Eif2b2 MGI Mouse Gene Detail - MGI:2145118 - eukaryotic translation initiation factor 2B, subunit 2 beta

Symbol

Eif2b2
Name

eukaryotic translation initiation factor 2B, subunit 2 beta
Synonyms

EIF2B, EIF-2Bbeta

Feature Type

protein coding gene
IDs

MGI:2145118
NCBI Gene: 217715
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr12:85266255-85273402 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 39.60 cM
Mapping Data

1 experiment

SNPs within 2kb

24 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145118	protein coding gene	Chr12:85266255-85273402 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019955	protein coding gene	Chr12:85985264-85992403 (+)
A/J	MGP_AJ_G0019912	protein coding gene	Chr12:82722096-82729243 (+)
AKR/J	MGP_AKRJ_G0019888	protein coding gene	Chr12:84963872-84971015 (+)
BALB/cJ	MGP_BALBcJ_G0019892	protein coding gene	Chr12:83067563-83074713 (+)
C3H/HeJ	MGP_C3HHeJ_G0019698	protein coding gene	Chr12:85437403-85444581 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020343	protein coding gene	Chr12:88463646-88470789 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017961	protein coding gene	Chr12:79608836-79616570 (+)
CAST/EiJ	MGP_CASTEiJ_G0019247	protein coding gene	Chr12:80406477-80413692 (+)
CBA/J	MGP_CBAJ_G0019669	protein coding gene	Chr12:91850287-91857426 (+)
DBA/2J	MGP_DBA2J_G0019784	protein coding gene	Chr12:82239904-82247043 (+)
FVB/NJ	MGP_FVBNJ_G0019770	protein coding gene	Chr12:81202090-81209232 (+)
LP/J	MGP_LPJ_G0019856	protein coding gene	Chr12:85862706-85869842 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019809	protein coding gene	Chr12:94728645-94737622 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020377	protein coding gene	Chr12:84569767-84576915 (+)
PWK/PhJ	MGP_PWKPhJ_G0019011	protein coding gene	Chr12:76739226-76746403 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018806	protein coding gene	Chr12:79050787-79058041 (+)
WSB/EiJ	MGP_WSBEiJ_G0019299	protein coding gene	Chr12:85294026-85301265 (+)

Human Ortholog

EIF2B2, eukaryotic translation initiation factor 2B subunit beta

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EIF2B2, eukaryotic translation initiation factor 2B subunit beta
Synonyms

EIF2B, EIF2Bbeta, EIF-2Bbeta, VWM2
Links

HGNC:3258

NCBI Gene ID: 8892

neXtProt AC: NX_P49770

UniProt: P49770
Chr Location

14q24.3; chr14:75002921-75012366 (+) GRCh38

MGI Vertebrate Homology

Eif2b2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EIF2B2
Gene Tree

Eif2b2

Diseases

2 with human EIF2B2 associations

				Human Disease	Mouse Models
				leukoencephalopathy with vanishing white matter IDs leukoencephalopathy with vanishing white matter DOID:0060868 ICD10CM:E75.2 OMIM:PS603896 ORDO:135 ORDO:157713 ORDO:157716 ORDO:157719
				leukoencephalopathy with vanishing white matter 2 IDs leukoencephalopathy with vanishing white matter 2 DOID:0070373 OMIM:620312

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Targeted

2
Genomic Mutations

1 involving Eif2b2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available

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All GO Annotations

46
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

745
Tissues

26
cDNA Data

96
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eif2b2

ZFIN eif2b2

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All Sequences

53
RefSeq

2
UniProt

4
CCDS

CCDS26053.1

Ensembl

ENSMUSG00000004788 (Evidence)
NCBI Gene

217715

			Length	Strain/Species	Flank
genomic	217715	NCBI Gene Model \| MGI Sequence Detail	7148	C57BL/6J	± kb
transcript	NM_145445	RefSeq \| MGI Sequence Detail	1605	C57BL/6
polypeptide	Q99LD9	UniProt \| EBI \| MGI Sequence Detail	351	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006963 translation initiation factor eIF2B subunit beta

(term hierarchy)
InterPro Domains

IPR042529 Initiation factor 2B-like, C-terminal

IPR000649 Initiation factor 2B-related

IPR037171 NagB/RpiA transferase-like

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All nucleic 97

cDNA 96

Primer pair 1

Microarray probesets 3

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MGI:2144728

Summaries

All 40

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 8
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:274872 Ingham NJ, et al., Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS Biol. 2019 Apr;17(4):e3000194

TSS for Eif2b2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114380	Chr12:85266249-85266320 (+)	30 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23