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Mtbp Gene Detail
Summary
  • Symbol
    Mtbp
  • Name
    Mdm2, transformed 3T3 cell double minute p53 binding protein
  • Synonyms
    MDM2BP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146005
    NCBI Gene: 105837
Location & Maps
more
  • Sequence Map
    Chr15:55557408-55626423 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      69016 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 22.05 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MTBP, MDM2 binding protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MTBP, MDM2 binding protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MDM2BP
  • Links
    NCBI Gene ID: 27085
    neXtProt AC: NX_Q96DY7

  • Chr Location
    8q24.12; chr8:120445398-120523635 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 11102
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MTBP
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    3
  • Gene trapped
    10
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    4 involving Mtbp
  • Incidental Mutations
Mice homozygous for a reporter allele exhibit early embryonic lethality; interestingly, heterozygous mice are not tumor prone.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035624 VEGA Gene Model | MGI Sequence Detail 69016 C57BL/6J ±  kb
transcript OTTMUST00000091168 VEGA | MGI Sequence Detail 3144 Not Applicable  
polypeptide OTTMUSP00000050180 VEGA | MGI Sequence Detail 894 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    309 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010711 mdm2-binding protein
  • InterPro Domains
    IPR029420 MDM2-binding protein, central domain
    IPR029421 MDM2-binding protein, N-terminal domain
    IPR029418 MDN2-binding protein, C-terminal domain
Molecular
Reagents
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  • All nucleic 55
    cDNA 54
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 36
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 4
    Phenotypes 20
  • Earliest
    J:83418 Boyd MT, et al., A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2. J Biol Chem. 2000 Oct 13;275(41):31883-90
  • Latest
    J:184521 Koss M, et al., Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory