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Eif2b2
Gene Detail
 Symbol
Name
ID
Eif2b2
eukaryotic translation initiation factor 2B, subunit 2 beta
MGI:2145118
Synonyms EIF2B, EIF-2Bbeta
Feature Type protein coding gene
Genetic Map
Chromosome 12
39.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:85219481-85226628 bp, + strand
From VEGA annotation of GRCm38

  7148 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6507  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Eif2b2

Human
homologs
Human Homolog EIF2B2, eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
NCBI Gene ID 8892
neXtProt AC  NX_P49770
Human Synonyms  EIF2B, EIF-2Bbeta
Human Chr (Location)  14q24.3; chr14:75002909-75009591 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human EIF2B2
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Eif2b2 interacts with 73 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cellular metabolic process, cellular response to stimulus, ...
Component cytoplasm, eukaryotic translation initiation factor 2B complex
Function ATP binding, GTP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (39)    Tissues (26)    Images (8)
Theiler Stages: 2, 3, 4, 5, 23, 28
Assay TypeResults
RNA in situ 31
RT-PCR 8
cDNA source data(95)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(96) cDNA(95) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000030645 (Evidence)
Ensembl Gene ModelENSMUSG00000004788 (Evidence)
Entrez Gene217715 (Evidence)
UniGene29041
DFCITC1572512, TC1775836
DoTSDT.493601, DT.94216341
NIA Mouse Gene IndexU014207
Consensus CDS ProjectCCDS26053.1
International Mouse Knockout Project StatusEif2b2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030645 VEGA Gene Model | MGI Sequence Detail 7148 C57BL/6J ±  kb
transcript OTTMUST00000075867 VEGA | MGI Sequence Detail 1605 Not Applicable 
polypeptide OTTMUSP00000039844 VEGA | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000649 Initiation factor 2B-related
Protein Ontology PR:000006963 translation initiation factor eIF-2B subunit beta
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(38)
Other
accession IDs
MGI:2144728

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory