Ano6
Gene Detail

Symbol Name ID

Ano6 anoctamin 6 MGI:2145890

Synonyms

2900059G15Rik, F730003B03Rik, Tmem16f

Feature Type

protein coding gene

Genetic Map

Chromosome 15

50.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:95790843-95975464 bp, + strand From Ensembl annotation of GRCm38   184622 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:27888  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ano6

Human homologs

Human Homolog		ANO6, anoctamin 6
NCBI Gene ID		196527
neXtProt AC		NX_Q4KMQ2
Human Synonyms		BDPLT7, SCTS, TMEM16F
Human Chr (Location)		12q12; chr12:45609770-45834187 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ANO6

Alleles and phenotypes

All alleles(20) : Targeted(2) Gene trapped(18)
 

Mice homozygous for a knock-out allele exhibit impaired platelet coagulation with increased bleeding time.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	activation of blood coagulation via clotting cascade, blood coagulation, ...
Component	chloride channel complex, integral to membrane, ...
Function	calcium activated cation channel activity, chloride channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (113)    Tissues (101)    Images (30)
Theiler Stages: 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	113

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(14)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000064210 (Evidence)
Entrez Gene	105722 (Evidence)
DFCI	TC1575272, TC1622479, TC1624703, TC1639671
DoTS	DT.101196571, DT.491093, DT.91295893, DT.97353969
NIA Mouse Gene Index	U016604
Consensus CDS Project	CCDS37184.1
International Mouse Knockout Project Status	Ano6

Sequences

Length	Strain/Species
genomic	ENSMUSG00000064210	Ensembl Gene Model | MGI Sequence Detail	184622	C57BL/6J
transcript	ENSMUST00000071874	Ensembl | MGI Sequence Detail	5640	Not Applicable
polypeptide	ENSMUSP00000071770	Ensembl | MGI Sequence Detail	911	Not Applicable

All sequences(34) RefSeq(4) UniProt(1)

Polymorphisms

SNPs(1524 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007632	Anoctamin/TMEM 16
Protein Ontology	PR:000004061	anoctamin-6

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:190271 Duran C, et al., ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins. Am J Physiol Cell Physiol. 2012 Feb 1;302(3):C482-93
All references(35)

Other accession IDs

MGI:1920265, MGI:2146238