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Topors
Gene Detail
Symbol

Name
ID
Topors
topoisomerase I binding, arginine/serine-rich
MGI:2146189
Feature Type
protein coding gene
Genetic Map
Chromosome 4
20.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:40259601-40269850 bp, - strand
From VEGA annotation of GRCm38

  10250 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4237  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: TOPORS
Gene Tree: Topors

Human
homologs
TOPORS, topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10210
neXtProt AC: NX_Q9NS56

Human Synonyms: LUN, P53BP3, RP31, TP53BPL

Human Chr (Location): 9p21; chr9:32540544-32552628 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TOPORS

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(24)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Topors interacts with 208 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (1)    Tissues (1)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
cDNA source data(97)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase topors ; ZFIN toporsa    NEW 
Molecular
reagents
All nucleic(97) cDNA(97)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000006555 (Evidence)
Ensembl Gene Model ENSMUSG00000036822 (Evidence)
Entrez Gene 106021 (Evidence)
UniGene 251548
DFCI TC1574918
DoTS DT.529460
NIA Mouse Gene Index U024955
EC 6.3.2.-
Consensus CDS Project CCDS38710.1
International Mouse Phenotyping Consortium Status Topors
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006555 VEGA Gene Model | MGI Sequence Detail 10250 C57BL/6J ±  kb
transcript OTTMUST00000014968 VEGA | MGI Sequence Detail 3856 Not Applicable 
polypeptide OTTMUSP00000006918 VEGA | MGI Sequence Detail 1033 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(58 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018957 Zinc finger, C3HC4 RING-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000016549 E3 ubiquitin-protein ligase Topors
References
(Earliest) J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
(Latest) J:189972 Braun KR, et al., Inhibition of PDGF-B induction and cell growth by syndecan-1 involves the ubiquitin and SUMO-1 ligase, Topors. PLoS One. 2012;7(8):e43701
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory