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Ppif
Gene Detail
Symbol

Name
ID
Ppif
peptidylprolyl isomerase F (cyclophilin F)
MGI:2145814
Synonyms
CypD, CyP-D, CyP-F, mitochondrial Cyclophilin D
Feature Type
protein coding gene
Genetic Map
Chromosome 14
15.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:25694154-25700468 bp, + strand
From VEGA annotation of GRCm38

  6315 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38696  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Peptidylpro_ismrse
Gene Tree: Ppif

Human
homologs
Human Homolog PPIF, peptidylprolyl isomerase F
NCBI Gene ID 10105
neXtProt AC  NX_P30405
Human Synonyms  CYP3, CypD, Cyp-D, CyP-M
Human Chr (Location)  10q22-q23; chr10:79347464-79355334 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
 
Homozygous inactivation of this gene results in abnormal mitochondrial physiology and a significantly decreased infarction size following ischemia/reperfusion-induced cardiac or brain injury.
 
Interactions
Ppif interacts with 147 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process apoptotic mitochondrial changes, apoptotic process, ...
Component mitochondrial inner membrane, mitochondrial matrix, ...
Function cyclosporin A binding, isomerase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 2
cDNA source data(75)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(78) cDNA(77) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023363 (Evidence)
Ensembl Gene ModelENSMUSG00000021868 (Evidence)
Entrez Gene105675 (Evidence)
UniGene41656
DFCITC1576928
DoTSDT.94154730, DT.534958
NIA Mouse Gene IndexU015402
EC5.2.1.8
Consensus CDS ProjectCCDS26874.1
International Mouse Knockout Project StatusPpif
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023363 VEGA Gene Model | MGI Sequence Detail 6315 C57BL/6J ±  kb
transcript OTTMUST00000056678 VEGA | MGI Sequence Detail 1549 Not Applicable 
polypeptide OTTMUSP00000027263 VEGA | MGI Sequence Detail 206 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002130 Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain
InterPro IPR024936 Cyclophilin-type peptidyl-prolyl cis-trans isomerase
InterPro IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
Protein Ontology PR:000013080 peptidyl-prolyl cis-trans isomerase F, mitochondrial
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:212155 Alavian KN, et al., An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10580-5
All references(82)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory