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Cnot6 Gene Detail
Summary
  • Symbol
    Cnot6
  • Name
    CCR4-NOT transcription complex, subunit 6
  • Synonyms
    A230103N10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144529
    NCBI Gene: 104625
  • Gene Overview
    MyGene.info: CNOT6
Location & Maps
more
  • Sequence Map
    Chr11:49671503-49712723 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      41221 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CNOT6, CCR4-NOT transcription complex subunit 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CNOT6, CCR4-NOT transcription complex subunit 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CCR4, Ccr4a
  • Links
    NCBI Gene ID: 57472
    neXtProt AC: NX_Q9ULM6

  • Chr Location
    5q35.3; chr5:180494373-180578405 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Chemically induced (other)
    1
  • Gene trapped
    24
  • Targeted
    2
  • Genomic Mutations
    1 involving Cnot6
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005565 VEGA Gene Model | MGI Sequence Detail 41221 C57BL/6J ±  kb
transcript OTTMUST00000012362 VEGA | MGI Sequence Detail 5736 Not Applicable  
polypeptide OTTMUSP00000005724 VEGA | MGI Sequence Detail 557 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    60 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000005653 CCR4-NOT transcription complex subunit 6
  • EC
  • InterPro Domains
    IPR005135 Endonuclease/exonuclease/phosphatase
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
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  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGI:2143972
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 2
    Phenotypes 16
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:198500 Nakahara M, et al., Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Mamm Genome. 2013 Jun;24(5-6):228-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory