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Slc51a Gene Detail
Summary
  • Symbol
    Slc51a
  • Name
    solute carrier family 51, alpha subunit
  • Synonyms
    D630035O19Rik, Osta, OSTalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146634
    NCBI Gene: 106407
  • Gene Overview
    MyGene.info: SLC51A
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:32475578-32487879 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 22.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    66 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146634
protein coding gene Chr16:32475522-32487879 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022740
protein coding gene Chr16:30557530-30574564 (-)
A/J MGP_AJ_G0022705
protein coding gene Chr16:29107169-29119805 (-)
AKR/J MGP_AKRJ_G0022678
protein coding gene Chr16:30168313-30182480 (-)
BALB/cJ MGP_BALBcJ_G0022707
protein coding gene Chr16:29256458-29269850 (-)
C3H/HeJ MGP_C3HHeJ_G0022472
protein coding gene Chr16:30296275-30308974 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023156
protein coding gene Chr16:31207260-31220936 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020674
protein coding gene Chr16:29482968-29495348 (-)
CAST/EiJ MGP_CASTEiJ_G0022000
protein coding gene Chr16:30423871-30439608 (-)
CBA/J MGP_CBAJ_G0022442
protein coding gene Chr16:32451962-32463935 (-)
DBA/2J MGP_DBA2J_G0022575
protein coding gene Chr16:28954571-28968197 (-)
FVB/NJ MGP_FVBNJ_G0022550
protein coding gene Chr16:28945584-28957901 (-)
LP/J MGP_LPJ_G0022642
protein coding gene Chr16:30319087-30332449 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022569
protein coding gene Chr16:31894467-31907850 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023168
protein coding gene Chr16:30152989-30166091 (-)
PWK/PhJ MGP_PWKPhJ_G0021739
protein coding gene Chr16:29277470-29291261 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021570
protein coding gene Chr16:29950043-29963389 (-)
WSB/EiJ MGP_WSBEiJ_G0022044
protein coding gene Chr16:30099536-30111642 (-)



Homology
more
  • Human Ortholog
    SLC51A, solute carrier family 51 alpha subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC51A, solute carrier family 51 alpha subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OSTA, OSTalpha
  • Links
    NCBI Gene ID: 200931
    neXtProt AC: NX_Q86UW1
    UniProt: Q86UW1

  • Chr Location
    3q29; chr3:196216512-196233430 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene exhibit growth retardation. In addition, one mutant exhibits impaired intestinal bile acid transport.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 106407 NCBI Gene Model | MGI Sequence Detail 12302 C57BL/6J ±  kb
    transcript NM_145932 RefSeq | MGI Sequence Detail 1544 C57BL/6  
    polypeptide Q8R000 UniProt | EBI | MGI Sequence Detail 340 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000012064 organic solute transporter subunit alpha
    • InterPro Domains
      IPR005178 Organic solute transporter subunit alpha/Transmembrane protein 184
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146587
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:246615 Christian WV, et al., Global functions of extracellular, transmembrane and cytoplasmic domains of organic solute transporter beta-subunit. Biochem J. 2017 May 25;474(12):1981-1992

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory