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Psme4
Gene Detail
Symbol

Name
ID
Psme4
proteasome (prosome, macropain) activator subunit 4
MGI:2143994
Feature Type
protein coding gene
Genetic Map
Chromosome 11
18.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:30771726-30880361 bp, + strand
From VEGA annotation of GRCm38

  108636 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:113742  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

Gene Tree: Psme4

Human
homologs
Human Homolog PSME4, proteasome (prosome, macropain) activator subunit 4
NCBI Gene ID 23198
neXtProt AC  NX_Q14997
Human Synonyms  PA200
Human Chr (Location)  2p16.2; chr2:53864067-53970840 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(24) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show normal repair of DNA double-strand breaks but exhibit significantly reduced male fertility due to defects in spermatogenesis observed in both meiotic spermatocytes and postmeiotic haploid spermatids.
 
Interactions
Psme4 interacts with 253 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell differentiation, cellular response to DNA damage stimulus, ...
Component cytoplasm, cytosol, ...
Function lysine-acetylated histone binding, peptidase activator activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (82)    Tissues (10)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 82
cDNA source data(417)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(418) cDNA(417) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000005356 (Evidence)
Ensembl Gene ModelENSMUSG00000040850 (Evidence)
Entrez Gene103554 (Evidence)
UniGene240066
DFCITC1612003, TC1610141, TC1705552, TC1572585, TC1599099
DoTSDT.94190913, DT.493589, DT.101711171, DT.91314972, DT.101304750, DT.101140765, DT.94267371, DT.99843104
NIA Mouse Gene IndexU043153
Consensus CDS ProjectCCDS36124.1
International Mouse Knockout Project StatusPsme4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005356 VEGA Gene Model | MGI Sequence Detail 108636 C57BL/6J ±  kb
transcript OTTMUST00000011943 VEGA | MGI Sequence Detail 6491 Not Applicable 
polypeptide OTTMUSP00000005527 VEGA | MGI Sequence Detail 1843 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(769 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR021843 Protein of unknown function DUF3437
Protein Ontology PR:000013395 proteasome activator complex subunit 4
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:197675 Qian MX, et al., Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis. Cell. 2013 May 23;153(5):1012-24
All references(33)
Other
accession IDs
MGI:2144428

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory