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Safb2 Gene Detail
Summary
  • Symbol
    Safb2
  • Name
    scaffold attachment factor B2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146808
    NCBI Gene: 224902
  • Gene Overview
    MyGene.info: SAFB2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56560965-56584585 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.39 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146808
protein coding gene Chr17:56560965-56584672 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023928
protein coding gene Chr17:58263741-58287849 (-)
A/J MGP_AJ_G0023886
protein coding gene Chr17:56671451-56695322 (-)
AKR/J MGP_AKRJ_G0023855
protein coding gene Chr17:57370497-57394599 (-)
BALB/cJ MGP_BALBcJ_G0023887
protein coding gene Chr17:56488525-56512143 (-)
C3H/HeJ MGP_C3HHeJ_G0023651
protein coding gene Chr17:58093950-58125932 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024333
protein coding gene Chr17:60520392-60545851 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021779
protein coding gene Chr17:53146067-53169955 (-)
CAST/EiJ MGP_CASTEiJ_G0023133
protein coding gene Chr17:58381913-58405852 (-)
CBA/J MGP_CBAJ_G0023627
protein coding gene Chr17:62891190-62915391 (-)
DBA/2J MGP_DBA2J_G0023755
protein coding gene Chr17:55371495-55395835 (-)
FVB/NJ MGP_FVBNJ_G0023721
protein coding gene Chr17:54908551-54934471 (-)
LP/J MGP_LPJ_G0023837
protein coding gene Chr17:58949695-58974439 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023749
protein coding gene Chr17:62375180-62405356 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024377
protein coding gene Chr17:57729377-57754915 (-)
PWK/PhJ MGP_PWKPhJ_G0022879
protein coding gene Chr17:54728960-54753614 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022690
protein coding gene Chr17:54499009-54526005 (-)
WSB/EiJ MGP_WSBEiJ_G0023199
protein coding gene Chr17:58338373-58362099 (-)



Homology
more
  • Human Ortholog
    SAFB2, scaffold attachment factor B2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SAFB2, scaffold attachment factor B2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 9667
    neXtProt AC: NX_Q14151
    UniProt: Q14151

  • Chr Location
    19p13.3; chr19:5586993-5622927 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male homozyous mutant mice exhibit an increase in testis weight and an increased number of Sertoli cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042625 Ensembl Gene Model | MGI Sequence Detail 23621 C57BL/6J ±  kb
    transcript ENSMUST00000075510 Ensembl | MGI Sequence Detail 3277 Not Applicable  
    polypeptide ENSMUSP00000074953 Ensembl | MGI Sequence Detail 991 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 19

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:3035169
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
    • Latest
      J:225512 Jiang S, et al., Scaffold attachment factor B2 (SAFB2)-null mice reveal non-redundant functions of SAFB2 compared with its paralog, SAFB1. Dis Model Mech. 2015 Sep 1;8(9):1121-7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory