About   Help   FAQ
Pnpo Gene Detail
Summary
  • Symbol
    Pnpo
  • Name
    pyridoxine 5'-phosphate oxidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144151
    NCBI Gene: 103711
  • Gene Overview
    MyGene.info: PNPO
Location & Maps
more
  • Sequence Map
    Chr11:96937825-96943986 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6162 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 60.17 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PNPO, pyridoxamine 5'-phosphate oxidase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PNPO, pyridoxamine 5'-phosphate oxidase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HEL-S-302, PDXPO
  • Links
    NCBI Gene ID: 55163
    neXtProt AC: NX_Q9NVS9

  • Chr Location
    17q21.32; chr17:47941523-47949308 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PNPO associations

Human Disease Mouse Models
       Pyridoxamine 5-Prime-Phosphate Oxidase Deficiency; PNPOD   OMIM: 610090
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    3
  • Targeted
    3
  • Genomic Mutations
    1 involving Pnpo
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001731 VEGA Gene Model | MGI Sequence Detail 6162 C57BL/6J ±  kb
transcript OTTMUST00000003434 VEGA | MGI Sequence Detail 1994 Not Applicable  
polypeptide OTTMUSP00000001651 VEGA | MGI Sequence Detail 261 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    99 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012949 pyridoxine-5'-phosphate oxidase
  • EC
  • InterPro Domains
    IPR012349 FMN-binding split barrel
    IPR000659 Pyridoxamine 5'-phosphate oxidase
    IPR019740 Pyridoxamine 5'-phosphate oxidase, conserved site
    IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain
    IPR019576 Pyridoxine 5'-phosphate oxidase, dimerisation, C-terminal
Molecular
Reagents
less
  • All nucleic 134
    cDNA 133
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory