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Slc7a4 Gene Detail
Summary
  • Symbol
    Slc7a4
  • Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 4
  • Synonyms
    MGC:27672
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146512
    NCBI Gene: 224022
  • Gene Overview
    MyGene.info: SLC7A4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17572018-17576893 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 10.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146512
protein coding gene Chr16:17572018-17576998 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022586
protein coding gene Chr16:14731433-14735148 (-)
A/J MGP_AJ_G0022547
protein coding gene Chr16:14002479-14006194 (-)
AKR/J MGP_AKRJ_G0022524
protein coding gene Chr16:14548611-14552326 (-)
BALB/cJ MGP_BALBcJ_G0022550
protein coding gene Chr16:14155005-14158726 (-)
C3H/HeJ MGP_C3HHeJ_G0022317
protein coding gene Chr16:14700987-14704729 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023001
protein coding gene Chr16:14967914-14971656 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020521
protein coding gene Chr16:14069565-14074575 (-)
CAST/EiJ MGP_CASTEiJ_G0021845
protein coding gene Chr16:14601935-14605650 (-)
CBA/J MGP_CBAJ_G0022288
protein coding gene Chr16:15638428-15642170 (-)
DBA/2J MGP_DBA2J_G0022418
protein coding gene Chr16:13920518-13924261 (-)
FVB/NJ MGP_FVBNJ_G0022394
protein coding gene Chr16:13962103-13965846 (-)
LP/J MGP_LPJ_G0022485
protein coding gene Chr16:14492144-14495859 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022415
protein coding gene Chr16:15330957-15334784 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023012
protein coding gene Chr16:14494875-14498590 (-)
PWK/PhJ MGP_PWKPhJ_G0021588
protein coding gene Chr16:14174849-14178591 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021416
protein coding gene Chr16:14470995-14474702 (-)
WSB/EiJ MGP_WSBEiJ_G0021892
protein coding gene Chr16:14487593-14491308 (-)



Homology
more
  • Human Ortholog
    SLC7A4, solute carrier family 7 member 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC7A4, solute carrier family 7 member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAT4, CAT-4, HCAT3, VH
  • Links
    NCBI Gene ID: 6545
    neXtProt AC: NX_O43246
    UniProt: O43246

  • Chr Location
    22q11.21; chr22:21028718-21032558 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 224022 NCBI Gene Model | MGI Sequence Detail 4876 C57BL/6J ±  kb
transcript NM_001359891 RefSeq | MGI Sequence Detail 3573 C57BL/6  
polypeptide Q8BLQ7 UniProt | EBI | MGI Sequence Detail 635 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 34
    Primer pair 3

    Microarray probesets 4
References
more
  • Summaries
    All 25
    Developmental Gene Expression 5
    Gene Ontology 2
    Phenotypes 1
  • Earliest
    J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
  • Latest
    J:230261 Racedo SE, et al., Mouse and human CRKL is dosage sensitive for cardiac outflow tract formation. Am J Hum Genet. 2015 Feb 5;96(2):235-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory