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Gsdmc2 Gene Detail
Summary
  • Symbol
    Gsdmc2
  • Name
    gasdermin C2
Location &
Maps
more
  • Sequence Map
    Chr15:63696195-63717026 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 27.91 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    232 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146102
 protein coding gene Chr15:63696177-63717042 (-)
129S1/SvImJ ENSMUSG00200027270
 protein coding gene Chr15:60729027-60749866 (-)
A/J ENSMUSG00195005901
 protein coding gene Chr15:60752610-60773398 (-)
AKR/J ENSMUSG00220020239
 protein coding gene Chr15:60669070-60689838 (-)
BALB/cJ ENSMUSG00180008639
 protein coding gene Chr15:60661750-60682547 (-)
C3H/HeJ ENSMUSG00175004397
 protein coding gene Chr15:60953175-60973976 (-)
C57BL/6NJ ENSMUSG00215011010
 protein coding gene Chr15:60679908-60700745 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019836
 protein coding gene Chr15:57735598-57762533 (-)
CAST/EiJ ENSTCUG00005006890
 protein coding gene Chr15:60542205-60563285 (-)
CBA/J ENSMUSG00210007011
 protein coding gene Chr15:60784826-60805629 (-)
DBA/2J ENSMUSG00185025580
 protein coding gene Chr15:60720100-60740940 (-)
FVB/NJ ENSMUSG00205006334
 protein coding gene Chr15:60478977-60499775 (-)
JF1/MsJ ENSUMUG00000024234
 protein coding gene Chr15:60491963-60512895 (-)
LP/J ENSMUSG00230024279
 protein coding gene Chr15:64055740-64076578 (-)
NOD/ShiLtJ ENSMUSG00190015789
 protein coding gene Chr15:60768457-60789290 (-)
NZO/HlLtJ ENSMUSG00225026969
 protein coding gene Chr15:64338301-64359136 (-)
PWK/PhJ ENSLUMG00010027391
 protein coding gene Chr15:60802588-60823512 (-)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005005802
 protein coding gene Chr15:60778711-60799532 (-)



Homology
more
  • Human Ortholog
    GSDMC, gasdermin C
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSDMC, gasdermin C
  • Synonyms
    MLZE
  • Links
    NCBI Gene ID: 56169
    UniProt: Q9BYG8

  • Chr Location
    8q24.21; chr8:129705435-129786624 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    108
  • cDNA Data
    6
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056293 Ensembl Gene Model | MGI Sequence Detail 20832 C57BL/6J ±  kb
transcript ENSMUST00000089900 Ensembl | MGI Sequence Detail 1981 Not Applicable  
polypeptide ENSMUSP00000087344 Ensembl | MGI Sequence Detail 480 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 4
References
more
  • Summaries
    All 53
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 6
    Phenotypes 27
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory