Hrg
Gene Detail

Symbol Name ID

Hrg histidine-rich glycoprotein MGI:2146636

Synonyms

D16JH2, D18020

Feature Type

protein coding gene

Genetic Map

Chromosome 16

13.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:22951072-22961656 bp, + strand From VEGA annotation of GRCm38   10585 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:30973  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Hrg

Human homologs

Human Homolog		HRG, histidine-rich glycoprotein
NCBI Gene ID		3273
neXtProt AC		NX_P04196
Human Synonyms		HPRG, HRGP, THPH11
Human Chr (Location)		3q27; chr3:186383798-186396023 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HRG

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a null mutation display mild monocytosis, decreased bleeding time, faster clot lysis, and abnormal blood coagulation; however, wound healing is normal.

 

Gene Ontology (GO) classifications

All GO classifications: (47 annotations)

Process	angiogenesis, blood coagulation, ...
Component	extracellular region
Function	cell surface binding, cysteine-type endopeptidase inhibitor activity, ...

External Resources: FuncBase

Expression

cDNA source data(117)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(117) cDNA(117)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000033775 (Evidence)
Ensembl Gene Model	ENSMUSG00000022877 (Evidence)
Entrez Gene	94175 (Evidence)
UniGene	358794
DFCI	TC1577747
DoTS	DT.532452, DT.94370114
NIA Mouse Gene Index	U016953
Consensus CDS Project	CCDS49800.1
International Mouse Knockout Project Status	Hrg

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033775	VEGA Gene Model | MGI Sequence Detail	10585	C57BL/6J
transcript	OTTMUST00000085097	VEGA | MGI Sequence Detail	1734	Not Applicable
polypeptide	OTTMUSP00000045931	VEGA | MGI Sequence Detail	536	Not Applicable

All sequences(25) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(75 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000010	Proteinase inhibitor I25, cystatin
Protein Ontology	PR:000008751	histidine-rich glycoprotein

References

(Earliest) J:71004 Hulett MD, et al., Murine histidine-rich glycoprotein: cloning, characterization and cellular origin. Immunol Cell Biol. 2000 Jun;78(3):280-7
(Latest) J:189632 Hale JS, et al., Context dependent role of the CD36--thrombospondin--histidine-rich glycoprotein axis in tumor angiogenesis and growth. PLoS One. 2012;7(7):e40033
All references(35)

Other accession IDs

MGI:2146400