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Psme4
Gene Detail
Symbol

Name
ID
Psme4
proteasome (prosome, macropain) activator subunit 4
MGI:2143994
Feature Type
protein coding gene
Genetic Map
Chromosome 11
18.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:30771726-30880361 bp, + strand
From VEGA annotation of GRCm38

  108636 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:113742  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

HCOP human homology predictions: PSME4
Gene Tree: Psme4

Human
homologs
PSME4, proteasome (prosome, macropain) activator subunit 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23198
neXtProt AC: NX_Q14997

Human Synonyms: PA200

Human Chr (Location): 2p16.2; chr2:53864067-53970840 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(24) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele show normal repair of DNA double-strand breaks but exhibit significantly reduced male fertility due to defects in spermatogenesis observed in both meiotic spermatocytes and postmeiotic haploid spermatids.
 
Interactions
Psme4 interacts with 253 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell differentiation, cellular response to DNA damage stimulus, ...
Component cytoplasm, cytosol, ...
Function lysine-acetylated histone binding, peptidase activator activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (82)    Tissues (10)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 82
cDNA source data(417)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase psme4    NEW 
Molecular
reagents
All nucleic(418) cDNA(417) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000005356 (Evidence)
Ensembl Gene Model ENSMUSG00000040850 (Evidence)
Entrez Gene 103554 (Evidence)
UniGene 240066
DFCI TC1599099, TC1612003, TC1610141, TC1705552, TC1572585
DoTS DT.101140765, DT.99843104, DT.101304750, DT.101711171, DT.94267371, DT.493589, DT.91314972, DT.94190913
NIA Mouse Gene Index U043153
Consensus CDS Project CCDS36124.1
International Mouse Phenotyping Consortium Status Psme4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005356 VEGA Gene Model | MGI Sequence Detail 108636 C57BL/6J ±  kb
transcript OTTMUST00000011943 VEGA | MGI Sequence Detail 6491 Not Applicable 
polypeptide OTTMUSP00000005527 VEGA | MGI Sequence Detail 1843 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(769 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR021843 Protein of unknown function DUF3437
Protein Ontology PR:000013395 proteasome activator complex subunit 4
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:197675 Qian MX, et al., Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis. Cell. 2013 May 23;153(5):1012-24
All references(31)
Other
accession IDs
MGI:2144428

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory