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Topors Gene Detail
Summary
  • Symbol
    Topors
  • Name
    topoisomerase I binding, arginine/serine-rich
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146189
    NCBI Gene: 106021
  • Gene Overview
    MyGene.info: TOPORS
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:40259606-40269841 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 20.24 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    58 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146189
protein coding gene Chr4:40259601-40269850 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028142
protein coding gene Chr4:38112638-38122887 (-)
A/J MGP_AJ_G0028100
protein coding gene Chr4:36702689-36712939 (-)
AKR/J MGP_AKRJ_G0028063
protein coding gene Chr4:37598183-37608433 (-)
BALB/cJ MGP_BALBcJ_G0028112
protein coding gene Chr4:37005524-37015773 (-)
C3H/HeJ MGP_C3HHeJ_G0027840
protein coding gene Chr4:38168284-38178534 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028553
protein coding gene Chr4:39556070-39566319 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025894
protein coding gene Chr4:34401783-34412183 (-)
CAST/EiJ MGP_CASTEiJ_G0027296
protein coding gene Chr4:37838270-37848499 (-)
CBA/J MGP_CBAJ_G0027812
protein coding gene Chr4:40887854-40898103 (-)
DBA/2J MGP_DBA2J_G0027956
protein coding gene Chr4:36613532-36623780 (-)
FVB/NJ MGP_FVBNJ_G0027923
protein coding gene Chr4:35962416-35972665 (-)
LP/J MGP_LPJ_G0028064
protein coding gene Chr4:38182363-38192612 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027956
protein coding gene Chr4:44254455-44264711 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028612
protein coding gene Chr4:37719894-37730143 (-)
PWK/PhJ MGP_PWKPhJ_G0027014
protein coding gene Chr4:36600616-36610886 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025757
protein coding gene Chr3:3701237-3704120 (+)
WSB/EiJ MGP_WSBEiJ_G0027372
protein coding gene Chr4:37716874-37727145 (-)



Homology
more
  • Human Ortholog
    TOPORS, TOP1 binding arginine/serine rich protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TOPORS, TOP1 binding arginine/serine rich protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LUN, P53BP3, RP31, TP53BPL
  • Links
    NCBI Gene ID: 10210
    neXtProt AC: NX_Q9NS56
    UniProt: Q9NS56

  • Chr Location
    9p21.1; chr9:32540544-32552628 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TOPORS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 106021 NCBI Gene Model | MGI Sequence Detail 10236 C57BL/6J ±  kb
transcript NM_134097 RefSeq | MGI Sequence Detail 3842 Not Specified  
polypeptide Q80Z37 UniProt | EBI | MGI Sequence Detail 1033 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 98
    cDNA 98

    Microarray probesets 6
References
more
  • Summaries
    All 31
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
  • Latest
    J:189972 Braun KR, et al., Inhibition of PDGF-B induction and cell growth by syndecan-1 involves the ubiquitin and SUMO-1 ligase, Topors. PLoS One. 2012;7(8):e43701

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory