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Ppp4r3b Gene Detail
Summary
  • Symbol
    Ppp4r3b
  • Name
    protein phosphatase 4 regulatory subunit 3B
  • Synonyms
    mKIAA1387, Smek2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144474
    NCBI Gene: 104570
  • Gene Overview
    MyGene.info: PPP4R3B
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:29172890-29220797 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 16.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    272 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144474
protein coding gene Chr11:29172590-29220797 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018104
protein coding gene Chr11:27165612-27218156 (+)
A/J MGP_AJ_G0018076
protein coding gene Chr11:26177028-26226095 (+)
AKR/J MGP_AKRJ_G0018041
protein coding gene Chr11:27025367-27075174 (+)
BALB/cJ MGP_BALBcJ_G0018044
protein coding gene Chr11:26365325-26417341 (+)
C3H/HeJ MGP_C3HHeJ_G0017858
protein coding gene Chr11:26935802-26983724 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018497
protein coding gene Chr11:28136697-28184752 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016154
protein coding gene Chr11:24823024-24870238 (+)
CAST/EiJ MGP_CASTEiJ_G0017420
protein coding gene Chr11:26975171-27032605 (+)
CBA/J MGP_CBAJ_G0017832
protein coding gene Chr11:29427250-29487201 (+)
DBA/2J MGP_DBA2J_G0017942
protein coding gene Chr11:26030020-26080252 (+)
FVB/NJ MGP_FVBNJ_G0017934
protein coding gene Chr11:25833732-25882200 (+)
LP/J MGP_LPJ_G0018014
protein coding gene Chr11:27418944-27470154 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017960
protein coding gene Chr11:30491690-30547958 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018537
protein coding gene Chr11:27131422-27183007 (+)
PWK/PhJ MGP_PWKPhJ_G0017202
protein coding gene Chr11:26123533-26173302 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016997
protein coding gene Chr11:26810506-26860521 (+)
WSB/EiJ MGP_WSBEiJ_G0017473
protein coding gene Chr11:26820606-26872689 (+)



Homology
more
  • Human Ortholog
    PPP4R3B, protein phosphatase 4 regulatory subunit 3B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPP4R3B, protein phosphatase 4 regulatory subunit 3B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FLFL2, PP4R3B, PSY2, SMEK2, smk1
  • Links
    NCBI Gene ID: 57223
    neXtProt AC: NX_Q5MIZ7
    UniProt: Q5MIZ7

  • Chr Location
    2p16.1; chr2:55547292-55617757 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020463 Ensembl Gene Model | MGI Sequence Detail 47908 C57BL/6J ±  kb
transcript ENSMUST00000020755 Ensembl | MGI Sequence Detail 5125 Not Applicable  
polypeptide ENSMUSP00000020755 Ensembl | MGI Sequence Detail 820 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    Genomic 2
    cDNA 25

    Microarray probesets 8
Other
Accession IDs
less
MGI:2144578
References
more
  • Summaries
    All 40
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:256509 Chang WH, et al., Smek1/2 is a nuclear chaperone and cofactor for cleaved Wnt receptor Ryk, regulating cortical neurogenesis. Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10717-E10725

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory