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Safb Gene Detail
Summary
  • Symbol
    Safb
  • Name
    scaffold attachment factor B
  • Synonyms
    3110021E02Rik, 5330423C17Rik, SAFB1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146974
    NCBI Gene: 224903
  • Gene Overview
    MyGene.info: SAFB
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56584830-56606294 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.40 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146974
protein coding gene Chr17:56584825-56606294 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023929
protein coding gene Chr17:58288078-58309424 (+)
A/J MGP_AJ_G0023887
protein coding gene Chr17:56695581-56717317 (+)
AKR/J MGP_AKRJ_G0023856
protein coding gene Chr17:57394857-57415926 (+)
BALB/cJ MGP_BALBcJ_G0023888
protein coding gene Chr17:56513004-56535391 (+)
C3H/HeJ MGP_C3HHeJ_G0023652
protein coding gene Chr17:58127211-58149380 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024334
protein coding gene Chr17:60546140-60567686 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021780
protein coding gene Chr17:53170183-53191935 (+)
CAST/EiJ MGP_CASTEiJ_G0023134
protein coding gene Chr17:58406012-58427785 (+)
CBA/J MGP_CBAJ_G0023628
protein coding gene Chr17:62918949-62941733 (+)
DBA/2J MGP_DBA2J_G0023756
protein coding gene Chr17:55396190-55417820 (+)
FVB/NJ MGP_FVBNJ_G0023722
protein coding gene Chr17:54934699-54955746 (+)
LP/J MGP_LPJ_G0023838
protein coding gene Chr17:58974701-58997508 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023750
protein coding gene Chr17:62407165-62432906 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024378
protein coding gene Chr17:57756258-57780207 (+)
PWK/PhJ MGP_PWKPhJ_G0022880
protein coding gene Chr17:54753902-54778334 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022691
protein coding gene Chr17:54526231-54547280 (+)
WSB/EiJ MGP_WSBEiJ_G0023200
protein coding gene Chr17:58362332-58391175 (+)



Homology
more
  • Human Ortholog
    SAFB, scaffold attachment factor B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SAFB, scaffold attachment factor B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HAP, HET, SAB-B1, SAF-B, SAFB1, SAF-B1
  • Links
    NCBI Gene ID: 6294
    neXtProt AC: NX_Q15424
    UniProt: Q15424

  • Chr Location
    19p13.3; chr19:5623035-5668478 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display partial embryonic and neonatal lethality, neonatal cyanosis, impaired embryonic hematopoiesis, male sterility, azoospermia, reduced female fertility, impaired transport of embryos through the oviduct, reduced embryonic growth, testicular degeneration and ovarian atrophy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 224903 NCBI Gene Model | MGI Sequence Detail 21465 C57BL/6J ±  kb
    transcript NM_001163300 RefSeq | MGI Sequence Detail 3183 C57BL/6  
    polypeptide D3YXK2 UniProt | EBI | MGI Sequence Detail 937 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR003034 SAP domain
      IPR036361 SAP domain superfamily
      IPR034781 Scaffold attachment factor B1
    Molecular
    Reagents
    less
    • All nucleic 127
      cDNA 121
      Primer pair 5
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1920397, MGI:1925522, MGI:2147152
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 8
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:261596 Schilders K, et al., Generation of a biotinylatable Sox2 mouse model to identify Sox2 complexes in vivo. Transgenic Res. 2018 Feb;27(1):75-85

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory