About   Help   FAQ
Tbc1d10a Gene Detail
Summary
  • Symbol
    Tbc1d10a
  • Name
    TBC1 domain family, member 10a
  • Synonyms
    EPI64, Tbc1d10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144164
    NCBI Gene: 103724
  • Gene Overview
    MyGene.info: TBC1D10A
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:4186833-4215507 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 2.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144164
protein coding gene Chr11:4186789-4215507 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017978
protein coding gene Chr11:1119680-1148087 (+)
A/J MGP_AJ_G0017951
protein coding gene Chr11:1129841-1160099 (+)
AKR/J MGP_AKRJ_G0017915
protein coding gene Chr11:1185418-1213932 (+)
BALB/cJ MGP_BALBcJ_G0017919
protein coding gene Chr11:1098838-1129466 (+)
C3H/HeJ MGP_C3HHeJ_G0017732
protein coding gene Chr11:1080892-1111828 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018372
protein coding gene Chr11:1199563-1228069 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016030
protein coding gene Chr11:1010237-1039042 (+)
CAST/EiJ MGP_CASTEiJ_G0017294
protein coding gene Chr11:1045002-1073540 (+)
CBA/J MGP_CBAJ_G0017707
protein coding gene Chr11:1445343-1477172 (+)
DBA/2J MGP_DBA2J_G0017818
protein coding gene Chr11:1035289-1064030 (+)
FVB/NJ MGP_FVBNJ_G0017809
protein coding gene Chr11:1067573-1096280 (+)
LP/J MGP_LPJ_G0017888
protein coding gene Chr11:1224108-1253779 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017835
protein coding gene Chr11:1113280-1142586 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018411
protein coding gene Chr11:1193076-1221812 (+)
PWK/PhJ MGP_PWKPhJ_G0017075
protein coding gene Chr11:1037507-1066106 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016871
protein coding gene Chr11:1149648-1184366 (+)
WSB/EiJ MGP_WSBEiJ_G0017348
protein coding gene Chr11:1057456-1086194 (+)



Homology
more
  • Human Ortholog
    TBC1D10A, TBC1 domain family member 10A
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TBC1D10A, TBC1 domain family member 10A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ130H16.1, dJ130H16.2, EPI64, TBC1D10
  • Links
    NCBI Gene ID: 83874
    neXtProt AC: NX_Q9BXI6
    UniProt: Q9BXI6

  • Chr Location
    22q12.2; chr22:30291990-30326966 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased circulating LDL cholesterol levels, decreased circulating alanine transaminase and alkaline phosphatase levels, abnormal liver physiology, and increased chromosomal stability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 103724 NCBI Gene Model | MGI Sequence Detail 28675 C57BL/6J ±  kb
    transcript NM_134023 RefSeq | MGI Sequence Detail 1929 FVB/N  
    polypeptide P58802 UniProt | EBI | MGI Sequence Detail 500 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR000195 Rab-GTPase-TBC domain
      IPR035969 Rab-GTPase-TBC domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 48
      cDNA 48

      Microarray probesets 3
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:225710 Tuck E, et al., A gene expression resource generated by genome-wide lacZ profiling in the mouse. Dis Model Mech. 2015 Nov 1;8(11):1467-78

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory