Kctd12 MGI Mouse Gene Detail - MGI:2145823 - potassium channel tetramerisation domain containing 12

Symbol

Kctd12
Name

potassium channel tetramerisation domain containing 12
Synonyms

Pfet1, Pfetin

Feature Type

protein coding gene
IDs

MGI:2145823
NCBI Gene: 239217
Gene Overview

MyGene.info: KCTD12
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr14:102976581-102982637 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 51.55 cM
Mapping Data

1 experiment

SNPs within 2kb

9 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145823	protein coding gene	Chr14:102976581-102982637 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021626	protein coding gene	Chr14:99461783-99467843 (-)
A/J	MGP_AJ_G0021584	protein coding gene	Chr14:96180420-96186474 (-)
AKR/J	MGP_AKRJ_G0021560	protein coding gene	Chr14:99057138-99063194 (-)
BALB/cJ	MGP_BALBcJ_G0021590	protein coding gene	Chr14:96527446-96533504 (-)
C3H/HeJ	MGP_C3HHeJ_G0021368	protein coding gene	Chr14:98952603-98958659 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022030	protein coding gene	Chr14:103483392-103489448 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019570	protein coding gene	Chr14:93054035-93060001 (-)
CAST/EiJ	MGP_CASTEiJ_G0020885	protein coding gene	Chr14:96290393-96296396 (-)
CBA/J	MGP_CBAJ_G0021336	protein coding gene	Chr14:107189178-107195232 (-)
DBA/2J	MGP_DBA2J_G0021460	protein coding gene	Chr14:95661814-95667870 (-)
FVB/NJ	MGP_FVBNJ_G0021437	protein coding gene	Chr14:94653497-94659553 (-)
LP/J	MGP_LPJ_G0021528	protein coding gene	Chr14:100279944-100285933 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021464	protein coding gene	Chr14:110044213-110051830 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022053	protein coding gene	Chr14:98569657-98575712 (-)
PWK/PhJ	MGP_PWKPhJ_G0020628	protein coding gene	Chr14:92670627-92676716 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020466	protein coding gene	Chr14:94618278-94624308 (-)
WSB/EiJ	MGP_WSBEiJ_G0020938	protein coding gene	Chr14:99229969-99236053 (-)

Human Ortholog

KCTD12, potassium channel tetramerization domain containing 12

Vertebrate Orthologs

10

Human Ortholog

KCTD12, potassium channel tetramerization domain containing 12
Orthology source: HomoloGene, HGNC
Synonyms

C13orf2, PFET1, PFETIN
Links

HGNC:14678

NCBI Gene ID: 115207

neXtProt AC: NX_Q96CX2

UniProt: Q96CX2
Chr Location

13q22.3; chr13:76880169-76886405 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 16316
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: KCTD12
Gene Tree

Kctd12

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Chemically induced (other)

1
Targeted

1
Genomic Mutations

1 involving Kctd12
Incidental Mutations

CvDC
Find Mice (IMSR)

3 strains or lines available

Mice homozygous for a knock-out allele exhibit increased fear learning of a discrete auditory-conditioned stimulus, increased activity during the inactive (light) phase and increased intrinsic excitability of pyramidal neurons.

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All GO Annotations

11
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

54
Tissues

37
cDNA Data

19
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kctd12

ZFIN kctd12.1, kctd12.2

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Kctd12 interacts with 100 markers (Mir7-2, Mir7b, Mir9-1, ...) View All

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All Sequences

55
RefSeq

2
UniProt

6
CCDS

CCDS70611.1

Ensembl

ENSMUSG00000098557 (Evidence)
NCBI Gene

239217

			Length	Strain/Species	Flank
genomic	239217	NCBI Gene Model \| MGI Sequence Detail	6057	C57BL/6J	± kb
transcript	NM_177715	RefSeq \| MGI Sequence Detail	6076	C57BL/6
polypeptide	Q6WVG3	UniProt \| EBI \| MGI Sequence Detail	327	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000030477 BTB/POZ domain-containing protein KCTD12

(term hierarchy)
InterPro Domains

IPR000210 BTB/POZ domain

IPR003131 Potassium channel tetramerisation-type BTB domain

IPR011333 SKP1/BTB/POZ domain superfamily

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All nucleic 22

cDNA 19

Primer pair 3

Microarray probesets 5

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MGI:2145763

Summaries

All 36

Developmental Gene Expression 7

Gene Ontology 4

Phenotypes 4
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:277380 Telley L, et al., Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex. Science. 2019 May 10;364(6440)

TSS for Kctd12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130063	Chr14:102982695-102982704 (-)	-63 bp
Tssr130061	Chr14:102981458-102981461 (-)	1,177 bp
Tssr130060	Chr14:102980516-102980523 (-)	2,117 bp
Tssr130057	Chr14:102978663-102978675 (-)	3,968 bp
Tssr130056	Chr14:102978558-102978571 (-)	4,072 bp
Tssr130055	Chr14:102978126-102978137 (-)	4,505 bp
Tssr130054	Chr14:102977945-102977971 (-)	4,679 bp
Tssr130053	Chr14:102977857-102977926 (-)	4,745 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/01/2019 MGI 6.14