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Sgsm2 Gene Detail
Summary
  • Symbol
    Sgsm2
  • Name
    small G protein signaling modulator 2
  • Synonyms
    D630003G22Rik, mKIAA0397, Rutbc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144695
    NCBI Gene: 97761
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:74740087-74787886 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.76 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144695
protein coding gene Chr11:74740087-74787929 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018700
protein coding gene Chr11:75566423-75612803 (-)
A/J MGP_AJ_G0018666
protein coding gene Chr11:72764915-72805816 (-)
AKR/J MGP_AKRJ_G0018636
protein coding gene Chr11:74972790-75013798 (-)
BALB/cJ MGP_BALBcJ_G0018640
protein coding gene Chr11:73132804-73174248 (-)
C3H/HeJ MGP_C3HHeJ_G0018453
protein coding gene Chr11:74975283-75018786 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019091
protein coding gene Chr11:77937649-77987635 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016726
protein coding gene Chr11:69790096-69830990 (-)
CAST/EiJ MGP_CASTEiJ_G0018007
protein coding gene Chr11:75351688-75400463 (-)
CBA/J MGP_CBAJ_G0018423
protein coding gene Chr11:81360647-81406930 (-)
DBA/2J MGP_DBA2J_G0018532
protein coding gene Chr11:72363779-72404374 (-)
FVB/NJ MGP_FVBNJ_G0018522
protein coding gene Chr11:71935259-71977638 (-)
LP/J MGP_LPJ_G0018603
protein coding gene Chr11:76162382-76205485 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018548
protein coding gene Chr11:81965314-82011277 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019131
protein coding gene Chr11:75162934-75203760 (-)
PWK/PhJ MGP_PWKPhJ_G0017778
protein coding gene Chr11:73062654-73103942 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017569
protein coding gene Chr11:74732728-74778998 (-)
WSB/EiJ MGP_WSBEiJ_G0018060
protein coding gene Chr11:74969411-75013584 (-)



Homology
more
  • Human Ortholog
    SGSM2, small G protein signaling modulator 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SGSM2, small G protein signaling modulator 2
  • Synonyms
    RUTBC1
  • Links
    NCBI Gene ID: 9905
    neXtProt AC: NX_O43147
    UniProt: O43147

  • Chr Location
    17p13.3; chr17:2337498-2381058 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038351 Ensembl Gene Model | MGI Sequence Detail 47800 C57BL/6J ±  kb
transcript ENSMUST00000081799 Ensembl | MGI Sequence Detail 4873 Not Applicable  
polypeptide ENSMUSP00000080489 Ensembl | MGI Sequence Detail 1050 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 60
    cDNA 58
    Primer pair 2

    Microarray probesets 2
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:230050 Marubashi S, et al., RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes. J Biol Chem. 2016 Jan 15;291(3):1427-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory