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Alkbh5 Gene Detail
Summary
  • Symbol
    Alkbh5
  • Name
    alkB homolog 5, RNA demethylase
  • Synonyms
    Abh5, Ofoxd
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144489
    NCBI Gene: 268420
Location & Maps
more
  • Sequence Map
    Chr11:60536381-60558512 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22132 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.81 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ALKBH5, alkB homolog 5, RNA demethylase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ALKBH5, alkB homolog 5, RNA demethylase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ABH5, OFOXD, OFOXD1
  • Links
    NCBI Gene ID: 54890
    neXtProt AC: NX_Q6P6C2

  • Chr Location
    17p11.2; chr17:18183553-18209954 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9818
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: ALKBH5
  • Gene Tree
Human Diseases
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  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Alkbh5
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit reduced male fertility associated with oligo- and teratozoopermia and male germ cell apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007765 VEGA Gene Model | MGI Sequence Detail 22132 C57BL/6J ±  kb
transcript OTTMUST00000017734 VEGA | MGI Sequence Detail 5730 Not Applicable  
polypeptide OTTMUSP00000008172 VEGA | MGI Sequence Detail 395 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    82 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000003952 alkylated DNA repair protein alkB 5
  • EC
  • InterPro Domains
    IPR027450 Alpha-ketoglutarate-dependent dioxygenase AlkB-like
    IPR032860 RNA demethylase ALKBH5
Molecular
Reagents
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  • All nucleic 13
    Genomic 1
    cDNA 12

    Microarray probesets 7
Other
Accession IDs
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MGI:2144515
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Diseases 2
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:217675 Gao Z, et al., An AUTS2-Polycomb complex activates gene expression in the CNS. Nature. 2014 Dec 18;516(7531):349-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory