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Espl1
Gene Detail
Symbol

Name
ID
Espl1
extra spindle pole bodies 1, separase
MGI:2146156
Synonyms
Cerp, ESP1, PRCE, PRCE, separase, SSE
Feature Type
protein coding gene
Genetic Map
Chromosome 15
57.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:102296293-102324356 bp, + strand
From Ensembl annotation of GRCm38

  28064 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32151  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ESPL1
Gene Tree: Espl1

Human
homologs
ESPL1, extra spindle pole bodies like 1, separase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9700
neXtProt AC: NX_Q14674

Human Synonyms: ESP1, SEPA

Human Chr (Location): 12q; chr12:53268266-53293643 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(7) Radiation induced(1) Targeted(9) Transgenic(1)
Genomic Mutations involving Espl1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display embryonic lethality before somite formation. Conditional null mice display abnormal mitosis during liver regeneration.
 
Human Diseases Modeled in Mice Using Espl1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Espl1 interacts with 85 markers (Mir10a, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process chromosome segregation, homologous chromosome segregation, ...
Component centrosome, cytoplasm, ...
Function cysteine-type endopeptidase activity, cysteine-type peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (103)    Tissues (102)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 103
cDNA source data(114)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase espl1    NEW 
Molecular
reagents
All nucleic(116) cDNA(114) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000058290 (Evidence)
Entrez Gene 105988 (Evidence)
UniGene 288324
DFCI TC1574950
DoTS DT.101712023, DT.40149483
NIA Mouse Gene Index U043482
EC 3.4.22.49
Consensus CDS Project CCDS27878.1
International Mouse Phenotyping Consortium Status Espl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058290 Ensembl Gene Model | MGI Sequence Detail 28064 C57BL/6J ±  kb
transcript ENSMUST00000064924 Ensembl | MGI Sequence Detail 6630 Not Applicable 
polypeptide ENSMUSP00000064465 Ensembl | MGI Sequence Detail 2118 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(12) UniProt(4)
Polymorphisms
SNPs within 2kb(107 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005314 Peptidase C50, separase
Protein Ontology PR:000007201 separin
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:205429 Tedeschi A, et al., Wapl is an essential regulator of chromatin structure and chromosome segregation. Nature. 2013 Sep 26;501(7468):564-8
All references(54)
Disease annotation references (1)
Other
accession IDs
MGI:2146119, MGI:2159408

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory