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Txndc5 Gene Detail
Summary
  • Symbol
    Txndc5
  • Name
    thioredoxin domain containing 5
  • Synonyms
    ERp46, PC-TRP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145316
    NCBI Gene: 105245
  • Gene Overview
    MyGene.info: TXNDC5
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:38684242-38712800 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 18.27 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145316
protein coding gene Chr13:38684055-38712800 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020473
protein coding gene Chr13:36853058-36882409 (-)
A/J MGP_AJ_G0020427
protein coding gene Chr13:35675460-35703568 (-)
AKR/J MGP_AKRJ_G0020405
protein coding gene Chr13:36623657-36651632 (-)
BALB/cJ MGP_BALBcJ_G0020423
protein coding gene Chr13:35777053-35805060 (-)
C3H/HeJ MGP_C3HHeJ_G0020222
protein coding gene Chr13:36452675-36481461 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020856
protein coding gene Chr13:38052476-38080738 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018443
protein coding gene Chr13:33856938-33885382 (-)
CAST/EiJ MGP_CASTEiJ_G0019737
protein coding gene Chr13:36222281-36259226 (-)
CBA/J MGP_CBAJ_G0020183
protein coding gene Chr13:39654234-39685321 (-)
DBA/2J MGP_DBA2J_G0020305
protein coding gene Chr13:35197090-35225378 (-)
FVB/NJ MGP_FVBNJ_G0020284
protein coding gene Chr13:34726234-34754692 (-)
LP/J MGP_LPJ_G0020380
protein coding gene Chr13:37098253-37126920 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020314
protein coding gene Chr13:39746132-39775518 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020899
protein coding gene Chr13:36195606-36223812 (-)
PWK/PhJ MGP_PWKPhJ_G0019492
protein coding gene Chr13:35315977-35351745 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019323
protein coding gene Chr13:34861750-34899734 (-)
WSB/EiJ MGP_WSBEiJ_G0019799
protein coding gene Chr13:36544645-36572874 (-)



Homology
more
  • Human Ortholog
    TXNDC5, thioredoxin domain containing 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TXNDC5, thioredoxin domain containing 5
  • Synonyms
    ENDOPDI, ERP46, HCC2, HCC-2, PDIA15, STRF8, UNQ364
  • Links
    NCBI Gene ID: 81567
    neXtProt AC: NX_Q8NBS9
    UniProt: Q8NBS9

  • Chr Location
    6p24.3; chr6:7881250-7910814 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 105245 NCBI Gene Model | MGI Sequence Detail 28559 C57BL/6J ±  kb
transcript NM_145367 RefSeq | MGI Sequence Detail 2671 C57BL/6  
polypeptide Q91W90 UniProt | EBI | MGI Sequence Detail 417 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    Genomic 1
    cDNA 13

    Microarray probesets 4
References
more
  • Summaries
    All 46
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:295439 Lee TH, et al., Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFbeta signaling through TGFBR1 stabilization. Nat Commun. 2020 Aug 26;11(1):4254

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/15/2021
MGI 6.17
The Jackson Laboratory