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Exoc5 Gene Detail
Summary
  • Symbol
    Exoc5
  • Name
    exocyst complex component 5
  • Synonyms
    PRO1912, SEC10, Sec10l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145645
    NCBI Gene: 105504
  • Gene Overview
    MyGene.info: EXOC5
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:49011922-49066667 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 25.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    266 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145645
protein coding gene Chr14:49004090-49066667 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021228
protein coding gene Chr14:42906448-42967388 (-)
A/J MGP_AJ_G0021177
protein coding gene Chr14:41555993-41608456 (-)
AKR/J MGP_AKRJ_G0021155
protein coding gene Chr14:43177940-43232104 (-)
BALB/cJ MGP_BALBcJ_G0021180
protein coding gene Chr14:41604520-41656656 (-)
C3H/HeJ MGP_C3HHeJ_G0020963
protein coding gene Chr14:42958764-43012319 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021615
protein coding gene Chr14:44665209-44725157 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019174
protein coding gene Chr14:40857032-40909876 (-)
CAST/EiJ MGP_CASTEiJ_G0020489
protein coding gene Chr14:40096227-40156312 (-)
CBA/J MGP_CBAJ_G0020930
protein coding gene Chr14:46105372-46163748 (-)
DBA/2J MGP_DBA2J_G0021053
protein coding gene Chr14:41428068-41481171 (-)
FVB/NJ MGP_FVBNJ_G0021038
protein coding gene Chr14:41170526-41225607 (-)
LP/J MGP_LPJ_G0021122
protein coding gene Chr14:43156518-43220852 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021063
protein coding gene Chr14:45403185-45484865 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021648
protein coding gene Chr14:42711081-42764738 (-)
PWK/PhJ MGP_PWKPhJ_G0020237
protein coding gene Chr14:38331190-38386392 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020062
protein coding gene Chr14:38820837-38880531 (-)
WSB/EiJ MGP_WSBEiJ_G0020545
protein coding gene Chr14:42815151-42870134 (-)



Homology
more
  • Human Ortholog
    EXOC5, exocyst complex component 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EXOC5, exocyst complex component 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSEC10, PRO1912, SEC10, SEC10L1, SEC10P
  • Links
    NCBI Gene ID: 10640
    neXtProt AC: NX_O00471
    UniProt: O00471

  • Chr Location
    14q22.3; chr14:57202476-57268899 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in all cells die prior to E8.5. Mice homozygous for a conditional allele activated in kidney cells exhibit ureteropelvic junction obstructions leading to neontal death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 105504 NCBI Gene Model | MGI Sequence Detail 54746 C57BL/6J ±  kb
transcript NM_207214 RefSeq | MGI Sequence Detail 4659 C57BL/6  
polypeptide Q3TPX4 UniProt | EBI | MGI Sequence Detail 708 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR033960 Exocyst complex component EXOC5/Sec10
    IPR009976 Exocyst complex component Sec10-like
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 6
Other
Accession IDs
less
MGI:2145643, MGI:2684922
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Gene Ontology 10
    Phenotypes 12
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:256230 Shin SW, et al., Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice. Nat Commun. 2017 Nov 21;8(1):1643

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory