Scrib MGI Mouse Gene Detail - MGI:2145950 - scribbled planar cell polarity

Scrib Gene Detail

Symbol

Scrib
Name

scribbled planar cell polarity
Synonyms

Crc, mKIAA0147, Scrb1

Feature Type

protein coding gene
IDs

MGI:2145950
NCBI Gene: 105782
Gene Overview

MyGene.info: SCRIB

Sequence Map

Chr15:76047158-76069784 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

22627 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 35.29 cM
Mapping Data

2 experiments

Human Ortholog

SCRIB, scribbled planar cell polarity protein

Vertebrate Orthologs

8

Human Ortholog

SCRIB, scribbled planar cell polarity protein
Orthology source: HomoloGene, HGNC
Synonyms

CRIB1, SCRB1, SCRIB1, Vartul
Links

HGNC:30377

NCBI Gene ID: 23513

neXtProt AC: NX_Q14160
Chr Location

8q24.3; chr8:143790920-143815379 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 44228
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: SCRIB
Gene Tree

Scrib

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Mutations/Alleles

2 with disease annotations

References

5 with disease annotations

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Phenotype Summary

51 phenotypes from 9 alleles in 13 genetic backgrounds
24 phenotypes from multigenic genotypes
4 images
56 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Chemically induced (ENU)

2
Chemically induced (other)

3
Gene trapped

6
Radiation induced

2
Spontaneous

2
Targeted

9
Genomic Mutations

5 involving Scrib
Incidental Mutations

Mutagenetix , APF , CvDC

Mice homozygous for a null allele display partial prenatal lethality. Mice homozygous for spontaneous or induced alleles exhibit craniofacial or neural tube defects.

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All GO Annotations

54
GO References

15

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

64
Tissues

39
cDNA Data

146
Literature Summary

25

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

GEISHA SCRIB

Xenbase scrib

ZFIN scrib

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Scrib interacts with 78 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

65
RefSeq

19
UniProt

5
CCDS

CCDS27560.1, CCDS79381.1, CCDS79382.1
UniGene

25568

			Length	Strain/Species	Flank
genomic	OTTMUSG00000021033	VEGA Gene Model \| MGI Sequence Detail	22627	C57BL/6J	± kb
transcript	OTTMUST00000049728	VEGA \| MGI Sequence Detail	5599	Not Applicable
polypeptide	OTTMUSP00000023091	VEGA \| MGI Sequence Detail	1665	Not Applicable

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SNPs within 2kb

73 from dbSNP Build 142

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UniProt

5 Sequences
Protein Ontology

PR:000014537 protein LAP4
InterPro Domains

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain, L domain-like

IPR003591 Leucine-rich repeat, typical subtype

IPR001478 PDZ domain

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All nucleic 149

cDNA 146

Primer pair 3

Microarray probesets 4

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MGI:1859564

Summaries

All 82

Developmental Gene Expression 25

Diseases 5

Gene Ontology 15

Phenotypes 56
Earliest

J:62635 Rachel RA, et al., Retinal axon misrouting at the optic chiasm in mice with neural tube closure defects. Genesis. 2000 May;27(1):32-47
Latest

J:229529 Gibbs BC, et al., Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects. Biol Open. 2016;5(3):323-35

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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