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Topors
Gene Detail
 Symbol
Name
ID
Topors
topoisomerase I binding, arginine/serine-rich
MGI:2146189
Feature Type protein coding gene
Genetic Map
Chromosome 4
20.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:40259601-40269850 bp, - strand
From VEGA annotation of GRCm38

  10250 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4237  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Topors

Human
homologs
Human Homolog TOPORS, topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
NCBI Gene ID 10210
neXtProt AC  NX_Q9NS56
Human Synonyms  LUN, P53BP3, RP31, TP53BPL
Human Chr (Location)  9p21; chr9:32540544-32552628 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TOPORS
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(24)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Topors interacts with 209 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process cellular response to DNA damage stimulus, intrinsic apoptotic signaling pathway in response to DNA damage, ...
Component centriole, ciliary basal body, ...
Function antigen binding, coenzyme F420-0 gamma-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (1)    Tissues (1)    Images (2)
Theiler Stages: 21
Assay TypeResults
Immunohistochemistry 1
cDNA source data(97)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(97) cDNA(97)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000006555 (Evidence)
Ensembl Gene ModelENSMUSG00000036822 (Evidence)
Entrez Gene106021 (Evidence)
UniGene251548
DFCITC1574918
DoTSDT.529460
NIA Mouse Gene IndexU024955
EC6.3.2.-
Consensus CDS ProjectCCDS38710.1
International Mouse Knockout Project StatusTopors
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006555 VEGA Gene Model | MGI Sequence Detail 10250 C57BL/6J ±  kb
transcript OTTMUST00000014968 VEGA | MGI Sequence Detail 3856 Not Applicable 
polypeptide OTTMUSP00000006918 VEGA | MGI Sequence Detail 1033 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(58 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018957 Zinc finger, C3HC4 RING-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000016549 E3 ubiquitin-protein ligase Topors
References (Earliest) J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
(Latest) J:189972 Braun KR, et al., Inhibition of PDGF-B induction and cell growth by syndecan-1 involves the ubiquitin and SUMO-1 ligase, Topors. PLoS One. 2012;7(8):e43701
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory