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Scrib Gene Detail
Summary
  • Symbol
    Scrib
  • Name
    scribbled planar cell polarity
  • Synonyms
    Crc, mKIAA0147, Scrb1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145950
    NCBI Gene: 105782
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:75919011-75941633 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 35.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    73 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145950
 protein coding gene Chr15:75919007-75941633 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021973
 protein coding gene Chr15:76099220-76121846 (-)
A/J MGP_AJ_G0021931
 protein coding gene Chr15:73331160-73353786 (-)
AKR/J MGP_AKRJ_G0021914
 protein coding gene Chr15:75317784-75340410 (-)
BALB/cJ MGP_BALBcJ_G0021940
 protein coding gene Chr15:73349941-73372502 (-)
C3H/HeJ MGP_C3HHeJ_G0021712
 protein coding gene Chr15:75372651-75395277 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022380
 protein coding gene Chr15:78939379-78962005 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019909
 protein coding gene Chr15:70000483-70020327 (-)
CAST/EiJ MGP_CASTEiJ_G0021231
 protein coding gene Chr15:76158284-76180875 (-)
CBA/J MGP_CBAJ_G0021679
 protein coding gene Chr15:81454654-81477280 (-)
DBA/2J MGP_DBA2J_G0021804
 protein coding gene Chr15:72860491-72883117 (-)
FVB/NJ MGP_FVBNJ_G0021785
 protein coding gene Chr15:71912708-71935334 (-)
LP/J MGP_LPJ_G0021875
 protein coding gene Chr15:76191977-76214603 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021809
 protein coding gene Chr15:86756422-86779046 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022400
 protein coding gene Chr15:75566302-75588928 (-)
PWK/PhJ MGP_PWKPhJ_G0020972
 protein coding gene Chr15:73008041-73030742 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020811
 protein coding gene Chr15:75286455-75309053 (-)
WSB/EiJ MGP_WSBEiJ_G0021283
 protein coding gene Chr15:75650280-75672904 (-)



Homology
more
  • Human Ortholog
    SCRIB, scribble planar cell polarity protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCRIB, scribble planar cell polarity protein
  • Synonyms
    CRIB1, oSCRIB, SCRB1, SCRIB1, Vartul
  • Links
    NCBI Gene ID: 23513
    neXtProt AC: NX_Q14160
    UniProt: C0HLS1, Q14160

  • Chr Location
    8q24.3; chr8:143790920-143815379 (-)  GRCh38.p7
Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    63 phenotypes from 10 alleles in 14 genetic backgrounds
    24 phenotypes from multigenic genotypes
    5 images
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display partial prenatal lethality. Mice homozygous for spontaneous or induced alleles exhibit craniofacial or neural tube defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    90
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    42
  • cDNA Data
    147
  • Literature Summary
    53
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 105782 NCBI Gene Model | MGI Sequence Detail 22623 C57BL/6J ±  kb
    transcript NM_134089 RefSeq | MGI Sequence Detail 5645 Not Specified  
    polypeptide Q80U72 UniProt | EBI | MGI Sequence Detail 1612 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 151
      cDNA 147
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1859564
    References
    more
    • Summaries
      All 158
      Developmental Gene Expression 53
      Diseases 4
      Gene Ontology 18
      Phenotypes 77
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:327196 Zhang Z, et al., CDC42 controlled apical-basal polarity regulates intestinal stem cell to transit amplifying cell fate transition via YAP-EGF-mTOR signaling. Cell Rep. 2022 Jan 11;38(2):110009
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/26/2022
    MGI 6.22     		The Jackson Laboratory