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Agxt2 Gene Detail
Summary
  • Symbol
    Agxt2
  • Name
    alanine-glyoxylate aminotransferase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146052
    NCBI Gene: 268782
  • Gene Overview
    MyGene.info: AGXT2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:10358532-10410153 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51622 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 5.35 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    AGXT2, alanine--glyoxylate aminotransferase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AGXT2, alanine--glyoxylate aminotransferase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AGT2, BAIBA, DAIBAT
  • Links
    NCBI Gene ID: 64902
    neXtProt AC: NX_Q9BYV1
    UniProt: Q9BYV1

  • Chr Location
    5p13.2; chr5:34998101-35048188 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit reduced circulating L-citrulline, hypertension under terminal aesthesia and increased vasodilation maximal response following acetylcholine treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000024223 VEGA Gene Model | MGI Sequence Detail 51622 C57BL/6J ±  kb
    transcript OTTMUST00000058473 VEGA | MGI Sequence Detail 2198 Not Applicable  
    polypeptide OTTMUSP00000028330 VEGA | MGI Sequence Detail 513 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      152 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • EC
    • InterPro Domains
      IPR005814 Aminotransferase class-III
      IPR015424 Pyridoxal phosphate-dependent transferase
      IPR015422 Pyridoxal phosphate-dependent transferase domain 1
      IPR015421 Pyridoxal phosphate-dependent transferase, major domain
    Molecular
    Reagents
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    • All nucleic 21
      cDNA 20
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145968
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 3
    • Earliest
      J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
    • Latest
      J:253755 Burdin DV, et al., Diabetes-linked transcription factor HNF4alpha regulates metabolism of endogenous methylarginines and beta-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2. Sci Rep. 2016 Oct 18;6:35503

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory