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Espl1
Gene Detail
Symbol

Name
ID
Espl1
extra spindle pole bodies 1 (S. cerevisiae)
MGI:2146156
Synonyms
Cerp, ESP1, PRCE, PRCE, separase, SSE
Feature Type
protein coding gene
Genetic Map
Chromosome 15
57.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:102296293-102324356 bp, + strand
From Ensembl annotation of GRCm38

  28064 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32151  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Espl1

Human
homologs
Human Homolog ESPL1, extra spindle pole bodies homolog 1 (S. cerevisiae)
NCBI Gene ID 9700
neXtProt AC  NX_Q14674
Human Synonyms  ESP1, SEPA
Human Chr (Location)  12q; chr12:53268293-53293643 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(7) Radiation induced(1) Targeted(9)
Genomic Mutations involving Espl1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality before somite formation. Conditional null mice display abnormal mitosis during liver regeneration.
 
Interactions
Espl1 interacts with 85 markers (Mir10a, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process chromosome segregation, homologous chromosome segregation, ...
Component centrosome, cytoplasm, ...
Function cysteine-type peptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (103)    Tissues (102)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 103
cDNA source data(114)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(116) cDNA(114) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000058290 (Evidence)
Entrez Gene105988 (Evidence)
UniGene288324
DFCITC1574950
DoTSDT.40149483, DT.101712023
NIA Mouse Gene IndexU043482
EC3.4.22.49
Consensus CDS ProjectCCDS27878.1
International Mouse Knockout Project StatusEspl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058290 Ensembl Gene Model | MGI Sequence Detail 28064 C57BL/6J ±  kb
transcript ENSMUST00000064924 Ensembl | MGI Sequence Detail 6630 Not Applicable 
polypeptide ENSMUSP00000064465 Ensembl | MGI Sequence Detail 2118 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(8) UniProt(7)
Polymorphisms
SNPs within 2kb(107 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005314 Peptidase C50, separase
Protein Ontology PR:000007201 separin
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:205429 Tedeschi A, et al., Wapl is an essential regulator of chromatin structure and chromosome segregation. Nature. 2013 Sep 26;501(7468):564-8
All references(55)
Other
accession IDs
MGI:2146119, MGI:2159408

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory