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Arhgap44 Gene Detail
Summary
  • Symbol
    Arhgap44
  • Name
    Rho GTPase activating protein 44
  • Synonyms
    AU040829
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144423
    NCBI Gene: 216831
  • Gene Overview
    MyGene.info: ARHGAP44
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:65002039-65162961 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 40.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1539 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144423
protein coding gene Chr11:65002039-65163124 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018474
protein coding gene Chr11:65189266-65359666 (-)
A/J MGP_AJ_G0018443
protein coding gene Chr11:62759394-62925136 (-)
AKR/J MGP_AKRJ_G0018412
protein coding gene Chr11:64663900-64825343 (-)
BALB/cJ MGP_BALBcJ_G0018414
protein coding gene Chr11:63016786-63184157 (-)
C3H/HeJ MGP_C3HHeJ_G0018227
protein coding gene Chr11:64635329-64812805 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018866
protein coding gene Chr11:67171397-67337311 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016510
protein coding gene Chr11:59776308-59947437 (-)
CAST/EiJ MGP_CASTEiJ_G0017783
protein coding gene Chr11:64859169-65023452 (-)
CBA/J MGP_CBAJ_G0018201
protein coding gene Chr11:70128255-70309746 (-)
DBA/2J MGP_DBA2J_G0018310
protein coding gene Chr11:62305453-62467595 (-)
FVB/NJ MGP_FVBNJ_G0018300
protein coding gene Chr11:61960382-62122478 (-)
LP/J MGP_LPJ_G0018382
protein coding gene Chr11:65729572-65892192 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018324
protein coding gene Chr11:71015826-71189025 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018907
protein coding gene Chr11:64864141-65037331 (-)
PWK/PhJ MGP_PWKPhJ_G0017557
protein coding gene Chr11:62932312-63098074 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017347
protein coding gene Chr11:64705664-64886132 (-)
WSB/EiJ MGP_WSBEiJ_G0017836
protein coding gene Chr11:64477650-64641356 (-)



Homology
more
  • Human Ortholog
    ARHGAP44, Rho GTPase activating protein 44
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARHGAP44, Rho GTPase activating protein 44
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NPC-A-10, RICH2
  • Links
    NCBI Gene ID: 9912
    neXtProt AC: NX_Q17R89
    UniProt: Q17R89

  • Chr Location
    17p12; chr17:12789512-12991644 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased brain weight, abnormal dendritic spine morphology, hypoactivity, increased self-grooming behavior, abnormal response to novel objects, and impaired motor learning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033389 Ensembl Gene Model | MGI Sequence Detail 160923 C57BL/6J ±  kb
    transcript ENSMUST00000093002 Ensembl | MGI Sequence Detail 3982 Not Applicable  
    polypeptide ENSMUSP00000090681 Ensembl | MGI Sequence Detail 814 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144278, MGI:2144545
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:250218 Sarowar T, et al., Object Phobia and Altered RhoA Signaling in Amygdala of Mice Lacking RICH2. Front Mol Neurosci. 2017;10:180

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory