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Pnpo Gene Detail
Summary
  • Symbol
    Pnpo
  • Name
    pyridoxine 5'-phosphate oxidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144151
    NCBI Gene: 103711
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:96828651-96834812 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 60.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144151
protein coding gene Chr11:96828642-96834845 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019017
protein coding gene Chr11:99309827-99317349 (-)
A/J MGP_AJ_G0018985
protein coding gene Chr11:95237574-95247121 (-)
AKR/J MGP_AKRJ_G0018955
protein coding gene Chr11:98188563-98194608 (-)
BALB/cJ MGP_BALBcJ_G0018958
protein coding gene Chr11:95731700-95738013 (-)
C3H/HeJ MGP_C3HHeJ_G0018772
protein coding gene Chr11:98311768-98317806 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019410
protein coding gene Chr11:102392563-102400375 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017041
protein coding gene Chr11:92708457-92714640 (-)
CAST/EiJ MGP_CASTEiJ_G0018325
protein coding gene Chr11:99159659-99165745 (-)
CBA/J MGP_CBAJ_G0018743
protein coding gene Chr11:106581080-106589865 (-)
DBA/2J MGP_DBA2J_G0018851
protein coding gene Chr11:94795956-94801999 (-)
FVB/NJ MGP_FVBNJ_G0018840
protein coding gene Chr11:94273375-94279631 (-)
LP/J MGP_LPJ_G0018921
protein coding gene Chr11:99829931-99837796 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018867
protein coding gene Chr11:106524106-106530886 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019450
protein coding gene Chr11:98487517-98493558 (-)
PWK/PhJ MGP_PWKPhJ_G0018097
protein coding gene Chr11:95765968-95772084 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017887
protein coding gene Chr11:98218086-98224081 (-)
WSB/EiJ MGP_WSBEiJ_G0018375
protein coding gene Chr11:98396813-98405572 (-)



Homology
more
  • Human Ortholog
    PNPO, pyridoxamine 5'-phosphate oxidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PNPO, pyridoxamine 5'-phosphate oxidase
  • Synonyms
    HEL-S-302, PDXPO
  • Links
    NCBI Gene ID: 55163
    neXtProt AC: NX_Q9NVS9
    UniProt: Q9NVS9

  • Chr Location
    17q21.32; chr17:47941506-47949308 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human PNPO associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000018659 Ensembl Gene Model | MGI Sequence Detail 6162 C57BL/6J ±  kb
transcript ENSMUST00000018803 Ensembl | MGI Sequence Detail 1994 Not Applicable  
polypeptide ENSMUSP00000018803 Ensembl | MGI Sequence Detail 261 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 135
    cDNA 134
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:336444 Ngo EO, et al., Absence of pyridoxine-5'-phosphate oxidase (PNPO) activity in neoplastic cells: isolation, characterization, and expression of PNPO cDNA. Biochemistry. 1998 May 26;37(21):7741-8
  • Latest
    J:283699 Chen CC, et al., Vitamin B6 Addiction in Acute Myeloid Leukemia. Cancer Cell. 2020 Jan 13;37(1):71-84.e7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory