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Slc51a
Gene Detail
Symbol

Name
ID
Slc51a
solute carrier family 51, alpha subunit
MGI:2146634
Synonyms
D630035O19Rik, Osta, OSTalpha
Feature Type
protein coding gene
Genetic Map
Chromosome 16
22.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:32475522-32487879 bp, - strand
From VEGA annotation of GRCm38

  12358 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:44941  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: SLC51A
Gene Tree: Slc51a

Human
homologs
SLC51A, solute carrier family 51, alpha subunit
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 200931
neXtProt AC: NX_Q86UW1

Human Synonyms: OSTA, OSTalpha

Human Chr (Location): 3q29; chr3:196216512-196233430 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene exhibit growth retardation. In addition, one mutant exhibits impaired intestinal bile acid transport.
 
Interactions
Slc51a interacts with 39 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process bile acid and bile salt transport, transport
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function protein binding, protein heterodimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (10)    Tissues (1)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 10
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc51a    NEW 
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000025790 (Evidence)
Ensembl Gene Model ENSMUSG00000035699 (Evidence)
Entrez Gene 106407 (Evidence)
DFCI TC1582847
NIA Mouse Gene Index U036978
Consensus CDS Project CCDS28121.1
International Mouse Phenotyping Consortium Status Slc51a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025790 VEGA Gene Model | MGI Sequence Detail 12358 C57BL/6J ±  kb
transcript OTTMUST00000063516 VEGA | MGI Sequence Detail 1600 Not Applicable 
polypeptide OTTMUSP00000031404 VEGA | MGI Sequence Detail 340 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(70 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005178 Organic solute transporter Ost-alpha
Protein Ontology PR:000012064 organic solute transporter subunit alpha
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:210898 Wheeler SG, et al., Ostalpha-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity. Am J Physiol Gastrointest Liver Physiol. 2014 Mar 1;306(5):G425-38
All references(36)
Other
accession IDs
MGI:2146587

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory