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Ano6 Gene Detail
Summary
  • Symbol
    Ano6
  • Name
    anoctamin 6
  • Synonyms
    2900059G15Rik, F730003B03Rik, Tmem16f
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145890
    NCBI Gene: 105722
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:95790843-95974751 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      183909 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 50.66 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ANO6, anoctamin 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ANO6, anoctamin 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BDPLT7, SCTS, TMEM16F
  • Links
    NCBI Gene ID: 196527
    neXtProt AC: NX_Q4KMQ2
    UniProt: Q4KMQ2

  • Chr Location
    12q12; chr12:45215987-45440404 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 27888
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ANO6
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human ANO6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 3 alleles in 4 genetic backgrounds
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired platelet coagulation with increased bleeding time. Mice homozygous for a different knock out allele or gene trap exhibit decreased bone mineral deposition and skeletal abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000064210 Ensembl Gene Model | MGI Sequence Detail 183909 C57BL/6J ±  kb
    transcript ENSMUST00000227791 Ensembl | MGI Sequence Detail 3149 Not Applicable  
    polypeptide ENSMUSP00000153954 Ensembl | MGI Sequence Detail 932 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1992 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 178
      cDNA 178

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1920265, MGI:2146238
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 13
      Phenotypes 37
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:248566 Baig AA, et al., TMEM16F-Mediated Platelet Membrane Phospholipid Scrambling Is Critical for Hemostasis and Thrombosis but not Thromboinflammation in Mice-Brief Report. Arterioscler Thromb Vasc Biol. 2016 Nov;36(11):2152-2157

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory