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Topors Gene Detail
Summary
  • Symbol
    Topors
  • Name
    topoisomerase I binding, arginine/serine-rich
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146189
    NCBI Gene: 106021
  • Gene Overview
    MyGene.info: TOPORS
Location & Maps
more
  • Sequence Map
    Chr4:40259601-40269850 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10250 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 20.24 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TOPORS, TOP1 binding arginine/serine rich protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TOPORS, TOP1 binding arginine/serine rich protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LUN, P53BP3, RP31, TP53BPL
  • Links
    NCBI Gene ID: 10210
    neXtProt AC: NX_Q9NS56

  • Chr Location
    9p21; chr9:32540544-32552628 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TOPORS associations

Human Disease Mouse Models
       Retinitis Pigmentosa 31; RP31   OMIM: 609923
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    25
  • Chemically and radiation induced
    1
  • Gene trapped
    24
  • Genomic Mutations
    1 involving Topors
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006555 VEGA Gene Model | MGI Sequence Detail 10250 C57BL/6J ±  kb
transcript OTTMUST00000014968 VEGA | MGI Sequence Detail 3856 Not Applicable  
polypeptide OTTMUSP00000006918 VEGA | MGI Sequence Detail 1033 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    58 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000016549 E3 ubiquitin-protein ligase Topors
  • EC
  • InterPro Domains
    IPR013083 Zinc finger, RING/FYVE/PHD-type
    IPR001841 Zinc finger, RING-type
    IPR017907 Zinc finger, RING-type, conserved site
Molecular
Reagents
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  • All nucleic 97
    cDNA 97

    Microarray probesets 6
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
  • Latest
    J:189972 Braun KR, et al., Inhibition of PDGF-B induction and cell growth by syndecan-1 involves the ubiquitin and SUMO-1 ligase, Topors. PLoS One. 2012;7(8):e43701

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory