About   Help   FAQ
Vps8 Gene Detail
Summary
  • Symbol
    Vps8
  • Name
    VPS8 CORVET complex subunit
  • Synonyms
    mKIAA0804
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146407
    NCBI Gene: 209018
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:21423118-21644680 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 12.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1180 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146407
protein coding gene Chr16:21423118-21644681 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022659
protein coding gene Chr16:18847750-19072649 (+)
A/J MGP_AJ_G0022621
protein coding gene Chr16:17950107-18171444 (+)
AKR/J MGP_AKRJ_G0022596
protein coding gene Chr16:18699363-18931970 (+)
BALB/cJ MGP_BALBcJ_G0022625
protein coding gene Chr16:18130203-18359339 (+)
C3H/HeJ MGP_C3HHeJ_G0022390
protein coding gene Chr16:18806727-19031863 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023076
protein coding gene Chr16:19228101-19480212 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020594
protein coding gene Chr16:18654634-18867173 (+)
CAST/EiJ MGP_CASTEiJ_G0021920
protein coding gene Chr16:18791457-19017851 (+)
CBA/J MGP_CBAJ_G0022362
protein coding gene Chr16:20062033-20303724 (+)
DBA/2J MGP_DBA2J_G0022494
protein coding gene Chr16:17938922-18157697 (+)
FVB/NJ MGP_FVBNJ_G0022469
protein coding gene Chr16:17910858-18128285 (+)
LP/J MGP_LPJ_G0022561
protein coding gene Chr16:18596290-18825476 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022489
protein coding gene Chr16:19655271-19892737 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023087
protein coding gene Chr16:18639359-18876699 (+)
PWK/PhJ MGP_PWKPhJ_G0021660
protein coding gene Chr16:18156173-18373437 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021490
protein coding gene Chr16:18422126-18652213 (+)
WSB/EiJ MGP_WSBEiJ_G0021963
protein coding gene Chr16:18606571-18841089 (+)



Homology
more
  • Human Ortholog
    VPS8, VPS8 subunit of CORVET complex
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VPS8, VPS8 subunit of CORVET complex
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIAA0804
  • Links
    NCBI Gene ID: 23355
    neXtProt AC: NX_Q8N3P4
    UniProt: Q8N3P4

  • Chr Location
    3q27.2; chr3:184812137-185052614 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 44592
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: VPS8
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033653 Ensembl Gene Model | MGI Sequence Detail 221563 C57BL/6J ±  kb
transcript ENSMUST00000115397 Ensembl | MGI Sequence Detail 5032 Not Applicable  
polypeptide ENSMUSP00000111055 Ensembl | MGI Sequence Detail 1429 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000017348 vacuolar protein sorting-associated protein 8
  • InterPro Domains
    IPR011044 Quinoprotein amine dehydrogenase, beta chain-like
    IPR025941 Vacuolar protein sorting-associated protein 8, central domain
    IPR001680 WD40 repeat
    IPR017986 WD40-repeat-containing domain
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    IPR013083 Zinc finger, RING/FYVE/PHD-type
    IPR001841 Zinc finger, RING-type
Molecular
Reagents
less
  • All nucleic 65
    cDNA 65

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146573
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:222663 Perini ED, et al., Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations. Traffic. 2014 Dec;15(12):1366-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/04/2019
MGI 6.14
The Jackson Laboratory