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Eif2b2
Gene Detail
Symbol

Name
ID
Eif2b2
eukaryotic translation initiation factor 2B, subunit 2 beta
MGI:2145118
Synonyms
EIF2B, EIF-2Bbeta
Feature Type
protein coding gene
Genetic Map
Chromosome 12
39.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:85219481-85226628 bp, + strand
From VEGA annotation of GRCm38

  7148 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6507  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EIF2B2
Gene Tree: Eif2b2

Human
homologs
EIF2B2, eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8892
neXtProt AC: NX_P49770

Human Synonyms: EIF2B, EIF-2Bbeta

Human Chr (Location): 14q24.3; chr14:75002909-75009591 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human EIF2B2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Eif2b2 interacts with 73 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cellular metabolic process, cellular response to stimulus, ...
Component cytoplasm, eukaryotic translation initiation factor 2B complex
Function ATP binding, GTP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (39)    Tissues (26)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 31
RT-PCR 8
cDNA source data(95)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase eif2b2    NEW 
Molecular
reagents
All nucleic(96) cDNA(95) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000030645 (Evidence)
Ensembl Gene Model ENSMUSG00000004788 (Evidence)
Entrez Gene 217715 (Evidence)
UniGene 29041
DFCI TC1572512, TC1775836
DoTS DT.94216341, DT.493601
NIA Mouse Gene Index U014207
Consensus CDS Project CCDS26053.1
International Mouse Phenotyping Consortium Status Eif2b2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030645 VEGA Gene Model | MGI Sequence Detail 7148 C57BL/6J ±  kb
transcript OTTMUST00000075867 VEGA | MGI Sequence Detail 1605 Not Applicable 
polypeptide OTTMUSP00000039844 VEGA | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000649 Initiation factor 2B-related
Protein Ontology PR:000006963 translation initiation factor eIF-2B subunit beta
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:211935 Dorval V, et al., Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models. PLoS One. 2014;9(1):e85510
All references(38)
Other
accession IDs
MGI:2144728

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory