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Ppif Gene Detail
Summary
  • Symbol
    Ppif
  • Name
    peptidylprolyl isomerase F (cyclophilin F)
  • Synonyms
    CypD, CyP-D, CyP-F, mitochondrial Cyclophilin D
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145814
    NCBI Gene: 105675
Location & Maps
more
  • Sequence Map
    Chr14:25694154-25700468 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6315 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PPIF, peptidylprolyl isomerase F
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPIF, peptidylprolyl isomerase F
    Orthology source: HomoloGene
  • Synonyms
    CYP3, CypD, Cyp-D, CyP-M
  • Links
    NCBI Gene ID: 10105
    neXtProt AC: NX_P30405

  • Chr Location
    10q22.3; chr10:79347464-79355334 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 5 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Targeted
    8
  • Transgenic
    1
Homozygous inactivation of this gene results in abnormal mitochondrial physiology and a significantly decreased infarction size following ischemia/reperfusion-induced cardiac or brain injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023363 VEGA Gene Model | MGI Sequence Detail 6315 C57BL/6J ±  kb
transcript OTTMUST00000056678 VEGA | MGI Sequence Detail 1549 Not Applicable  
polypeptide OTTMUSP00000027263 VEGA | MGI Sequence Detail 206 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    44 from dbSNP Build 137
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013080 peptidyl-prolyl cis-trans isomerase F, mitochondrial
  • EC
  • InterPro Domains
    IPR029000 Cyclophilin-like domain
    IPR024936 Cyclophilin-type peptidyl-prolyl cis-trans isomerase
    IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
    IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
Molecular
Reagents
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  • All nucleic 78
    cDNA 77
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 85
    Developmental Gene Expression 1
    Gene Ontology 16
    Phenotypes 52
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:223364 Mantel CR, et al., Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock. Cell. 2015 Jun 18;161(7):1553-65

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory