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Scrib Gene Detail
Summary
  • Symbol
    Scrib
  • Name
    scribbled planar cell polarity
  • Synonyms
    Crc, mKIAA0147, Scrb1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145950
    NCBI Gene: 105782
  • Gene Overview
    MyGene.info: SCRIB
Location & Maps
more
  • Sequence Map
    Chr15:76047158-76069784 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22627 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 35.29 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SCRIB, scribbled planar cell polarity protein
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SCRIB, scribbled planar cell polarity protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CRIB1, SCRB1, SCRIB1, Vartul
  • Links
    NCBI Gene ID: 23513
    neXtProt AC: NX_Q14160

  • Chr Location
    8q24.3; chr8:143790920-143815379 (-)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 9 alleles in 13 genetic backgrounds
    24 phenotypes from multigenic genotypes
    4 images
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    24
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    3
  • Gene trapped
    6
  • Radiation induced
    2
  • Spontaneous
    2
  • Targeted
    9
  • Genomic Mutations
    5 involving Scrib
  • Incidental Mutations
Mice homozygous for a null allele display partial prenatal lethality. Mice homozygous for spontaneous or induced alleles exhibit craniofacial or neural tube defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021033 VEGA Gene Model | MGI Sequence Detail 22627 C57BL/6J ±  kb
transcript OTTMUST00000049728 VEGA | MGI Sequence Detail 5599 Not Applicable  
polypeptide OTTMUSP00000023091 VEGA | MGI Sequence Detail 1665 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    73 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 149
    cDNA 146
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGI:1859564
References
more
  • Summaries
    All 82
    Developmental Gene Expression 25
    Diseases 5
    Gene Ontology 15
    Phenotypes 54
  • Earliest
    J:62635 Rachel RA, et al., Retinal axon misrouting at the optic chiasm in mice with neural tube closure defects. Genesis. 2000 May;27(1):32-47
  • Latest
    J:229529 Gibbs BC, et al., Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects. Biol Open. 2016;5(3):323-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory