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Arrdc3
Gene Detail
Symbol

Name
ID
Arrdc3
arrestin domain containing 3
MGI:2145242
Synonyms
mKIAA1376
Feature Type
protein coding gene
Genetic Map
Chromosome 13
41.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:80883384-80896035 bp, + strand
From VEGA annotation of GRCm38

  12652 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69318  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ARRDC3
Gene Tree: Arrdc3

Human
homologs
ARRDC3, arrestin domain containing 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 57561
neXtProt AC: NX_Q96B67

Human Synonyms: TLIMP

Human Chr (Location): 5q14.3; chr5:91368724-91383359 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(21) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit resistance to age-related obesity, insulin resistance, and hepatic steatosis. Mice homozygous for a different gene trap allele exhibit resistance to obesity, embryonic lethality when dams are fed a standard chow and dandruff due to very thin skin.
 
Phenotype Images(1)
Interactions
Arrdc3 interacts with 416 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process fat pad development, negative regulation of heat generation, ...
Component cytoplasm, endosome, ...
Function beta-3 adrenergic receptor binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (17)    Tissues (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 17
cDNA source data(115)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase arrdc3 ; ZFIN arrdc3a, arrdc3b    NEW 
Molecular
reagents
All nucleic(116) cDNA(116)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000034707 (Evidence)
Ensembl Gene Model ENSMUSG00000074794 (Evidence)
Entrez Gene 105171 (Evidence)
UniGene 423137
DFCI TC1582484, TC1598942, TC1597341
DoTS DT.94280262, DT.101293445, DT.91429805, DT.490585
NIA Mouse Gene Index U023610
Consensus CDS Project CCDS36736.1
International Mouse Phenotyping Consortium Status Arrdc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034707 VEGA Gene Model | MGI Sequence Detail 12652 C57BL/6J ±  kb
transcript OTTMUST00000088135 VEGA | MGI Sequence Detail 4088 Not Applicable 
polypeptide OTTMUSP00000048023 VEGA | MGI Sequence Detail 414 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(5) UniProt(4)
Polymorphisms
SNPs within 2kb(23 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011022 Arrestin C-terminal-like domain
InterPro IPR011021 Arrestin-like, N-terminal
InterPro IPR014756 Immunoglobulin E-set
Protein Ontology PR:000032649 arrestin domain-containing protein 3
References
(Earliest) J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
(Latest) J:195551 Shea FF, et al., Mammalian alpha arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with beta arrestins. PLoS One. 2012;7(12):e50557
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory