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Egflam
Gene Detail
Symbol

Name
ID
Egflam
EGF-like, fibronectin type III and laminin G domains
MGI:2146149
Synonyms
nectican, pikachurin
Feature Type
protein coding gene
Genetic Map
Chromosome 15
3.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:7206120-7398395 bp, - strand
From VEGA annotation of GRCm38

  192276 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:65044  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: EGFLAM
Gene Tree: Egflam

Human
homologs
EGFLAM, EGF-like, fibronectin type III and laminin G domains
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 133584
neXtProt AC: NX_Q63HQ2

Human Synonyms: AGRINL, AGRNL, PIKA

Human Chr (Location): 5p13.2-p13.1; chr5:38258409-38465480 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(3) Transposon induced(1)
Genomic Mutations involving Egflam (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mutants are viable and fertile under normal conditions. They exhibit abnormal photoreceptor ribbon synapses, resulting in alteration in synaptic signal transmission and visual function.
 
Interactions
Egflam interacts with 364 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (5)    Tissues (5)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
cDNA source data(43)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase egflam    NEW 
Molecular
reagents
All nucleic(43) cDNA(43)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000029264 (Evidence)
Ensembl Gene Model ENSMUSG00000042961 (Evidence)
Entrez Gene 268780 (Evidence)
UniGene 203208
DFCI TC1577708, TC1595295
DoTS DT.524479, DT.91316411, DT.91442997, DT.97359338
NIA Mouse Gene Index U035988
Consensus CDS Project CCDS27370.1, CCDS79359.1
International Mouse Phenotyping Consortium Status Egflam
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029264 VEGA Gene Model | MGI Sequence Detail 192276 C57BL/6J ±  kb
transcript OTTMUST00000072508 VEGA | MGI Sequence Detail 4391 Not Applicable 
polypeptide OTTMUSP00000037355 VEGA | MGI Sequence Detail 1017 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(12) UniProt(2)
Polymorphisms
SNPs within 2kb(898 from dbSNP Build 137)    SNPs within 2kb including multiple locations(908)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase domain
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 EGF-like domain
InterPro IPR003961 Fibronectin type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR001791 Laminin G domain
Protein Ontology PR:000006932 pikachurin
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:184863 Omori Y, et al., Presynaptic dystroglycan-pikachurin complex regulates the proper synaptic connection between retinal photoreceptor and bipolar cells. J Neurosci. 2012 May 2;32(18):6126-37
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory