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Ppif Gene Detail
Summary
  • Symbol
    Ppif
  • Name
    peptidylprolyl isomerase F (cyclophilin F)
  • Synonyms
    CypD, CyP-D, CyP-F, mitochondrial Cyclophilin D
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145814
    NCBI Gene: 105675
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:25694578-25700892 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 15.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    44 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145814
 protein coding gene Chr14:25693998-25700892 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021066
 protein coding gene Chr14:18627723-18634039 (+)
A/J MGP_AJ_G0021015
 protein coding gene Chr14:18171595-18177911 (+)
AKR/J MGP_AKRJ_G0020992
 protein coding gene Chr14:18809135-18815451 (+)
BALB/cJ MGP_BALBcJ_G0021018
 protein coding gene Chr14:18272941-18279257 (+)
C3H/HeJ MGP_C3HHeJ_G0020802
 protein coding gene Chr14:18728242-18734558 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021451
 protein coding gene Chr14:19199877-19206191 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019019
 protein coding gene Chr14:18373578-18379960 (+)
CAST/EiJ MGP_CASTEiJ_G0020326
 protein coding gene Chr14:18607704-18614062 (+)
CBA/J MGP_CBAJ_G0020768
 protein coding gene Chr14:20144980-20151296 (+)
DBA/2J MGP_DBA2J_G0020891
 protein coding gene Chr14:17971849-17978163 (+)
FVB/NJ MGP_FVBNJ_G0020874
 protein coding gene Chr14:17851477-17857793 (+)
LP/J MGP_LPJ_G0020967
 protein coding gene Chr14:18903669-18909985 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020900
 protein coding gene Chr14:19833603-19839917 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021484
 protein coding gene Chr14:18607746-18614060 (+)
PWK/PhJ MGP_PWKPhJ_G0020075
 protein coding gene Chr14:17594101-17600565 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019897
 protein coding gene Chr14:18421926-18428261 (+)
WSB/EiJ MGP_WSBEiJ_G0020382
 protein coding gene Chr14:18599147-18605552 (+)



Homology
more
  • Human Ortholog
    PPIF, peptidylprolyl isomerase F
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPIF, peptidylprolyl isomerase F
  • Synonyms
    CYP3, CypD, Cyp-D, CyP-M
  • Links
    NCBI Gene ID: 10105
    neXtProt AC: NX_P30405
    UniProt: P30405

  • Chr Location
    10q22.3; chr10:79347469-79355334 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 5 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    130 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in abnormal mitochondrial physiology and a significantly decreased infarction size following ischemia/reperfusion-induced cardiac or brain injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    68
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    76
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021868 Ensembl Gene Model | MGI Sequence Detail 6315 C57BL/6J ±  kb
transcript ENSMUST00000022419 Ensembl | MGI Sequence Detail 1549 Not Applicable  
polypeptide ENSMUSP00000022419 Ensembl | MGI Sequence Detail 206 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013080 peptidyl-prolyl cis-trans isomerase F, mitochondrial
    (term hierarchy)
  • EC
    5.2.1.8
  • InterPro Domains
    IPR029000 Cyclophilin-like domain superfamily
    IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
    IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
Molecular
Reagents
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  • All nucleic 79
    cDNA 78
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 178
    Developmental Gene Expression 4
    Gene Ontology 18
    Phenotypes 130
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:346863 Stauffer WT, et al., Cyclophilin D knockout significantly prevents HCC development in a streptozotocin-induced mouse model of diabetes-linked NASH. PLoS One. 2024;19(4):e0301711
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory