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Trip10
Gene Detail
Symbol

Name
ID
Trip10
thyroid hormone receptor interactor 10
MGI:2146901
Synonyms
Cip4
Feature Type
protein coding gene
Genetic Map
Chromosome 17
29.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:57249451-57263697 bp, + strand
From Ensembl annotation of GRCm38

  14247 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:99728  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: TRIP10
Gene Tree: Trip10

Human
homologs
TRIP10, thyroid hormone receptor interactor 10
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9322
neXtProt AC: NX_Q15642

Human Synonyms: CIP4, HSTP, STOT, STP, TRIP-10

Human Chr (Location): 19p13.3; chr19:6739682-6751526 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased insulin-stimulated glucose uptake in adipocytes and decreased circulating glucose levels. Mice homozygous for another knock-out allele exhibit impaired integrin-dependent T-cell trafficking.
 
Interactions
Trip10 interacts with 145 markers (Mir7-1, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process endocytosis, hyperosmotic salinity response
Component cell projection, cytoplasm, ...
Function identical protein binding, lipid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (78)    Tissues (25)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 69
Western blot 9
cDNA source data(63)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(63) cDNA(63)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000019487 (Evidence)
Entrez Gene 106628 (Evidence)
UniGene 37368
DFCI TC1626753, TC1595067, TC1578096
DoTS DT.488595, DT.99849048
NIA Mouse Gene Index U018149
Consensus CDS Project CCDS28930.1
International Mouse Phenotyping Consortium Status Trip10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019487 Ensembl Gene Model | MGI Sequence Detail 14247 C57BL/6J ±  kb
transcript ENSMUST00000019631 Ensembl | MGI Sequence Detail 2290 Not Applicable 
polypeptide ENSMUSP00000019631 Ensembl | MGI Sequence Detail 547 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(12) UniProt(1)
Polymorphisms
SNPs within 2kb(54 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001060 FCH domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000016670 cdc42-interacting protein 4
References
(Earliest) J:77381 Wang L, et al., Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms. Biochem Biophys Res Commun. 2002 May 24;293(5):1426-30
(Latest) J:202363 Chen Y, et al., Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling. Blood. 2013 Sep 5;122(10):1695-706
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory