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Hrg Gene Detail
Summary
  • Symbol
    Hrg
  • Name
    histidine-rich glycoprotein
  • Synonyms
    D16JH2, D18020
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146636
    NCBI Gene: 94175
  • Gene Overview
    MyGene.info: HRG
Location & Maps
more
  • Sequence Map
    Chr16:22951072-22961656 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10585 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 13.79 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HRG, histidine rich glycoprotein
  • Vertebrate Orthologs
    2
  • Human Ortholog
    HRG, histidine rich glycoprotein
    Orthology source: HGNC
  • Synonyms
    HPRG, HRGP, THPH11
  • Links
    NCBI Gene ID: 3273
    neXtProt AC: NX_P04196

  • Chr Location
    3q27; chr3:186665958-186678235 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human HRG associations

Human Disease Mouse Models
       Thrombophilia Due to Histidine-Rich Glycoprotein Deficiency; THPH11   OMIM: 613116
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display mild monocytosis, decreased bleeding time, faster clot lysis, and abnormal blood coagulation; however, wound healing is normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033775 VEGA Gene Model | MGI Sequence Detail 10585 C57BL/6J ±  kb
transcript OTTMUST00000085097 VEGA | MGI Sequence Detail 1734 Not Applicable  
polypeptide OTTMUSP00000045931 VEGA | MGI Sequence Detail 536 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    133 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR000010 Cystatin domain
Molecular
Reagents
less
  • All nucleic 117
    cDNA 117

    Microarray probesets 2
Other
Accession IDs
less
MGI:2146400
References
more
  • Summaries
    All 34
    Gene Ontology 9
    Phenotypes 11
  • Earliest
    J:71004 Hulett MD, et al., Murine histidine-rich glycoprotein: cloning, characterization and cellular origin. Immunol Cell Biol. 2000 Jun;78(3):280-7
  • Latest
    J:222032 Vu TT, et al., Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein. Blood. 2015 Apr 23;125(17):2712-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory