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Egflam
Gene Detail
 Symbol
Name
ID
Egflam
EGF-like, fibronectin type III and laminin G domains
MGI:2146149
Synonyms nectican, pikachurin
Feature Type protein coding gene
Genetic Map
Chromosome 15
3.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:7206120-7398395 bp, - strand
From VEGA annotation of GRCm38

  192276 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:65044  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Egflam

Human
homologs
Human Homolog EGFLAM, EGF-like, fibronectin type III and laminin G domains
NCBI Gene ID 133584
neXtProt AC  NX_Q63HQ2
Human Synonyms  AGRINL, AGRNL, PIKA
Human Chr (Location)  5p13.2-p13.1; chr5:38258409-38465480 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(3) Transposon induced(1)
Genomic Mutations involving Egflam (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants are viable and fertile under normal conditions. They exhibit abnormal photoreceptor ribbon synapses, resulting in alteration in synaptic signal transmission and visual function.
 
Interactions
Egflam interacts with 364 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process extracellular matrix organization, peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan, ...
Component basement membrane, cell junction, ...
Function glycosaminoglycan binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (5)    Tissues (5)    Images (4)
Theiler Stages: 24
Assay TypeResults
Immunohistochemistry 5
cDNA source data(43)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) cDNA(43)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000029264 (Evidence)
Ensembl Gene ModelENSMUSG00000042961 (Evidence)
Entrez Gene268780 (Evidence)
UniGene203208
DFCITC1577708, TC1595295
DoTSDT.524479, DT.91316411, DT.91442997, DT.97359338
NIA Mouse Gene IndexU035988
Consensus CDS ProjectCCDS27370.1
International Mouse Knockout Project StatusEgflam
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029264 VEGA Gene Model | MGI Sequence Detail 192276 C57BL/6J ±  kb
transcript OTTMUST00000072508 VEGA | MGI Sequence Detail 4391 Not Applicable 
polypeptide OTTMUSP00000037355 VEGA | MGI Sequence Detail 1017 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(10) UniProt(2)
Polymorphisms SNPs within 2kb(898 from dbSNP Build 137)    SNPs within 2kb including multiple locations(908)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR001791 Laminin G domain
Protein Ontology PR:000006932 pikachurin
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:184863 Omori Y, et al., Presynaptic dystroglycan-pikachurin complex regulates the proper synaptic connection between retinal photoreceptor and bipolar cells. J Neurosci. 2012 May 2;32(18):6126-37
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory