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Cnot6
Gene Detail
 Symbol
Name
ID
Cnot6
CCR4-NOT transcription complex, subunit 6
MGI:2144529
Synonyms A230103N10Rik
Feature Type protein coding gene
Genetic Map
Chromosome 11
29.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:49671503-49712723 bp, - strand
From VEGA annotation of GRCm38

  41221 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69187  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Cnot6

Human
homologs
Human Homolog CNOT6, CCR4-NOT transcription complex, subunit 6
NCBI Gene ID 57472
neXtProt AC  NX_Q9ULM6
Human Synonyms  CCR4, Ccr4a
Human Chr (Location)  5q35.3; chr5:180494230-180578358 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(24) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Cnot6 interacts with 441 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay, gene silencing by RNA, ...
Component CCR4-NOT complex, cytoplasm, ...
Function exonuclease activity, exoribonuclease activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (94)    Tissues (94)    Images (16)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000005565 (Evidence)
Ensembl Gene ModelENSMUSG00000020362 (Evidence)
Entrez Gene104625 (Evidence)
DFCITC1576080, TC1597226, TC1598467
DoTSDT.40181066, DT.97377906, DT.99849127
NIA Mouse Gene IndexU032719
EC3.1.13.4
Consensus CDS ProjectCCDS24621.1, CCDS70172.1
International Mouse Knockout Project StatusCnot6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005565 VEGA Gene Model | MGI Sequence Detail 41221 C57BL/6J ±  kb
transcript OTTMUST00000012362 VEGA | MGI Sequence Detail 5736 Not Applicable 
polypeptide OTTMUSP00000005724 VEGA | MGI Sequence Detail 557 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(12) UniProt(2)
Polymorphisms SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005135 Endonuclease/exonuclease/phosphatase
InterPro IPR001611 Leucine-rich repeat
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000005653 CCR4-NOT transcription complex subunit 6
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:198500 Nakahara M, et al., Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Mamm Genome. 2013 Jun;24(5-6):228-39
All references(45)
Other
accession IDs
MGI:2143972

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory