Kctd12 MGI Mouse Gene Detail - MGI:2145823 - potassium channel tetramerisation domain containing 12

Kctd12 Gene Detail

Symbol

Kctd12
Name

potassium channel tetramerisation domain containing 12
Synonyms

Pfet1, Pfetin

Feature Type

protein coding gene
IDs

MGI:2145823
NCBI Gene: 239217
Gene Overview

MyGene.info: KCTD12

Sequence Map

Chr14:102976581-102982637 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

6057 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 51.55 cM
Mapping Data

1 experiment

Human Ortholog

KCTD12, potassium channel tetramerization domain containing 12

Vertebrate Orthologs

10

Human Ortholog

KCTD12, potassium channel tetramerization domain containing 12
Orthology source: HomoloGene, HGNC
Synonyms

C13orf2, PFET1, PFETIN
Links

HGNC:14678

NCBI Gene ID: 115207

neXtProt AC: NX_Q96CX2
Chr Location

13q22.3; chr13:76880169-76886405 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 16316
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;2 zebrafish;1 frog, western clawed
HCOP

human homology predictions: KCTD12
Gene Tree

Kctd12

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Chemically induced (other)

1
Targeted

1
Genomic Mutations

1 involving Kctd12
Incidental Mutations

CvDC

Mice homozygous for a knock-out allele exhibit increased fear learning of a discrete auditory-conditioned stimulus, increased activity during the inactive (light) phase and increased intrinsic excitability of pyramidal neurons.

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All GO Annotations

12
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

47
Tissues

33
cDNA Data

18
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO
Other Vertebrate Links

Xenbase kctd12

ZFIN kctd12.1, kctd12.2

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Kctd12 interacts with 100 markers (Mir7-2, Mir7b, Mir9-1, ...) View All

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All Sequences

41
RefSeq

2
UniProt

6
CCDS

CCDS70611.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000044960	VEGA Gene Model \| MGI Sequence Detail	6057	C57BL/6J	± kb
transcript	OTTMUST00000118155	VEGA \| MGI Sequence Detail	6057	Not Applicable
polypeptide	OTTMUSP00000065973	VEGA \| MGI Sequence Detail	327	Not Applicable

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SNPs within 2kb

9 from dbSNP Build 142

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UniProt

6 Sequences
InterPro Domains

IPR000210 BTB/POZ domain

IPR003131 Potassium channel tetramerisation-type BTB domain

IPR011333 SKP1/BTB/POZ domain

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All nucleic 22

cDNA 18

Primer pair 3

Other 1

Microarray probesets 5

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MGI:2145763

Summaries

All 29

Developmental Gene Expression 5

Gene Ontology 4

Phenotypes 3
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:227160 Cathomas F, et al., Altered emotionality and neuronal excitability in mice lacking KCTD12, an auxiliary subunit of GABAB receptors associated with mood disorders. Transl Psychiatry. 2015;5:e510

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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