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Hrg
Gene Detail
Symbol

Name
ID
Hrg
histidine-rich glycoprotein
MGI:2146636
Synonyms
D16JH2, D18020
Feature Type
protein coding gene
Genetic Map
Chromosome 16
13.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:22951072-22961656 bp, + strand
From VEGA annotation of GRCm38

  10585 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137650  Vertebrate Homology Class
1 mouse; 1 rat

HCOP human homology predictions: HRG
Gene Tree: Hrg

Human
homologs
HRG, histidine-rich glycoprotein
Orthology source: HGNC

IDs:
NCBI Gene ID: 3273
neXtProt AC: NX_P04196

Human Synonyms: HPRG, HRGP, THPH11

Human Chr (Location): 3q27; chr3:186665958-186678235 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HRG

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display mild monocytosis, decreased bleeding time, faster clot lysis, and abnormal blood coagulation; however, wound healing is normal.
 
Interactions
Hrg interacts with 24 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process angiogenesis, blood coagulation, ...
Component endolysosome, extracellular region, ...
Function cysteine-type endopeptidase inhibitor activity, heparin binding, ...
External Resources: FuncBase
Expression
cDNA source data(117)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hrg    NEW 
Molecular
reagents
All nucleic(117) cDNA(117)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000033775 (Evidence)
Ensembl Gene Model ENSMUSG00000022877 (Evidence)
Entrez Gene 94175 (Evidence)
UniGene 358794
DFCI TC1577747
DoTS DT.532452, DT.94370114
NIA Mouse Gene Index U016953
Consensus CDS Project CCDS49800.1
International Mouse Phenotyping Consortium Status Hrg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033775 VEGA Gene Model | MGI Sequence Detail 10585 C57BL/6J ±  kb
transcript OTTMUST00000085097 VEGA | MGI Sequence Detail 1734 Not Applicable 
polypeptide OTTMUSP00000045931 VEGA | MGI Sequence Detail 536 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(133 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000010 Proteinase inhibitor I25, cystatin
Protein Ontology PR:000008751 histidine-rich glycoprotein
References
(Earliest) J:71004 Hulett MD, et al., Murine histidine-rich glycoprotein: cloning, characterization and cellular origin. Immunol Cell Biol. 2000 Jun;78(3):280-7
(Latest) J:222032 Vu TT, et al., Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein. Blood. 2015 Apr 23;125(17):2712-9
All references(38)
Other
accession IDs
MGI:2146400

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory