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Mpig6b Gene Detail
Summary
  • Symbol
    Mpig6b
  • Name
    megakaryocyte and platelet inhibitory receptor G6b
  • Synonyms
    AU023871, G6b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146995
    NCBI Gene: 106722
  • Gene Overview
    MyGene.info: MPIG6B
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr17:35062693-35066184 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.59 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146995
protein coding gene Chr17:35062693-35066778 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023611
protein coding gene Chr17:35202504-35207511 (-)
A/J MGP_AJ_G0023571
protein coding gene Chr17:34036462-34039958 (-)
AKR/J MGP_AKRJ_G0023539
protein coding gene Chr17:34511047-34514530 (-)
BALB/cJ MGP_BALBcJ_G0023577
protein coding gene Chr17:34172745-34176221 (-)
C3H/HeJ MGP_C3HHeJ_G0023338
protein coding gene Chr17:34903830-34907311 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024016
protein coding gene Chr17:36539453-36542944 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021497
protein coding gene Chr17:31803459-31806898 (-)
CAST/EiJ MGP_CASTEiJ_G0022835
protein coding gene Chr17:34906477-34909958 (-)
CBA/J MGP_CBAJ_G0023316
protein coding gene Chr17:38046653-38050129 (-)
DBA/2J MGP_DBA2J_G0023444
protein coding gene Chr17:33357121-33360599 (-)
FVB/NJ MGP_FVBNJ_G0023411
protein coding gene Chr17:33193316-33198198 (-)
LP/J MGP_LPJ_G0023521
protein coding gene Chr17:35528199-35531688 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023433
protein coding gene Chr17:36983834-36987325 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024061
protein coding gene Chr17:34730238-34733718 (-)
PWK/PhJ MGP_PWKPhJ_G0022582
protein coding gene Chr17:32190178-32193780 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022402
protein coding gene Chr17:32740454-32743933 (-)
WSB/EiJ MGP_WSBEiJ_G0022898
protein coding gene Chr17:34849298-34852767 (-)



Homology
more
  • Human Ortholog
    MPIG6B, megakaryocyte and platelet inhibitory receptor G6b
  • Vertebrate Orthologs
    6
  • Human Ortholog
    MPIG6B, megakaryocyte and platelet inhibitory receptor G6b
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C6orf25, G6b, G6b-B, NG31, THAMY
  • Links
    NCBI Gene ID: 80739
    neXtProt AC: NX_O95866
    UniProt: O95866

  • Chr Location
    6p21.33; chr6:31720557-31726710 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit macrothrombocytopenic, increased platelet turnover, enlarged spleen, extramedullary hematopoiesis, myelofibrosis, increased bleeding time, and impaired stimulated platelet adhesion, aggregation and ATP sectretion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000073414 Ensembl Gene Model | MGI Sequence Detail 3492 C57BL/6J ±  kb
transcript ENSMUST00000174190 Ensembl | MGI Sequence Detail 729 Not Applicable  
polypeptide ENSMUSP00000133377 Ensembl | MGI Sequence Detail 242 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
References
more
  • Summaries
    All 31
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:236757 West DB, et al., Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. PLoS Genet. 2016 Feb;12(2):e1005691

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory