities in most organs at the gross and histological level.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038781 Ensembl Gene Model | MGI Sequence Detail 8490 C57BL/6J ±  kb
transcript ENSMUST00000043785 Ensembl | MGI Sequence Detail 1491 Not Applicable  
polypeptide ENSMUSP00000038130 Ensembl | MGI Sequence Detail 411 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    39 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 65
    cDNA 65

    Microarray probesets 5
References
more
  • Summaries
    All 30
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:82584 Minoguchi M, et al., STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif. J Biol Chem. 2003 Mar 28;278(13):11182-9
  • Latest
    J:210230 Sekine Y, et al., Signal-transducing adaptor protein-2 controls the IgE-mediated, mast cell-mediated anaphylactic responses. J Immunol. 2014 Apr 15;192(8):3488-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory