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Srek1 Gene Detail
Summary
  • Symbol
    Srek1
  • Name
    splicing regulatory glutamine/lysine-rich protein 1
  • Synonyms
    AL118220, Sfrs12, SRrp508, SRrp86
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145245
    NCBI Gene: 218543
  • Gene Overview
    MyGene.info: SREK1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:103739348-103774608 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 56.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    185 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145245
protein coding gene Chr13:103738565-103774608 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020900
protein coding gene Chr13:105825613-105849676 (-)
A/J MGP_AJ_G0020851
protein coding gene Chr13:101701279-101724114 (-)
AKR/J MGP_AKRJ_G0020826
protein coding gene Chr13:104792214-104815036 (-)
BALB/cJ MGP_BALBcJ_G0020851
protein coding gene Chr13:102404041-102436147 (-)
C3H/HeJ MGP_C3HHeJ_G0020640
protein coding gene Chr13:104538277-104561862 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021285
protein coding gene Chr13:109003302-109028754 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018855
protein coding gene Chr13:97323671-97345575 (-)
CAST/EiJ MGP_CASTEiJ_G0020159
protein coding gene Chr13:103992523-104018248 (-)
CBA/J MGP_CBAJ_G0020602
protein coding gene Chr13:113267817-113293571 (-)
DBA/2J MGP_DBA2J_G0020726
protein coding gene Chr13:101471252-101496464 (-)
FVB/NJ MGP_FVBNJ_G0020708
protein coding gene Chr13:100159253-100182106 (-)
LP/J MGP_LPJ_G0020800
protein coding gene Chr13:105845463-105868422 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020736
protein coding gene Chr13:113415493-113438158 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021324
protein coding gene Chr13:104277527-104302111 (-)
PWK/PhJ MGP_PWKPhJ_G0019912
protein coding gene Chr13:100206104-100228550 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019734
protein coding gene Chr13:100468008-100493015 (-)
WSB/EiJ MGP_WSBEiJ_G0020217
protein coding gene Chr13:104737276-104761009 (-)



Homology
more
  • Human Ortholog
    SREK1, splicing regulatory glutamic acid and lysine rich protein 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SREK1, splicing regulatory glutamic acid and lysine rich protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SFRS12, SRrp508, SRrp86
  • Links
    NCBI Gene ID: 140890
    neXtProt AC: NX_Q8WXA9
    UniProt: Q8WXA9

  • Chr Location
    5q12.3; chr5:66144218-66183616 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032621 Ensembl Gene Model | MGI Sequence Detail 35261 C57BL/6J ±  kb
transcript ENSMUST00000074616 Ensembl | MGI Sequence Detail 3934 Not Applicable  
polypeptide ENSMUSP00000074196 Ensembl | MGI Sequence Detail 610 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000014751 splicing factor, arginine/serine-rich 12
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR035979 RNA-binding domain superfamily
    IPR000504 RNA recognition motif domain
    IPR033568 Splicing regulatory glutamine/lysine-rich protein 1
    IPR034192 SREK1, RNA recognition motif 2
Molecular
Reagents
less
  • All nucleic 20
    cDNA 19
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2145251, MGI:3034554
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory