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Psme4 Gene Detail
Summary
  • Symbol
    Psme4
  • Name
    proteasome (prosome, macropain) activator subunit 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143994
    NCBI Gene: 103554
  • Gene Overview
    MyGene.info: PSME4
Location & Maps
more
  • Sequence Map
    Chr11:30771726-30880361 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      108636 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 18.16 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PSME4, proteasome activator subunit 4
  • Vertebrate Orthologs
    12
  • Human Ortholog
    PSME4, proteasome activator subunit 4
    Orthology source: HomoloGene
  • Synonyms
    PA200
  • Links
    NCBI Gene ID: 23198
    neXtProt AC: NX_Q14997

  • Chr Location
    2p16.2; chr2:53864067-53970840 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 113742
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;3 zebrafish
  • HCOP
    human homology predictions: PSME4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Chemically induced (other)
    1
  • Gene trapped
    24
  • Targeted
    2
  • Genomic Mutations
    1 involving Psme4
  • Incidental Mutations
Mice homozygous for a knock-out allele show normal repair of DNA double-strand breaks but exhibit significantly reduced male fertility due to defects in spermatogenesis observed in both meiotic spermatocytes and postmeiotic haploid spermatids.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005356 VEGA Gene Model | MGI Sequence Detail 108636 C57BL/6J ±  kb
transcript OTTMUST00000011943 VEGA | MGI Sequence Detail 6491 Not Applicable  
polypeptide OTTMUSP00000005527 VEGA | MGI Sequence Detail 1843 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    765 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013395 proteasome activator complex subunit 4
  • InterPro Domains
    IPR011989 Armadillo-like helical
    IPR016024 Armadillo-type fold
    IPR032430 Proteasome activator Blm10, mid region
    IPR021843 Protein of unknown function DUF3437
Molecular
Reagents
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  • All nucleic 418
    cDNA 417
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGI:2144428
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:197675 Qian MX, et al., Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis. Cell. 2013 May 23;153(5):1012-24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory