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Alg10b
Gene Detail
Symbol

Name
ID
Alg10b
asparagine-linked glycosylation 10B (alpha-1,2-glucosyltransferase)
MGI:2146159
Synonyms
Deaf1, LOC380959, nse5
Feature Type
protein coding gene
Genetic Map
Chromosome 15
45.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:90224311-90230554 bp, + strand
From NCBI annotation of GRCm38

  6244 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6030  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ALG10, ALG10B
Protein SuperFamily: alpha-1,2 glucosyltransferase ALG10
Gene Tree: Alg10b

Human
homologs
ALG10, ALG10, alpha-1,2-glucosyltransferase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 84920
neXtProt AC: NX_Q5BKT4

Human Synonyms: ALG10A, DIE2, KCR1

Human Chr (Location): 12p11.1; chr12:34022281-34028302 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ALG10

  1 More Homolog(s):
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Radiation induced(1) Targeted(3)
Genomic Mutations involving Alg10b (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU induced allele exhibit deafness associated with cochlear outer hair cell degeneration.
 
Phenotype Images(2)
Interactions
Alg10b interacts with 248 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000075470 (Evidence)
Entrez Gene 380959 (Evidence)
DFCI TC1646938, TC1580667
DoTS DT.97365806, DT.488970, DT.40147846, DT.101376586, DT.101358778
NIA Mouse Gene Index U016571
EC 2.4.1.256
Consensus CDS Project CCDS27757.1
International Mouse Phenotyping Consortium Status Alg10b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 380959 NCBI Gene Model | MGI Sequence Detail 6244 C57BL/6J ±  kb
transcript NM_001033441 RefSeq | MGI Sequence Detail 3727 C57BL/6 
polypeptide Q3UGP8 UniProt | EBI | MGI Sequence Detail 474 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(61 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016900 Alpha-1, 2 glucosyltransferase Alg10
Protein Ontology PR:000031895 Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase B
Graphical View of Protein Domain Structure
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:209766 Probst FJ, et al., A point mutation in the gene for asparagine-linked glycosylation 10B (Alg10b) causes nonsyndromic hearing impairment in mice (Mus musculus). PLoS One. 2013;8(11):e80408
All references(30)
Other
accession IDs
MGI:2146197, MGI:2146311, MGI:2671653, MGI:2685763, MGI:3035095

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory