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Deptor Gene Detail
Summary
  • Symbol
    Deptor
  • Name
    DEP domain containing MTOR-interacting protein
  • Synonyms
    4731402B04Rik, 9130412E02Rik, D15Ertd336e, D15Ertd597e, Depdc6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146322
    NCBI Gene: 97998
  • Gene Overview
    MyGene.info: DEPTOR
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:55112317-55259271 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 21.96 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1243 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146322
protein coding gene Chr15:55112317-55259273 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021854
protein coding gene Chr15:54185248-54334443 (+)
A/J MGP_AJ_G0021814
protein coding gene Chr15:52035634-52187070 (+)
AKR/J MGP_AKRJ_G0021795
protein coding gene Chr15:53519517-53675075 (+)
BALB/cJ MGP_BALBcJ_G0021821
protein coding gene Chr15:52259371-52409009 (+)
C3H/HeJ MGP_C3HHeJ_G0021595
protein coding gene Chr15:53600035-53753117 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022260
protein coding gene Chr15:56288259-56441317 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019797
protein coding gene Chr15:49272323-49417309 (+)
CAST/EiJ MGP_CASTEiJ_G0021112
protein coding gene Chr15:54191366-54347920 (+)
CBA/J MGP_CBAJ_G0021564
protein coding gene Chr15:58268429-58431211 (+)
DBA/2J MGP_DBA2J_G0021688
protein coding gene Chr15:51930381-52078674 (+)
FVB/NJ MGP_FVBNJ_G0021666
protein coding gene Chr15:51051534-51202947 (+)
LP/J MGP_LPJ_G0021758
protein coding gene Chr15:53985345-54138244 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021690
protein coding gene Chr15:63374283-63535317 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022283
protein coding gene Chr15:53860115-54019521 (+)
PWK/PhJ MGP_PWKPhJ_G0020857
protein coding gene Chr15:52005918-52149607 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020694
protein coding gene Chr15:53607598-53764082 (+)
WSB/EiJ MGP_WSBEiJ_G0021167
protein coding gene Chr15:53839616-53989902 (+)



Homology
more
  • Human Ortholog
    DEPTOR, DEP domain containing MTOR interacting protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DEPTOR, DEP domain containing MTOR interacting protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DEP.6, DEPDC6
  • Links
    NCBI Gene ID: 64798
    neXtProt AC: NX_Q8TB45
    UniProt: Q8TB45

  • Chr Location
    8q24.12; chr8:119873655-120056202 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32551
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DEPTOR
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from multigenic genotypes
    23 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022419 Ensembl Gene Model | MGI Sequence Detail 146955 C57BL/6J ±  kb
transcript ENSMUST00000096433 Ensembl | MGI Sequence Detail 8547 Not Applicable  
polypeptide ENSMUSP00000094167 Ensembl | MGI Sequence Detail 409 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000029102 DEP domain-containing mTOR-interacting protein
  • InterPro Domains
    IPR000591 DEP domain
    IPR037589 DEP domain-containing mTOR-interacting protein
    IPR037335 DEP domain-containing mTOR-interacting protein, DEP domain 1
    IPR037336 DEP domain-containing mTOR-interacting protein, DEP domain 2
    IPR001478 PDZ domain
    IPR036034 PDZ superfamily
    IPR036390 Winged helix DNA-binding domain superfamily
    IPR036388 Winged helix-like DNA-binding domain superfamily
Molecular
Reagents
less
  • All nucleic 18
    cDNA 16
    Primer pair 2

    Microarray probesets 9
Other
Accession IDs
less
MGI:1196436, MGI:1289169, MGI:1918827, MGI:1921823
References
more
  • Summaries
    All 54
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 2
    Phenotypes 23
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:262591 Wang Q, et al., Deptor Is a Novel Target of Wnt/beta-Catenin/c-Myc and Contributes to Colorectal Cancer Cell Growth. Cancer Res. 2018 Jun 15;78(12):3163-3175

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory