About   Help   FAQ
Inca1
Gene Detail
 Symbol
Name
ID
Inca1
inhibitor of CDK, cyclin A1 interacting protein 1
MGI:2144284
Feature Type protein coding gene
Genetic Map
Chromosome 11
43.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:70688361-70700155 bp, - strand
From VEGA annotation of GRCm38

  11795 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:19481  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Gene Tree: Inca1

Human
homologs
Human Homolog INCA1, inhibitor of CDK, cyclin A1 interacting protein 1
NCBI Gene ID 388324
neXtProt AC  NX_Q0VD86
Human Chr (Location)  17p13.2; chr17:4988130-4997919 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased cell proliferation in mouse embryonic fibroblasts and older mice exhibit abnormal spleen architecture, particularly in the white pulp, and extramedullary hematopoiesis.
 
Phenotype Images(1)
Interactions
Inca1 interacts with 46 markers (Mir1a-1, Mir1a-2, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process negative regulation of cell proliferation, negative regulation of cyclin-dependent protein serine/threonine kinase activity, ...
Component cytoplasm, nucleus
Function cyclin binding, cyclin-dependent protein serine/threonine kinase inhibitor activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (18)    Tissues (18)    Images (4)
Theiler Stages: 21
Assay TypeResults
RNA in situ 18
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(18)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006067 (Evidence)
Ensembl Gene ModelENSMUSG00000057054 (Evidence)
Entrez Gene103844 (Evidence)
UniGene101581
DFCITC1585085, TC1596220
NIA Mouse Gene IndexU084941
Consensus CDS ProjectCCDS24964.1, CCDS56789.1
International Mouse Knockout Project StatusInca1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006067 VEGA Gene Model | MGI Sequence Detail 11795 C57BL/6J ±  kb
transcript OTTMUST00000013676 VEGA | MGI Sequence Detail 1080 Not Applicable 
polypeptide OTTMUSP00000006338 VEGA | MGI Sequence Detail 231 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(34) UniProt(1)
Polymorphisms SNPs within 2kb(112 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026238 Inhibitor of CDK interacting with cyclin A1
Protein Ontology PR:000009028 protein INCA1
References (Earliest) J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
(Latest) J:175810 Zhang F, et al., The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects. PLoS One. 2011;6(7):e21505
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory