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Inca1
Gene Detail
Symbol

Name
ID
Inca1
inhibitor of CDK, cyclin A1 interacting protein 1
MGI:2144284
Feature Type
protein coding gene
Genetic Map
Chromosome 11
43.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:70688361-70700155 bp, - strand
From VEGA annotation of GRCm38

  11795 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:19481  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

HCOP human homology predictions: INCA1
Gene Tree: Inca1

Human
homologs
INCA1, inhibitor of CDK, cyclin A1 interacting protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 388324
neXtProt AC: NX_Q0VD86

Human Synonyms: HSD45

Human Chr (Location): 17p13.2; chr17:4988130-4997922 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Genomic Mutations involving Inca1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased cell proliferation in mouse embryonic fibroblasts and older mice exhibit abnormal spleen architecture, particularly in the white pulp, and extramedullary hematopoiesis.
 
Phenotype Images(1)
Interactions
Inca1 interacts with 46 markers (Mir1a-1, Mir1a-2, Mir24-1, ...)
Expression
Literature Summary: (1 records)
Data Summary: Results (18)    Tissues (18)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 18
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(18)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000006067 (Evidence)
Ensembl Gene Model ENSMUSG00000057054 (Evidence)
Entrez Gene 103844 (Evidence)
UniGene 101581
DFCI TC1585085, TC1596220
NIA Mouse Gene Index U084941
Consensus CDS Project CCDS24964.1, CCDS56789.1
International Mouse Phenotyping Consortium Status Inca1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006067 VEGA Gene Model | MGI Sequence Detail 11795 C57BL/6J ±  kb
transcript OTTMUST00000013676 VEGA | MGI Sequence Detail 1080 Not Applicable 
polypeptide OTTMUSP00000006338 VEGA | MGI Sequence Detail 231 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(30) UniProt(1)
Polymorphisms
SNPs within 2kb(112 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026238 Inhibitor of CDK interacting with cyclin A1
Protein Ontology PR:000009028 protein INCA1
References
(Earliest) J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
(Latest) J:175810 Zhang F, et al., The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects. PLoS One. 2011;6(7):e21505
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory