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Slc51a Gene Detail
Summary
  • Symbol
    Slc51a
  • Name
    solute carrier family 51, alpha subunit
  • Synonyms
    D630035O19Rik, Osta, OSTalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146634
    NCBI Gene: 106407
  • Gene Overview
    MyGene.info: SLC51A
Location & Maps
more
  • Sequence Map
    Chr16:32475522-32487879 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12358 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 22.70 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC51A, solute carrier family 51 alpha subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC51A, solute carrier family 51 alpha subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OSTA, OSTalpha
  • Links
    NCBI Gene ID: 200931
    neXtProt AC: NX_Q86UW1

  • Chr Location
    3q29; chr3:196216512-196233430 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    6
  • Targeted
    4
  • Incidental Mutations
    APF
Mice homozygous for disruptions in this gene exhibit growth retardation. In addition, one mutant exhibits impaired intestinal bile acid transport.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025790 VEGA Gene Model | MGI Sequence Detail 12358 C57BL/6J ±  kb
transcript OTTMUST00000063516 VEGA | MGI Sequence Detail 1600 Not Applicable  
polypeptide OTTMUSP00000031404 VEGA | MGI Sequence Detail 340 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    67 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000012064 organic solute transporter subunit alpha
  • InterPro Domains
    IPR005178 Organic solute transporter subunit alpha/Transmembrane protein 184
Molecular
Reagents
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  • All nucleic 7
    cDNA 7

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146587
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:229058 Hammond CL, et al., Ostalpha-/- mice are not protected from western diet-induced weight gain. Physiol Rep. 2015 Jan 1;3(1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory