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Eif2b2 Gene Detail
Summary
  • Symbol
    Eif2b2
  • Name
    eukaryotic translation initiation factor 2B, subunit 2 beta
  • Synonyms
    EIF2B, EIF-2Bbeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145118
    NCBI Gene: 217715
  • Gene Overview
    MyGene.info: EIF2B2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:85219481-85226628 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 39.60 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    24 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145118
protein coding gene Chr12:85219481-85226628 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019955
protein coding gene Chr12:85985264-85992403 (+)
A/J MGP_AJ_G0019912
protein coding gene Chr12:82722096-82729243 (+)
AKR/J MGP_AKRJ_G0019888
protein coding gene Chr12:84963872-84971015 (+)
BALB/cJ MGP_BALBcJ_G0019892
protein coding gene Chr12:83067563-83074713 (+)
C3H/HeJ MGP_C3HHeJ_G0019698
protein coding gene Chr12:85437403-85444581 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020343
protein coding gene Chr12:88463646-88470789 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017961
protein coding gene Chr12:79608836-79616570 (+)
CAST/EiJ MGP_CASTEiJ_G0019247
protein coding gene Chr12:80406477-80413692 (+)
CBA/J MGP_CBAJ_G0019669
protein coding gene Chr12:91850287-91857426 (+)
DBA/2J MGP_DBA2J_G0019784
protein coding gene Chr12:82239904-82247043 (+)
FVB/NJ MGP_FVBNJ_G0019770
protein coding gene Chr12:81202090-81209232 (+)
LP/J MGP_LPJ_G0019856
protein coding gene Chr12:85862706-85869842 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019809
protein coding gene Chr12:94728645-94737622 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020377
protein coding gene Chr12:84569767-84576915 (+)
PWK/PhJ MGP_PWKPhJ_G0019011
protein coding gene Chr12:76739226-76746403 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018806
protein coding gene Chr12:79050787-79058041 (+)
WSB/EiJ MGP_WSBEiJ_G0019299
protein coding gene Chr12:85294026-85301265 (+)



Homology
more
  • Human Ortholog
    EIF2B2, eukaryotic translation initiation factor 2B subunit beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EIF2B2, eukaryotic translation initiation factor 2B subunit beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EIF2B, EIF-2Bbeta
  • Links
    NCBI Gene ID: 8892
    neXtProt AC: NX_P49770
    UniProt: P49770

  • Chr Location
    14q24.3; chr14:75002909-75009591 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 6507
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EIF2B2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human EIF2B2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 217715 NCBI Gene Model | MGI Sequence Detail 7148 C57BL/6J ±  kb
transcript NM_145445 RefSeq | MGI Sequence Detail 1605 C57BL/6  
polypeptide Q99LD9 UniProt | EBI | MGI Sequence Detail 351 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 97
    cDNA 96
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144728
References
more
  • Summaries
    All 36
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:211935 Dorval V, et al., Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models. PLoS One. 2014;9(1):e85510

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory