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Akr1c18 Gene Detail
Summary
  • Symbol
    Akr1c18
  • Name
    aldo-keto reductase family 1, member C18
  • Synonyms
    20alpha-HSD, 20alpha-hydroxysteroid dehydrogenase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145420
    NCBI Gene: 105349
  • Gene Overview
    MyGene.info: AKR1C3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:4132615-4150654 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18040 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 2.31 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    AKR1C3, aldo-keto reductase family 1 member C3
  • Vertebrate Orthologs
    16
  • Human Ortholog
    AKR1C3, aldo-keto reductase family 1 member C3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DD3, DDX, HA1753, HAKRB, HAKRe, hluPGFS, HSD17B5, PGFS
  • Links
    NCBI Gene ID: 8644
    neXtProt AC: NX_P42330
    UniProt: P42330

  • Chr Location
    10p15.1; chr10:5048766-5107686 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for mutations in this gene display prolonged pregnancies and decreased number of pups. Some cannot induce parturition while others are able to give birth but show a prolonged estrous cycle.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000027950 VEGA Gene Model | MGI Sequence Detail 18040 C57BL/6J ±  kb
    transcript OTTMUST00000069234 VEGA | MGI Sequence Detail 1207 Not Applicable  
    polypeptide OTTMUSP00000035133 VEGA | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      107 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 18
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 11
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:82195 Vergnes L, et al., A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13. J Lipid Res. 2003 Mar;44(3):503-11
    • Latest
      J:245934 Xing Y, et al., Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1. Development. 2017 Oct 15;144(20):3798-3807

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory