Topors
Gene Detail

Symbol Name ID

Topors topoisomerase I binding, arginine/serine-rich MGI:2146189

Feature Type

protein coding gene

Genetic Map

Chromosome 4

20.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr4:40259601-40269850 bp, - strand From VEGA annotation of GRCm38   10250 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4237  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Topors

Human homologs

Human Homolog		TOPORS, topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
NCBI Gene ID		10210
neXtProt AC		NX_Q9NS56
Human Synonyms		LUN, P53BP3, RP31, TP53BPL
Human Chr (Location)		9p21; chr9:32540542-32552626 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TOPORS

Alleles and phenotypes

All alleles(24) : Gene trapped(24)

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	apoptotic process, intrinsic apoptotic signaling pathway in response to DNA damage, ...
Component	centriole, cilium basal body, ...
Function	antigen binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (1)    Tissues (1)    Images (2)
Theiler Stages: 21

Assay Type	Results
Immunohistochemistry	1

cDNA source data(97)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(97) cDNA(97)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000006555 (Evidence)
Ensembl Gene Model	ENSMUSG00000036822 (Evidence)
Entrez Gene	106021 (Evidence)
UniGene	251548
DFCI	TC1574918
DoTS	DT.529460
NIA Mouse Gene Index	U024955
EC	6.3.2.-
Consensus CDS Project	CCDS38710.1
International Mouse Knockout Project Status	Topors

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006555	VEGA Gene Model | MGI Sequence Detail	10250	C57BL/6J
transcript	OTTMUST00000014968	VEGA | MGI Sequence Detail	3856	Not Applicable
polypeptide	OTTMUSP00000006918	VEGA | MGI Sequence Detail	1033	Not Applicable

All sequences(30) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(52 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
InterPro	IPR017907	Zinc finger, RING-type, conserved site
Protein Ontology	PR:000016549	E3 ubiquitin-protein ligase Topors

References

(Earliest) J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
(Latest) J:189972 Braun KR, et al., Inhibition of PDGF-B induction and cell growth by syndecan-1 involves the ubiquitin and SUMO-1 ligase, Topors. PLoS One. 2012;7(8):e43701
All references(35)