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Ano6
Gene Detail
 Symbol
Name
ID
Ano6
anoctamin 6
MGI:2145890
Synonyms 2900059G15Rik, F730003B03Rik, Tmem16f
Feature Type protein coding gene
Genetic Map
Chromosome 15
50.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:95790843-95975464 bp, + strand
From Ensembl annotation of GRCm38

  184622 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:27888  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ano6

Human
homologs
Human Homolog ANO6, anoctamin 6
NCBI Gene ID 196527
neXtProt AC  NX_Q4KMQ2
Human Synonyms  BDPLT7, SCTS, TMEM16F
Human Chr (Location)  12q12; chr12:45215987-45440404 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ANO6
Alleles
and
phenotypes
All alleles(22) : Targeted(4) Gene trapped(18)
 
Mice homozygous for a knock-out allele exhibit impaired platelet coagulation with increased bleeding time. Mice homozygous for a different knock out allele or gene trap exhibit decreased bone mineral deposition and skeletal abnormalities.
 
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process activation of blood coagulation via clotting cascade, blood coagulation, ...
Component chloride channel complex, extracellular vesicular exosome, ...
Function calcium activated cation channel activity, chloride channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (113)    Tissues (101)    Images (30)
Theiler Stages: 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 113
cDNA source data(177)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(177) cDNA(177)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000064210 (Evidence)
Entrez Gene105722 (Evidence)
UniGene38087
DFCITC1575272, TC1622479, TC1624703, TC1639671
DoTSDT.101196571, DT.491093, DT.91295893, DT.97353969
NIA Mouse Gene IndexU016604
Consensus CDS ProjectCCDS37184.1
International Mouse Knockout Project StatusAno6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064210 Ensembl Gene Model | MGI Sequence Detail 184622 C57BL/6J ±  kb
transcript ENSMUST00000071874 Ensembl | MGI Sequence Detail 5640 Not Applicable 
polypeptide ENSMUSP00000071770 Ensembl | MGI Sequence Detail 911 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(16) UniProt(1)
Polymorphisms SNPs within 2kb(2014 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007632 Anoctamin/TMEM 16
Protein Ontology PR:000004061 anoctamin-6
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:198369 Suzuki J, et al., Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. J Biol Chem. 2013 May 10;288(19):13305-16
All references(40)
Other
accession IDs
MGI:1920265, MGI:2146238

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory