Egflam MGI Mouse Gene Detail - MGI:2146149 - EGF-like, fibronectin type III and laminin G domains

Symbol

Egflam
Name

EGF-like, fibronectin type III and laminin G domains
Synonyms

nectican, pikachurin

Feature Type

protein coding gene
IDs

MGI:2146149
NCBI Gene: 268780
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr15:7235601-7427876 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 3.50 cM
Mapping Data

1 experiment

SNPs within 2kb

10661 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2146149	protein coding gene	Chr15:7235598-7428203 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021701	protein coding gene	Chr15:4220388-4410257 (-)
A/J	MGP_AJ_G0021662	protein coding gene	Chr15:4127101-4314786 (-)
AKR/J	MGP_AKRJ_G0021640	protein coding gene	Chr15:4149435-4333701 (-)
BALB/cJ	MGP_BALBcJ_G0021669	protein coding gene	Chr15:4036238-4220092 (-)
C3H/HeJ	MGP_C3HHeJ_G0021445	protein coding gene	Chr15:4180707-4374268 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022108	protein coding gene	Chr15:4382020-4574398 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019645	protein coding gene	Chr15:3747215-3924988 (-)
CAST/EiJ	MGP_CASTEiJ_G0020961	protein coding gene	Chr15:4160183-4346735 (-)
CBA/J	MGP_CBAJ_G0021414	protein coding gene	Chr15:4458753-4668601 (-)
DBA/2J	MGP_DBA2J_G0021538	protein coding gene	Chr15:4046298-4241235 (-)
FVB/NJ	MGP_FVBNJ_G0021516	protein coding gene	Chr15:3975395-4167237 (-)
LP/J	MGP_LPJ_G0021606	protein coding gene	Chr15:4143180-4334744 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021541	protein coding gene	Chr15:4650126-4846143 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022131	protein coding gene	Chr15:4180621-4371435 (-)
PWK/PhJ	MGP_PWKPhJ_G0020704	protein coding gene	Chr15:4066387-4249278 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020542	protein coding gene	Chr15:4078510-4266150 (-)
WSB/EiJ	MGP_WSBEiJ_G0021017	protein coding gene	Chr15:4116877-4307801 (-)

Human Ortholog

EGFLAM, EGF like, fibronectin type III and laminin G domains

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EGFLAM, EGF like, fibronectin type III and laminin G domains
Synonyms

AGRINL, AGRNL, PIKA
Links

HGNC:26810

NCBI Gene ID: 133584

UniProt: Q63HQ2
Chr Location

5p13.2-p13.1; chr5:38258409-38465480 (+) GRCh38

MGI Vertebrate Homology

Egflam stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: EGFLAM
Gene Tree

Egflam

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

3
Transposon induced

1
Genomic Mutations

1 involving Egflam
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

60 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutants are viable and fertile under normal conditions. They exhibit abnormal photoreceptor ribbon synapses, resulting in alteration in synaptic signal transmission and visual function.

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All GO Annotations

18
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

5
cDNA Data

44
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase egflam

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All Sequences

79
RefSeq

33
UniProt

2
CCDS

CCDS27370.1, CCDS79359.1

Ensembl

ENSMUSG00000042961 (Evidence)
NCBI Gene

268780

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042961	Ensembl Gene Model \| MGI Sequence Detail	192276	C57BL/6J	± kb
transcript	ENSMUST00000096494	Ensembl \| MGI Sequence Detail	4391	Not Applicable
polypeptide	ENSMUSP00000094238	Ensembl \| MGI Sequence Detail	1017	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006932 pikachurin

(term hierarchy)
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR001881 EGF-like calcium-binding domain

IPR000742 EGF-like domain

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR001791 Laminin G domain

IPR050372 Neurexin-related cell adhesion and synaptic protein
GlyGen

Q4VBE4 2 sites

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All nucleic 44

cDNA 44

Microarray probesets 3

Summaries

All 37

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 9
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:340669 Choi JS, et al., Single-nucleus RNA sequencing of developing superior colliculus identifies neuronal diversity and candidate mediators of circuit assembly. Cell Rep. 2023 Aug 24;42(9):113037

TSS for Egflam:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133645	Chr15:7428175-7428209 (-)	-316 bp
Tssr133644	Chr15:7427894-7427901 (-)	-22 bp
Tssr133643	Chr15:7427867-7427881 (-)	2 bp
Tssr133642	Chr15:7427815-7427828 (-)	54 bp
Tssr133641	Chr15:7427714-7427804 (-)	117 bp
Tssr133640	Chr15:7427584-7427596 (-)	286 bp
Tssr133639	Chr15:7274447-7274468 (-)	153,418 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24