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Akr1c18 Gene Detail
Summary
  • Symbol
    Akr1c18
  • Name
    aldo-keto reductase family 1, member C18
  • Synonyms
    20alpha-HSD, 20alpha-hydroxysteroid dehydrogenase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145420
    NCBI Gene: 105349
  • Gene Overview
    MyGene.info: AKR1C3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:4132615-4150651 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 2.31 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145420
protein coding gene Chr13:4132615-4150654 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020203
protein coding gene Chr13:617076-634881 (-)
A/J MGP_AJ_G0020159
protein coding gene Chr13:709708-727570 (-)
AKR/J MGP_AKRJ_G0020134
protein coding gene Chr13:730425-748469 (-)
BALB/cJ MGP_BALBcJ_G0020142
protein coding gene Chr13:708095-726102 (-)
C3H/HeJ MGP_C3HHeJ_G0019946
protein coding gene Chr13:794190-812211 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020589
protein coding gene Chr13:687467-705424 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018201
protein coding gene Chr13:613642-631746 (-)
CAST/EiJ MGP_CASTEiJ_G0019486
protein coding gene Chr13:633726-651597 (-)
CBA/J MGP_CBAJ_G0019913
protein coding gene Chr13:700155-718150 (-)
DBA/2J MGP_DBA2J_G0020030
protein coding gene Chr13:627858-645642 (-)
FVB/NJ MGP_FVBNJ_G0020015
protein coding gene Chr13:599280-617302 (-)
LP/J MGP_LPJ_G0020104
protein coding gene Chr13:683350-701272 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020051
protein coding gene Chr13:757644-775306 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020617
protein coding gene Chr13:681534-699444 (-)
PWK/PhJ MGP_PWKPhJ_G0019248
protein coding gene Chr13:691087-709438 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019053
protein coding gene Chr13:724580-742560 (-)
WSB/EiJ MGP_WSBEiJ_G0019544
protein coding gene Chr13:632390-650406 (-)



Homology
more
  • Human Ortholog
    AKR1C3, aldo-keto reductase family 1 member C3
  • Vertebrate Orthologs
    16
  • Human Ortholog
    AKR1C3, aldo-keto reductase family 1 member C3
    Orthology source: HomoloGene
  • Synonyms
    DD3, DDX, HA1753, HAKRB, HAKRe, hluPGFS, HSD17B5, PGFS
  • Links
    NCBI Gene ID: 8644
    neXtProt AC: NX_P42330
    UniProt: P42330

  • Chr Location
    10p15.1; chr10:5048766-5107686 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for mutations in this gene display prolonged pregnancies and decreased number of pups. Some cannot induce parturition while others are able to give birth but show a prolonged estrous cycle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 105349 NCBI Gene Model | MGI Sequence Detail 18037 C57BL/6J ±  kb
    transcript NM_134066 RefSeq | MGI Sequence Detail 1199 C57BL/6  
    polypeptide Q8K023 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 18
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 11
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:82195 Vergnes L, et al., A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13. J Lipid Res. 2003 Mar;44(3):503-11
    • Latest
      J:245934 Xing Y, et al., Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1. Development. 2017 Oct 15;144(20):3798-3807

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory