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Ano6
Gene Detail
Symbol

Name
ID
Ano6
anoctamin 6
MGI:2145890
Synonyms
2900059G15Rik, F730003B03Rik, Tmem16f
Feature Type
protein coding gene
Genetic Map
Chromosome 15
50.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:95790843-95975464 bp, + strand
From Ensembl annotation of GRCm38

  184622 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:27888  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ANO6
Gene Tree: Ano6

Human
homologs
ANO6, anoctamin 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 196527
neXtProt AC: NX_Q4KMQ2

Human Synonyms: BDPLT7, SCTS, TMEM16F

Human Chr (Location): 12q12; chr12:45215987-45440404 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ANO6

Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(18) Radiation induced(1) Targeted(4)
Genomic Mutations involving Ano6 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit impaired platelet coagulation with increased bleeding time. Mice homozygous for a different knock out allele or gene trap exhibit decreased bone mineral deposition and skeletal abnormalities.
 
Phenotype Images(2)
Interactions
Ano6 interacts with 325 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (67 annotations)
Process activation of blood coagulation via clotting cascade, bleb assembly, ...
Component cell, cell surface, ...
Function calcium activated cation channel activity, chloride channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (113)    Tissues (101)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 113
cDNA source data(177)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ANO6 ; Xenbase ano6    NEW 
Molecular
reagents
All nucleic(177) cDNA(177)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000064210 (Evidence)
Entrez Gene 105722 (Evidence)
UniGene 38087
DFCI TC1624703, TC1622479, TC1575272, TC1639671
DoTS DT.101196571, DT.91295893, DT.491093, DT.97353969
NIA Mouse Gene Index U016604
Consensus CDS Project CCDS37184.1
International Mouse Phenotyping Consortium Status Ano6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000064210 Ensembl Gene Model | MGI Sequence Detail 184622 C57BL/6J ±  kb
transcript ENSMUST00000071874 Ensembl | MGI Sequence Detail 5640 Not Applicable 
polypeptide ENSMUSP00000071770 Ensembl | MGI Sequence Detail 911 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(12) UniProt(1)
Polymorphisms
SNPs within 2kb(2014 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007632 Anoctamin/TMEM 16
Protein Ontology PR:000004061 anoctamin-6
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:220494 Ousingsawat J, et al., Anoctamin-6 controls bone mineralization by activating the calcium transporter NCX1. J Biol Chem. 2015 Mar 6;290(10):6270-80
All references(45)
Other
accession IDs
MGI:1920265, MGI:2146238

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory