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Pnpo
Gene Detail
Symbol

Name
ID
Pnpo
pyridoxine 5'-phosphate oxidase
MGI:2144151
Feature Type
protein coding gene
Genetic Map
Chromosome 11
60.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:96937825-96943986 bp, - strand
From VEGA annotation of GRCm38

  6162 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5364  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PNPO
Protein SuperFamily: pyridoxamine-phosphate oxidase
Gene Tree: Pnpo

Human
homologs
PNPO, pyridoxamine 5'-phosphate oxidase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 55163
neXtProt AC: NX_Q9NVS9

Human Synonyms: HEL-S-302, PDXPO

Human Chr (Location): 17q21.32; chr17:47941523-47949308 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PNPO

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Genomic Mutations involving Pnpo (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pnpo interacts with 144 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process activation of mitophagy in response to mitochondrial depolarization, oxidation-reduction process, ...
Component cytoplasm, extracellular exosome, ...
Function FMN binding, oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (163)    Tissues (96)    Images (64)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 163
cDNA source data(131)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pnpo ; ZFIN pnpo    NEW 
Molecular
reagents
All nucleic(134) cDNA(133) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000001731 (Evidence)
Ensembl Gene Model ENSMUSG00000018659 (Evidence)
Entrez Gene 103711 (Evidence)
UniGene 254704
DFCI TC1571923
DoTS DT.101392822, DT.535998, DT.94253502
EC 1.4.3.5
Consensus CDS Project CCDS25308.1
International Mouse Phenotyping Consortium Status Pnpo
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001731 VEGA Gene Model | MGI Sequence Detail 6162 C57BL/6J ±  kb
transcript OTTMUST00000003434 VEGA | MGI Sequence Detail 1994 Not Applicable 
polypeptide OTTMUSP00000001651 VEGA | MGI Sequence Detail 261 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(99 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012349 FMN-binding split barrel
InterPro IPR000659 Pyridoxamine 5'-phosphate oxidase
InterPro IPR019740 Pyridoxamine 5'-phosphate oxidase, conserved site
InterPro IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain
InterPro IPR019576 Pyridoxine 5'-phosphate oxidase, dimerisation, C-terminal
Protein Ontology PR:000012949 pyridoxine-5'-phosphate oxidase
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory