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Alkbh5 Gene Detail
Summary
  • Symbol
    Alkbh5
  • Name
    alkB homolog 5, RNA demethylase
  • Synonyms
    Abh5, Ofoxd
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144489
    NCBI Gene: 268420
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:60537683-60558512 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    76 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144489
protein coding gene Chr11:60536381-60558512 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018420
protein coding gene Chr11:60422550-60444570 (+)
A/J MGP_AJ_G0018389
protein coding gene Chr11:58126273-58148582 (+)
AKR/J MGP_AKRJ_G0018359
protein coding gene Chr11:60073497-60098505 (+)
BALB/cJ MGP_BALBcJ_G0018360
protein coding gene Chr11:58482533-58504840 (+)
C3H/HeJ MGP_C3HHeJ_G0018173
protein coding gene Chr11:59944077-59967214 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018812
protein coding gene Chr11:62331083-62353255 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016458
protein coding gene Chr11:55363585-55385008 (+)
CAST/EiJ MGP_CASTEiJ_G0017730
protein coding gene Chr11:60085379-60107287 (+)
CBA/J MGP_CBAJ_G0018147
protein coding gene Chr11:65067149-65089471 (+)
DBA/2J MGP_DBA2J_G0018256
protein coding gene Chr11:57781341-57803447 (+)
FVB/NJ MGP_FVBNJ_G0018247
protein coding gene Chr11:57462082-57483986 (+)
LP/J MGP_LPJ_G0018329
protein coding gene Chr11:61026349-61049164 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018271
protein coding gene Chr11:66114424-66136556 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018853
protein coding gene Chr11:60095940-60117832 (+)
PWK/PhJ MGP_PWKPhJ_G0017501
protein coding gene Chr11:58391323-58414076 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017293
protein coding gene Chr11:59895591-59917673 (+)
WSB/EiJ MGP_WSBEiJ_G0017781
protein coding gene Chr11:59778913-59802870 (+)



Homology
more
  • Human Ortholog
    ALKBH5, alkB homolog 5, RNA demethylase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ALKBH5, alkB homolog 5, RNA demethylase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ABH5, OFOXD, OFOXD1
  • Links
    NCBI Gene ID: 54890
    neXtProt AC: NX_Q6P6C2
    UniProt: Q6P6C2

  • Chr Location
    17p11.2; chr17:18183553-18209954 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9818
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ALKBH5
  • Gene Tree
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced male fertility associated with oligo- and teratozoopermia and male germ cell apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 268420 NCBI Gene Model | MGI Sequence Detail 20830 C57BL/6J ±  kb
transcript NM_172943 RefSeq | MGI Sequence Detail 6025 Not Specified  
polypeptide Q3TSG4 UniProt | EBI | MGI Sequence Detail 395 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    Genomic 1
    cDNA 13

    Microarray probesets 7
Other
Accession IDs
less
MGI:2144515
References
more
  • Summaries
    All 42
    Developmental Gene Expression 1
    Diseases 2
    Gene Ontology 7
    Phenotypes 16
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:258382 Tang C, et al., ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells. Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E325-E333

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/27/2018
MGI 6.13
The Jackson Laboratory